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Keys to Persistent Survival

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Caption: This video shows live imaging microscopy of Salmonella exposed to the antibiotic cefotaxime within host-infected macrophage. Bacteria remaining after exposure to cefotaxime were only non-replicating bacteria (red), while replicating bacteria (green) were lysed. This video relates to a paper that appeared in the 10 Jan., 2014, issue of Science, published by AAAS. The paper, by Sophie Helaine at the Medical Research Council Centre for Molecular Bacteriology and Infection in London, UK, and colleagues was titled, "Internalization of Salmonella by Macrophages Induces Formation of Nonreplicating Persisters."

Credit: [Video courtesy of Sophie Helaine]

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