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Contact: Jules Asher
NIMHpress@nih.gov
301-443-4536
NIH/National Institute of Mental Health

Antidepressant Effects

Caption: Researchers produced antidepressant-like behavioral effects by reversing out-of-balance electrical activity in reward circuit neurons of susceptible mice exposed to social stress. Further increasing an excitatory current (lh potentiation) triggered a compensatory increase in a potassium channel current (K' current) -- as did activating the potassium channel (K+ current) using pulses of light in mice with brain circuitry genetically engineered to respond to it (optogenetic excessive activation).

Credit: Ming-Hu Han, Ph.D., Icahn School of Medicine at Mount Sinai

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