How Lamin-A Controls Cell Migration Via Nuclear Stiffness (image) University of Pennsylvania Share Print E-Mail Caption To migrate to other parts of the body, a cell's nucleus must squeeze through pores -- and survive the trip. Too much lamin-A in the nucleus and it will be too stiff to fit through pores; too little and it will break apart in the process, killing the cell. Knowing the optimal level of lamin-A for keeping cells in place could have applications in cancer treatment and stem cell therapies. Credit University of Pennsylvania, Journal of Cell Biology Usage Restrictions With credit. Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.