Contact: Caroline Perry
Caption: This diagram shows a cell encapsulated in an interpenetrating network of alginate (blue) and reconstituted basement membrane matrix (green). Integrin receptors on the cell membrane bind to ligands in the extracellular matrix. The alginate network stiffens the matrix without creating new biochemical bonds so that the researchers can study stiffness in isolation.
Credit: Image courtesy of Ovijit Chaudhuri, Harvard University.
Usage Restrictions: Editorial use only.
Related news release: Tugging on the 'malignant' switch