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Contact: Sue McGreevey
Massachusetts General Hospital

High-affinity Ligand Prevents Inappropriate Integrin Activation

Caption: Left: the two peptide chains of an integrin receptor, colored red and blue, extend through the cell membrane into the extracellular space. Center: when bound to the common form of the FN10 ligand or to a ligand-mimicking molecule, the integrin becomes activated, changing its shape and causing the cell to become sticky. Right: binding of the high-affinity form of FN10 does not cause the integrin to shape-shift, blocking its activation.

Credit: M. Amin Arnaout, MD, Massachusetts General Hospital

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