Preventing Epilepsy after Severe Head Trauma (image) University of California - Berkeley Share Print E-Mail Caption When the blood-brain barrier is disrupted by a severe head injury, the blood protein albumin leaks into the brain and activates the TGF-beta receptor on astrocytes (tan cells), which triggers a cascade of events leading to inflammation. The net result can be hyperexcitable neurons (yellow) and epileptic seizures. Kaufer, Friedman and colleagues discovered this cause and effect and identified a drug that blocks the TGF-beta receptor, preventing seizures in rats. Credit Image by Greg Chin, Vlad Senatorov and Oscar Vasquez (UC Berkeley) Usage Restrictions None Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.