The Mug Shot of a Genome Editor (1 of 2) (video) American Association for the Advancement of Science Share Print E-Mail Loading video... Caption This video illustrates the common Cas9 functional core defined by structural comparison of SpyCas9 and AnaCas9. Surface representations of SpyCas9 (top) and AnaCas9 (bottom) with conserved RuvC, HNH, Arg-rich, Topo-homology and CTD domains, are colored as in Fig. 3F. The structurally preserved portion of the alpha-helical lobe is colored green. The non-conserved regions of each protein are colored in gray (see also Figure 3F). This video relates to a paper that appeared in the Feb. 6, 2014, issue of Science Express, published by AAAS. The paper, by Martin Jinek and at the University of Zurich in Zurich, Switzerland, and colleagues was titled, "Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation." Credit Video courtesy of Dr. Fuguo Jiang Usage Restrictions Please cite the owner of the video when publishing. This video may be freely used by reporters as part of news coverage, with proper attribution. Non-reporters must contact Science for permission. Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.