Contact: Lynn Yarris
DOE/Lawrence Berkeley National Laboratory
Caption: GTP hydrolysis of tubulin protein releases a phosphate, causing compaction of the E-site and rearrangement of the α-tubulin monomer that generates a destabilizing strain on the structure. Taxol binding reverses the E-site compaction and α-tubulin rearrangement.
Credit: Image courtesy of Nogales Lab
Usage Restrictions: None
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