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Contact: Dan Ferber
Wyss Institute for Biologically Inspired Engineering at Harvard

Spotting DNA Cages with Blinking DNA

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Caption: To create supersharp images of their cage-shaped DNA polyhedral, the scientists used DNA-PAINT, a microscopy method that uses short strands of DNA (yellow) labeled with a fluorescent chemical (green) to bind and release partner strands on polyhedra corners, causing them to blink. The blinking corners reveal the shape of structures far too small to be seen with a conventional light microscope.

Credit: Harvard's Wyss Institute and Harvard Medical School

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