Stemming a Tide of Wrinkles (image) University of Michigan Health System Caption Wrinkles form because the skin's collagen breaks down with age and sun exposure. Some treatments encourage new collagen to form. Left: Fibroblasts (collagen-making cells), shown in yellow, in aging skin. Center: After the injection of the wrinkle filler Restylane, the fibroblasts begin to stretch. Right: Stretched fibroblasts have created new collagen (in red). Credit Laura van Goor, University of Michigan Usage Restrictions None Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.