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Contact: Michael Heller
mheller@aecom.yu.edu
718-430-4186
Albert Einstein College of Medicine
Caption: BBB breakdown: The slide at left, below, shows a brain section of a control (non-HIV-infected) mouse following exposure to LPS. Proteins (stained yellow) lining the BBB exhibit some breaks but are relatively uncompromised. Slide at right shows a brain section of a transgenic mouse (systemically infected with HIV) following exposure to LPS. Here the combination of HIV infection and LPS exposure has severely fragmented the proteins lining the BBB.
Credit: Albert Einstein College of Medicine
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