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Contact: Kristin Kessler
krk@stowers.org
816-489-3773
Stowers Institute for Medical Research

Could Far-Flung Mutations in the Genome Activate Cancer-Causing Genes? Ask an Expert!

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Caption: Stowers Institute investigator, Ali Shilatifard, Ph.D., will take center stage at a Meet-the-Expert Session at the 2014 Annual Meeting of the American Association for Cancer Research (AACR) being held April 5-9 in San Diego. The AACR meeting is the most important international forum for sharing breakthroughs in cancer research. This year's event could attract over 17,000 participants from 60 different countries.

Attendees of Meet-the-Expert sessions are briefed on a cutting-edge topic by an authority in the field and then the issue is discussed. Shilatifard's talk entitled, "Enhancer Malfunction in Cancer," will address how disturbances in the regions of the genome that flank (rather than contain) protein-coding genes might promote disease.

A Perspective published with his postdocs, Hans-Martin Herz, Ph.D. and Deqing Hu, Ph.D., in the March 20 issue of Molecular Cell, will serve as the basis for Shilatifard's AACR talk. In it, they summarize how aberrant enhancer activity -- due either to mutations in enhancer DNA or in genes that encode proteins that interact with enhancers -- may promote oncogenesis.

Credit: Stowers Institute for Medical Research

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Related news release: Could far-flung mutations in the genome activate cancer-causing genes? Ask an expert!


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