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Contact: A'ndrea Elyse Messer
Penn State

Apert Mice

Caption: This image shows craniofacial growth patterns in mouse models for Apert syndrome. Apert syndrome is caused by two neighboring mutations on Fibroblast growth factor receptor 2 (FGFR2). Multimodal imaging and segmentation was used to visualize and quantitate overall morphology of soft tissues (gray), skull (yellow), inner ear (purple), nasopharynx (pink) and globe of the eye (green) in Fgfr2+/S252W Apert syndrome mice and Fgfr2+/P253R Apert syndrome mice at embryonic day 17.5 (E17.5) (left) and on the day of birth (P0) (right) (Fgfr2+/S252W mice are shown).

Credit: Joan Richtsmeier

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Related news release: 3-D imaging sheds light on Apert syndrome development

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