How Taxol Works (image) DOE/Lawrence Berkeley National Laboratory Caption GTP hydrolysis of tubulin protein releases a phosphate, causing compaction of the E-site and rearrangement of the α-tubulin monomer that generates a destabilizing strain on the structure. Taxol binding reverses the E-site compaction and α-tubulin rearrangement. Credit Image courtesy of Nogales Lab Usage Restrictions None Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.