Contact: Peter Tarr
Cold Spring Harbor Laboratory
Caption: The PTP1B inhibitor MSI-1436 (trodusquemine) binds at two sites on the enzyme. The principal allosteric site, a weaker alternate site, and the previously recognized main, or catalytic, binding site are shown in this rendering.
Credit: Tonks lab/Cold Spring Harbor Laboratory
Usage Restrictions: give credit please
Related news release: Team validates potentially powerful new way to treat HER2-positive breast cancer