Key NMDA Binding Site in Action (image) Cold Spring Harbor Laboratory Caption Overactivation of NMDA receptors causes nerve-cell toxicity, implicated in several devastating neurological and psychiatric illnesses. A drug is sought to selectively block or antagonize NMDA receptors, while not affecting other types of glutamate receptors. Here, crystal structures obtained by the Furukawa lab reveal four ways in which compounds bind the receptor (from left to right, top, then bottom): L-glutamate (an activator of the receptor); and 3 drug-like compounds that to varying degrees block the receptor: DCKA; D-AP5; and PPDA. Credit Furukawa Lab, CSHL Usage Restrictions please give credit Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.