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Contact: Sathya Achia Abraham
Virginia Commonwealth University

Manganese Transport and Role in Providing Nucleotide Building Blocks for DNA

Caption: This image is an overview of manganese transport and role in providing nucleotide building blocks for DNA. The red, blue and brown shapes are components of the complex that transports manganese into the bacterial cell. NrdEF is the ribonucleotide reductase enzyme that creates the nucleotides and NrdI is the protein required for attaching manganese to the enzyme. Elimination of either NrdEF or NrdI completely prevented Streptococcus sanguinis from causing infective endocarditis.

Credit: Figure courtesy of Todd Kitten, Ph.D.,/ VCU.

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