Mutations (image) Rice University Caption Co-evolved mutations in genetic sequences that code proteins show researchers how a protein is likely to fold and what forms it may take as it carries out its function. Scientists at Rice University used the technique called direct coupling analysis in combination with structure-based models to find a previously hidden conformation of a molecular motor responsible for degrading misfolded proteins in bacteria. Credit Faruck Morcos/Rice University Usage Restrictions None Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.