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Contact: Robert Sanders
University of California - Berkeley

Nef Binds to CD4 Receptor

Caption: The AIDS virus enters immune cells by binding to CD4 receptors embedded in the membrane (parallel lines) of the cell. But once a virus enters the cell, it makes a protein, Nef, that binds to the protein complex underlying CD4, tagging it for the waste bin. Potential anti-HIV drugs would disable one of the proteins (colored blobs) to which Nef binds, interfering with HIV's strategy for spreading through the body.

Credit: Image by James Hurley, UC Berkeley.

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