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Contact: Abby Robinson
abbyr@umd.edu
301-405-5845
University of Maryland

Human Gene's Protein Factory Has a Helpful Glitch

Caption: The human gene CCR5 is critical for HIV infection. A complex structure in its messenger RNA can cause the ribosome to slip at the area in green, making the ribosome read the remaining genetic code as nonsense RNA. This decreases the amount of CCR5 protein produced. A microRNA (miR-1224, in purple) increases stalling at that site. This causes more slippage, further reducing CCR5 production and helping to regulate the immune response.

Credit: Bruce A. Shapiro and Wojciech K. Kasprzak.

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Related news release: Human cells' protein factory has an alternate operating manual


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