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Department of Health and Human Services

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Funded News


Key: Meeting M      Journal J      Funder F

Showing releases 1-25 out of 3756.

1 | 2 | 3 | 4 | 5 > >>

Public Release: 3-Sep-2015
PLOS ONE
Rapid testing for TB aims to reduce drug resistance, lower mortality rate
Researchers at University of California, San Diego School of Medicine have documented the accuracy of three new tests for more rapidly diagnosing drug-resistant forms of tuberculosis, which are much harder and more expensive to treat and which, experts say, represent a major threat to global public health.
NIH/National Institute of Allergy and Infectious Diseases

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 3-Sep-2015
PLOS Pathogens
Penn study identifies viral product that promotes immune defense against RSV
Research led by University of Pennsylvania's Carolina López found a viral product that promotes a strong immune response against respiratory syncytial virus, a threat to infants and the elderly.
NIH/National Institute of Allergy and Infectious Disease

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania

Public Release: 3-Sep-2015
Lancet Diabetes and Endocrinology
Increased odds for type 2 diabetes after prenatal exposure to Ukraine famine of 1932-33
Men and women exposed in early gestation to the man-made Ukrainian Famine of 1932-33 in regions with extreme food shortages were 1.5 times more likely to be diagnosed with Type 2 diabetes in adulthood. There was no diabetes increase among individuals born in regions with no famine. This is the first large-scale study of the relationship between famine severity during different stages of prenatal development and Type 2 diabetes risk.
Ukraine State Diabetes Mellitus program, National Institutes of Health

Contact: Stephanie Berger
sb2247@columbia.edu
212-305-4372
Columbia University's Mailman School of Public Health

Public Release: 3-Sep-2015
Scientists win up to $10 million to complete preclinical trials for new migraine treatment
Scientists at The Scripps Research Institute have received a grant of nearly $4.5 million -- with the possibility of up to $10 million including outsourced studies -- from the National Institute of Neurological Disorders and Stroke to complete preclinical studies on a new anti-migraine drug candidate.
NIH/National Institute of Neurological Disorders and Stroke

Contact: Madeline McCurry-Schmidt
madms@scripps.edu
858-784-9254
Scripps Research Institute

Public Release: 3-Sep-2015
Cell Metabolism
New strategy to lower blood sugar may help in diabetes treatment
Working in mice, researchers at Washington University School of Medicine in St. Louis showed they could reduce glucose production in the liver and lower blood sugar levels. They did so by shutting down a liver protein involved in making glucose, an approach that may help treat type 2 diabetes.
NIH/National Institute of Diabetes and Digestive and Kidney Diseases, NIH/National Institute on Alcohol Abuse and Alcoholism, The Foundation for Barnes-Jewish Hospital

Contact: Jim Dryden
jdryden@wustl.edu
314-286-0110
Washington University School of Medicine

Public Release: 3-Sep-2015
Cell Metabolism
Targeting glucose production in liver may lead to new diabetes therapies
A new University of Iowa study shows that a biological checkpoint known as the Mitochondrial Pyruvate Carrier is critical for controlling glucose production in the liver and could potentially be a new target for drugs to treat diabetes.
National Institutes of Health, Robert A. Welch Foundation, Edward Mallinckrodt Jr. Foundation, and American Diabetes Association

Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-356-7124
University of Iowa Health Care

Public Release: 3-Sep-2015
Journal of Clinical Oncology
Acupuncture reduces hot flashes in breast cancer survivors
Acupuncture may be a viable treatment for women experiencing hot flashes as a result of estrogen-targeting therapies to treat breast cancer, according to a new study. Hot flashes are particularly severe and frequent in breast cancer survivors, but current FDA-approved remedies for these unpleasant episodes, such as hormone replacement therapies are off-limits to breast cancer survivors because they include estrogen. The results of the study are published this week in the Journal of Clinical Oncology.
National Institutes of Health

Contact: Katie Delach
katie.delach@uphs.upenn.edu
215-349-5964
University of Pennsylvania School of Medicine

Public Release: 3-Sep-2015
Science
New role for an old protein: Cancer causer
A protein known to play a role in transporting the molecular contents of normal cells into and out of various intracellular compartments can also turn such cells cancerous by stimulating a key growth-control pathway.
National Institutes of Health, Starr Cancer Consortium Award, US Department of Defense

Contact: Matt Fearer
fearer@wi.mit.edu
617-452-4630
Whitehead Institute for Biomedical Research

Public Release: 3-Sep-2015
Nature Communications
Targeting newly discovered pathway sensitizes tumors to radiation and chemotherapy
In some patients, aggressive cancers can become resistant to chemotherapy and radiation treatments. In a paper published in the journal Nature Communications, University of California, San Diego School of Medicine researchers identified a pathway that causes the resistance and a new therapeutic drug that targets this pathway.
National Institutes of Health, California Breast Cancer Research Foundation IDEA Award and ACS IRG

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 3-Sep-2015
Maternal and Child Health Journal
Babies benefit from parenting classes even before birth
A brief series of classes to help first-time parents better support each other through the often stressful transition to parenthood has a positive effect on birth outcomes as well, according to health researchers.
NIH/National Institute of Child Health and Human Development

Contact: Victoria M. Indivero
vmi1@psu.edu
814-865-9481
Penn State

Public Release: 3-Sep-2015
Gastroenterology
Novel genes found in inflammatory bowel disease under Age 5
Researchers analyzing the complicated genetic influences in inflammatory bowel disease have discovered new gene variants associated with an often-severe type of the disease that affects children under age five. The genes play important roles in immune function, and that knowledge helps guide more precise, individualized treatments for very young patients.
National Institutes of Health

Contact: John Ascenzi
ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia

Public Release: 3-Sep-2015
Molecular Cell
Team decodes structure of protein complex active in DNA repair
The multifunctional ubiquitin tweaks the activity of newly made proteins, which can influence DNA damage repair via BRCA1 and anti-inflammatory responses. One enzyme in particular, BRCC36, removes a specific type of ubiquitin central to DNA damage repair and inflammation. But BRCC36 doesn't act on its own. It's part of a complex with KIAA0157. How these two work together is finally coming into focus.
NIH/National Cancer Institute, NIH/National Institute of General Medical Sciences, Harrington Discovery Institute Scholar-Innovator Award, Abramson Family Cancer Research Institute, Basser Center for BRCA, Canadian Institutes of Health Research

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Public Release: 3-Sep-2015
Anesthesiology
Emotional behavior altered after multiple exposures to anesthesia during infancy
Repeated exposure to anesthesia early in life causes alterations in emotional behavior that may persist long-term, according to a study from the Icahn School of Medicine at Mount Sinai in collaboration with the Yerkes National Primate Research Center, and published in the Online First edition of Anesthesiology, the official medical journal of the American Society of Anesthesiologists®.
NIH/National Institute of Child Health and Human Development

Contact: Elizabeth Dowling
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine

Public Release: 3-Sep-2015
Science
Immune cells take cue from animal kingdom: Together, everyone achieves more
Much like birds fly in flocks to conserve energy and ants create complex nests to protect their queens, immune cells engage in coordinated behavior to wipe out viruses like the flu. Scientists discovered that cells called neutrophils arrive at the site of injury within an hour of infection and leave a chemical 'trail' behind them. Killer immune cells called T cells use this trail to find the site of injury and destroy the invader.
National Institutes of Health

Contact: Emily Boynton
emily_boynton@urmc.rochester.edu
585-704-6516
University of Rochester Medical Center

Public Release: 2-Sep-2015
Neuron
Reward, aversion behaviors activated through same brain pathways
New research at Washington University School of Medicine in St. Louis may help explain why drug treatments for addiction and depression don't work for some patients. The conditions are linked to reward and aversion responses in the brain. And the research suggests that some treatments simultaneously stimulate reward and aversion responses, resulting in a net zero effect.
NIH/National Institute on Drug Abuse, NIH/National Institute on Neurological Disorders and Stroke NIH/National Institute of Diabetes and Digestive and Kidney Diseases

Contact: Jim Dryden
jdryden@wustl.edu
314-286-0110
Washington University School of Medicine

Public Release: 2-Sep-2015
Psychological Science
Who gets a transplant organ
A Rutgers study examines how decisions are made when it comes to allocating scare resources. Imagine 12 patients who need new kidneys, and six kidneys available. How would you allocate them? New research by Rutgers social psychologists suggests your answer would depend on how the patients and their situations are presented to you.
NIH/National Institute on Aging

Contact: Ken Branson
kbranson@ucm.rutgers.edu
848-932-0580
Rutgers University

Public Release: 2-Sep-2015
Gastroenterology
Researchers identify a new approach for lowering harmful lipids
Xian-Cheng Jiang, Ph.D., professor of cell biology at SUNY Downstate Medical Center, has led a study identifying a new approach for lowering 'bad' lipids in blood circulation, a critical means to combat devastating cardiovascular diseases such as atherosclerosis.
US Department of Veterans Affairs, National Institutes of Health, American Heart Assocation

Contact: Ron Najman
ron.najman@downstate.edu
718-270-2696
SUNY Downstate Medical Center

Public Release: 2-Sep-2015
Journal of Neuroscience
Texas A&M team finds neuron responsible for alcoholism
Scientists have pinpointed a population of neurons in the brain that influences whether one drink leads to two, which could ultimately lead to a cure for alcoholism and other addictions. A study, published in the Journal of Neuroscience by researchers at the Texas A&M Health Science Center College of Medicine, finds that alcohol consumption alters the structure and function of neurons in the dorsomedial striatum, a part of the brain known to be important in goal-driven behaviors
NIH/National Institute on Alcohol Abuse and Alcoholism, 2014 John P. McGovern Award from the Texas Research Society on Alcoholism

Contact: Holly Shive
hshive@tamhsc.edu
979-436-0613
Texas A&M University

Public Release: 2-Sep-2015
Journal of Hepatology
WSU scientists discover mechanism for air pollution-induced liver disease
A research team led by Kezhong Zhang, Ph.D., at the Wayne State University School of Medicine's Center for Molecular Medicine and Genetics, has discovered that exposure to air pollution has a direct adverse health effect on the liver and causes liver fibrosis, an illness associated with metabolic disease and liver cancer.
NIH/National Environmental Health Science Institute, NIH/National Institute of Diabetes and Digestive and Kidney Disease, American Heart Association

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research

Public Release: 2-Sep-2015
Proceedings of the National Academy of Sciences
Columbia Engineering team develops targeted drug delivery to lung
Researchers from Columbia Engineering and Columbia University Medical Center have developed a new method that can target delivery of very small volumes of drugs into the lung. Their approach, in which micro-liters of liquid containing a drug are instilled into the lung, distributed as a thin film in the predetermined region of the lung airway, and absorbed locally, may provide much more effective treatment of lung disease.
National Institutes of Health, Raymond and Beverly Sackler Foundation, Mikati Family Fund for Translational Research in Biomedical Engineering

Contact: Holly Evarts
holly.evarts@columbia.edu
347-453-7408
Columbia University School of Engineering and Applied Science

Public Release: 2-Sep-2015
American Journal of Pathology
Newly discovered protein may protect kidney cells from injury
A new discovery by Boston University School of Medicine (BUSM) researchers may change how kidney disease is treated in the future. The previously unknown protein transmembrane and immunoglobulin containing 1 (TMIGD1) involved in protecting kidney epithelial cells (cells critical to normal kidney function) from injury, could be a novel target for restoring kidney function from various forms of kidney disease. The findings are published online in the American Journal of Pathology.
National Institutes of Health

Contact: Kristen Perfetuo
kristenp@bu.edu
617-638-8484
Boston University Medical Center

Public Release: 2-Sep-2015
Menopause
New symptom may help ID sleep apnea in older women
Obstructive sleep apnea may be underdiagnosed in postmenopausal women. A new study strongly associates the condition's traditional risk factors with nocturnal enuresis (bedwetting), suggesting that it may be an additional screening factor for doctors to consider.
National Institutes of Health

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University

Public Release: 2-Sep-2015
Science Signaling
New genetic mutation identified in melanoma cancer cells
There is strong evidence that the protein complex APC/C may function as a tumor suppressor in multiple cancers including lymphoma, colorectal and breast cancer, and now melanoma. A new study has revealed that a genetic mutation leading to repression of a specific protein, Cdh1, which interacts with APC/C, is present in melanoma cancer cells.
National Institutes for Health, NIH/National Cancer Institute

Contact: Kristen Perfetuo
kristenp@bu.edu
617-638-8484
Boston University Medical Center

Public Release: 2-Sep-2015
eLife
Cellular recycling complexes may hold key to chemotherapy resistance
Upsetting the balance between protein synthesis, misfolding, and degradation drives cancer and neurodegeneration. Recent cancer treatments take advantage of this knowledge with a class of drugs that block protein degradation, known as proteasome inhibitors. Widespread resistance to these drugs limits their success, but Whitehead researchers have discovered a potential Achilles heel in resistance. With such understandings researchers may be able to target malignancy broadly, and more effectively.
EMBO, Charles A. King Trust, Koch Institute Frontier Research Program, Kathy and Curt Marble Cancer Research Fund, Alexander and Margaret Stewart Trust, National Institutes of Health, Valvano Foundation

Contact: Nicole Giese Rura
rura@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research

Public Release: 2-Sep-2015
PLOS ONE
Driving with central visual field loss
Vision researchers in Boston have published the second paper of a study designed to determine if a driver who suffers from loss of central vision is able to detect pedestrians in a timely manner when driving. The results of the current study showed that a blind area located above or below the center of interest will still likely block or delay a driver's ability to detect pedestrians entering the field of vision from the side of the road.
National Institutes of Health

Contact: Joseph O'Shea
joseph_oshea@meei.harvard.edu
617-573-3341
Massachusetts Eye and Ear Infirmary

Showing releases 1-25 out of 3756.

1 | 2 | 3 | 4 | 5 > >>

     
   

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