SET2 Diagram (image) University of North Carolina Health Care Caption The enzyme SET2 is needed for DNA repair, a critical step that keeps cells from mutating into cancer cells. When mutated, the human version of the enzyme--SETD2--has been implicated in kidney cancer. Credit Max Englund, UNC Health Care Usage Restrictions use with credit. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.