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Contact: Daniel Stolte
University of Arizona

Mismatch between Virus Antigens and Antibodies

Caption: Fatalities by birth year for H5N1 and H7N9: Most patients with birth years prior to 1968 are expected to have been initially exposed, as children, to a group 1 HA. The researchers found that most H5N1 vs. H7N9 mortality in these age groups is caused by the mismatched group 2 H7 HA virus. Conversely, most of those born in 1968 and later were exposed first to a group 2 HA (H3N2, orange shading). The mismatched H5 HA virus causes most mortality in these age groups.

Credit: Michael Worobey

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