Researchers Pinpoint Gene Mutations Responsible for 10 Percent of Schizophrenia

Contact: Susan Craig
sc2756@columbia.edu
212-305-9746
Columbia University Medical Center

Researchers Pinpoint Gene Mutations Responsible for 10 Percent of Schizophrenia

Caption: A. Genetic mutations that result in fewer than two (middle offspring) or more than two (right offspring) genomic copies of a chromosomal region, are present in individuals who have schizophrenia, but not present in their biological parents who do not have the disease. For comparison, a family with an unaffected offspring is indicated at the left. B. A schematic representation of a spontaneous copy number mutation found in one individual with schizophrenia. This mutation results in loss of genes, including a gene affecting neurodevelopment (EPHB1).

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