Contact: Jules Asher
NIH/National Institute of Mental Health
Caption: Researchers produced antidepressant-like behavioral effects by reversing out-of-balance electrical activity in reward circuit neurons of susceptible mice exposed to social stress. Further increasing an excitatory current (lh potentiation) triggered a compensatory increase in a potassium channel current (K' current) -- as did activating the potassium channel (K+ current) using pulses of light in mice with brain circuitry genetically engineered to respond to it (optogenetic excessive activation).
Credit: Ming-Hu Han, Ph.D., Icahn School of Medicine at Mount Sinai
Usage Restrictions: None
Related news release: Jump-starting natural resilience reverses stress susceptibility