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Contact: Evan Lerner
University of Pennsylvania

How Lamin-A Controls Cell Migration Via Nuclear Stiffness

Caption: To migrate to other parts of the body, a cell's nucleus must squeeze through pores -- and survive the trip. Too much lamin-A in the nucleus and it will be too stiff to fit through pores; too little and it will break apart in the process, killing the cell. Knowing the optimal level of lamin-A for keeping cells in place could have applications in cancer treatment and stem cell therapies.

Credit: University of Pennsylvania, Journal of Cell Biology

Usage Restrictions: With credit.

Related news release: Penn researchers show nuclear stiffness keeps stem cells and cancer cells in place

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