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Contact: Karin Eskenazi
ket2116@columbia.edu
212-342-0508
Columbia University Medical Center

Common Blood Cancer May Be Initiated by Single Mutation in Bone

Caption: Mutated beta-catenin in bone cells may cause up to 40 percent of acute myeloid leukemia cases. In the cells of healthy subjects (left), beta catenin proteins (red dots) sit along the outer edges of the cell. In approximately 40 percent of AML patients (right), abnormal beta-catenin proteins (red dots) move into the cell interior; in mouse models, this movement sets cancer-causing changes into motion.

Credit: Credit: Dr. Aruna Kode/Kousteni lab, Columbia University Medical Center.

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Related news release: Common blood cancer may be initiated by single mutation in bone cells


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