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Contact: Nick Zagorski
American Society for Biochemistry and Molecular Biology

Model of Self-Renewal Signaling in Mouse ES Cells

Caption: Model displayes external factors that act to block stem cells from differentiating into different types of adult tissue. LIF activates STAT3 and blocks non-neural differentiation by induction of Myc, while BMP/Smad signaling through HS chains blocks neural differentiation by induction of Id. Wnt/b-catenin signaling through HS chains blocks primitive endodermal differentiation by induction of Nanog. FGF may contribute to proliferation through HS chains. HS chain dependent signaling by unknown factors may regulate proliferation and Oct3/4 expression.

Credit: Shoko Nishihara

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Related news release: Story ideas from the Journal of Biological Chemistry

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