Brain Model (image) Radiological Society of North America Caption Medial, inferior, superior, and lateral images of a three-dimensional FreeSurfer reference brain model show regions of accelerated atrophy in the presence of APOE epsilon 4 in subjects with MCI. Effect size of the APOE epsilon 4 acceleration of cortical atrophy is depicted by color: Blue signifies a magnitude of Cohen d value of less than 0.25; yellow, 0.25.35; and red, more than 0.35. Gray areas were not examined. Credit Radiological Society of North America Usage Restrictions May use with proper credit Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.