Cas9 and Guide RNA with DNA (image) DOE/Lawrence Berkeley National Laboratory Caption Upon binding with guide RNA, the two structural lobes of Cas9 reorient so that the two nucleic acid binding clefts face each other, forming a central DNA binding channel that interfaces with target DNA. Credit Image courtesy of Doudna, Nogales, et. al Usage Restrictions None Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.