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Contact: Jaclyn Jansen
Cold Spring Harbor Laboratory

Neuron Hyperactivation in the Brain Leads to Depression

Caption: Researchers at Cold Spring Harbor Laboratory have identified the neurons in the brain that determine if a mouse will learn to cope with stress or become depressed. These neurons, located in a region of the brain known as the medial prefrontal cortex (green, top image), become hyperactive in depressed mice (bottom panel is close-up of above, yellow indicates activation). The team showed that this enhanced activity in fact causes depression.

Credit: Bo Li/ Cold Spring Harbor Laboratory

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