Antidepressant Effects (image) NIH/National Institute of Mental Health Caption Researchers produced antidepressant-like behavioral effects by reversing out-of-balance electrical activity in reward circuit neurons of susceptible mice exposed to social stress. Further increasing an excitatory current (lh potentiation) triggered a compensatory increase in a potassium channel current (K' current) -- as did activating the potassium channel (K+ current) using pulses of light in mice with brain circuitry genetically engineered to respond to it (optogenetic excessive activation). Credit Ming-Hu Han, Ph.D., Icahn School of Medicine at Mount Sinai Usage Restrictions None Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.