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Contact: Linda Huynh
linda.huynh@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases

CDG-IIb

Caption: Viruses (blue and pink) must use host cells (green) to create more viruses that spread infection (top panel). CDG-IIb patients have defective glycosylation, the process of adding sugars to proteins, resulting in poor production of viruses that depend on this process, such as HIV and influenza (bottom panel). The scientists also show that viruses coming from the patients' cells (orange) are less infectious because of changes to their outer shields.

Credit: NIAID

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