JP2 Protein in Heart (image) University of Iowa Health Care Caption A University of Iowa study shows that changes in microtubule density directly affect where a critical protein called junctophilin-2 (JP2) is located within heart cells. If JP2 is not in its proper location, heart muscle can't function properly, which leads to the development and progression of heart failure. The green areas in the images show the orderly nature of JP2 protein's distribution in normal human heart muscle (left panel) compared to the disorganized localization of the protein in unhealthy heart muscle (center and right panel). Credit Long-Sheng Song, University of Iowa Usage Restrictions Please request permission to use image from email@example.com Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.