Contact: Juliette Savin
Caption: In order to estimate the effects of disulfiram or D-penicillamine pretreatment on urinary excretion of 64CuCl2, PET imaging studies were performed in MD model mice. Copper accumulation in the kidney of MD model mice was significantly lower in disulfiram or D-penicillamine-treated mice than in untreated mice (p<0.05). D-penicillamine in particular enhanced urinary copper excretion but decreased copper accumulation in most organs investigated.
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