Why Tumors that Return Are So Tough (1 of 3) (image) American Association for the Advancement of Science Share Print E-Mail Caption Metabolic images from a patient who had an original diagnosis of low-grade astrocytoma that transformed to a high-grade glioma (GBM) at recurrence are shown. The image shows that tissue within the same tumor mass can be low-grade (blue/green) or high-grade (yellow/red), and these regions may have different types of genetic mutations. This image relates to a paper that appeared in the 12 Dec., 2013, issue of Science Express, published by AAAS. The paper, by Brett E. Johnson at the University of California, San Francisco in San Francisco, CA, and colleagues was titled, "Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma." Credit [Image courtesy of Sarah J. Nelson] Usage Restrictions Please cite the owner of the image when publishing. This image may be freely used by reporters as part of news coverage, with proper attribution. Non-reporters must contact Science for permission. Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.