High-affinity Ligand Prevents Inappropriate Integrin Activation (image) Massachusetts General Hospital Caption Left: the two peptide chains of an integrin receptor, colored red and blue, extend through the cell membrane into the extracellular space. Center: when bound to the common form of the FN10 ligand or to a ligand-mimicking molecule, the integrin becomes activated, changing its shape and causing the cell to become sticky. Right: binding of the high-affinity form of FN10 does not cause the integrin to shape-shift, blocking its activation. Credit M. Amin Arnaout, MD, Massachusetts General Hospital Usage Restrictions None Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.