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Contact: Dr. Andreas Battenberg
Technische Universitaet Muenchen

Disruption of the Bacterial Protease ClpP

Caption: Some smaller molecules (such as the Lactone in the middle) are able to destruct the arrangement of the amino acids required for the cohesion of the subunits of the bacterial protease ClpP. As a result the protease breaks into two parts, which are completely inactive. This approach massively disturbs the metabolism of the bacterium, giving the immune system time to react. And, because the bacterium isn't killed, the development of new resistances can be avoided.

Credit: Malte Gersch / TU Muenchen

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