Contact: Jeff Falk
Caption: Rice University scientists engineered a synthetic genetic clock inside a mutant Escherichia coli bacteria that keeps time despite rising or falling temperature. In an experiment, the researchers isolated a small number of engineered bacteria under a fluorescent microscope and captured images over three hours as a single cell (yellow arrow) oscillated at a regular clip between states despite changing conditions. They found altering one amino acid to make a regulator protein sensitive to temperature provided the right feedback to the bacteria's circadian clock.
Credit: Bennett Lab/Rice University
Usage Restrictions: None
Related news release: Synthetic genetic clock checks the thermometer