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Contact: Chew Munkit
World Scientific

Captured Rotavirus Double-Layered Particles in the Midst of Producing RNA

Caption: The schematic represents an EM Affinity Grid (gray square) coated with adaptor molecules (red and dark blue) that anchor active rotavirus DLPs (yellow) to the Affi nity Grid. Cryo-Electron Microscopy (EM) image of actively transcribing DLPs reveals RNA strands (gray strands) emerging from the virus capsid. Three-dimensional image reconstructions of DLPs (light blue) that actively produce RNA reveal strong density within the viral core. Diameter of each reconstruction is ~80 nm.

Credit: Credit: Deborah F. Kelly, Virginia Tech Carilion Research Institute, Virginia Tech.

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