Contact: Julia Evangelou Strait
Washington University School of Medicine
Caption: Mice missing two important proteins of the vascular system develop normally and appear healthy in adulthood, as long as they don't become injured. If they do, their wounds don't heal properly, a new study shows. The research, at Washington University School of Medicine in St. Louis, may have implications for treating diseases involving abnormal blood vessel growth, such as the impaired wound healing often seen in diabetes and the loss of vision caused by macular degeneration. The mouse retina responds to injury by growing new, leaky blood vessels. This abnormal response obscures vision. The new study suggests inhibiting FGF signaling in the eye may help prevent this process.
Credit: Rei Nakamura, PhD
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