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Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory

Cas9 and Guide RNA with DNA

Caption: Upon binding with guide RNA, the two structural lobes of Cas9 reorient so that the two nucleic acid binding clefts face each other, forming a central DNA binding channel that interfaces with target DNA.

Credit: Image courtesy of Doudna, Nogales, et. al

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