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Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Alpha-synuclein Forms Lewy Body-like Inclusions

Caption: Alpha-synuclein forms Lewy Body-like inclusions in the cytoplasm of yeast (left), but these are dissolved and alpha-synuclein returns to the plasma membrane upon expression of an engineered Hsp104 variant.

Credit: James Shorter, Ph.D., Perelman School of Medicine, University of Pennsylvania; Cell

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Related news release: Unraveling misfolded molecules using 'reprogrammed' yeast protein


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