Medial, inferior, superior, and lateral images of a three-dimensional FreeSurfer reference brain model show regions of accelerated atrophy in the presence of APOE epsilon 4 in
subjects with MCI. Effect size of the APOE epsilon 4 acceleration of cortical atrophy is depicted by
color: Blue signifies a magnitude of Cohen d value of less than 0.25; yellow, 0.25.35; and
red, more than 0.35. Gray areas were not examined.