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Contact: Lynn Yarris
DOE/Lawrence Berkeley National Laboratory

How Taxol Works

Caption: GTP hydrolysis of tubulin protein releases a phosphate, causing compaction of the E-site and rearrangement of the α-tubulin monomer that generates a destabilizing strain on the structure. Taxol binding reverses the E-site compaction and α-tubulin rearrangement.

Credit: Image courtesy of Nogales Lab

Usage Restrictions: None

Related news release: New details on microtubules and how the anti-cancer drug Taxol works

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