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Contact: David Ruth
david@rice.edu
713-348-6327
Rice University

Mutations

Caption: Co-evolved mutations in genetic sequences that code proteins show researchers how a protein is likely to fold and what forms it may take as it carries out its function. Scientists at Rice University used the technique called direct coupling analysis in combination with structure-based models to find a previously hidden conformation of a molecular motor responsible for degrading misfolded proteins in bacteria.

Credit: Faruck Morcos/Rice University

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