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Department of Health and Human Services

News from the National Institutes of Health

Funded News


Key: Meeting M      Journal J      Funder F

Showing releases 1-25 out of 3591.

1 | 2 | 3 | 4 | 5 > >>

Public Release: 5-Mar-2015
Science
Transport molecule forms a protective structure to guide proteins to cell membrane
The molecular complex that guides an important class of proteins to correct locations in cell membranes does so by forming a dimeric structure with a protective pocket. This structure shields tail-anchored membrane proteins -- which have roles in a wide variety of cellular functions from neurotransmitter release to insulin production -- from harmful aggregation or misfolding as they move through the inner environment of a cell. The findings clarify the mechanism behind a fundamental biological process.
National Institutes of Health, US Department of Energy, UK Medical Research Council, Chicago Biomedical Consortium

Contact: Kevin Jiang
kevin.jiang@uchospitals.edu
773-795-5227
University of Chicago Medical Center

Public Release: 5-Mar-2015
Neuron
Abnormal brain rhythms tied to problems with thinking in schizophrenia
By studying specially bred mice with specific developmental and cognitive traits resembling those seen in schizophrenia, UC San Francisco researchers have provided new evidence that abnormal rhythmic activity in particular brain cells contributes to problems with learning, attention, and decision-making in individuals with that disorder.
Staglin Family, International Mental Health Research Organization, NIH/National Institute of Mental Health, Alfred P. Sloan Foundation, National Institutes of Health, Brain and Behavior Research Foundation

Contact: Pete Farley
peter.farley@ucsf.edu
415-502-6397
University of California - San Francisco

Public Release: 5-Mar-2015
The Journals of Gerontology, Series A
If you come from a family with relatives who have lived long lives, you will too?
Recent research from the Long Life Family Study confirms that severe mortality-associated diseases are less prevalent in the families of long-lived individuals than in the general population. The Journals of Gerontology, Series A will publish these findings on March 5, 2015.
NIH/National Institute on Aging, National Institutes of Health

Contact: Tara Kennedy
tara.kennedy@oup.com
212-726-6258
Oxford University Press USA

Public Release: 5-Mar-2015
How healthy is genetically modified soybean oil?
Soybean oil accounts for more than 90 percent of all the seed oil production in the United States. Genetically modified soybean oil, made from seeds of GM soybean plants, was recently introduced into the food supply on the premise that it is healthier than conventional soybean oil. But is that premise true? Just barely, say scientists at the University of California, Riverside and their colleagues at UC Davis.
UCR Collaborative Seed Grant, UCR Agricultural Experiment Station, National Institutes of Health, National Institute of Environmental Health Sciences

Contact: Iqbal Pittalwala
iqbal@ucr.edu
951-827-6050
University of California - Riverside

Public Release: 5-Mar-2015
Chemistry & Biology
Molecule from trees helps female mice only resist weight gain
A molecule found in some plants can combat weight gain induced by a high-fat diet, but only in female mice, not males. 7,8-dihydroxyflavone (7,8-DHF) is thought to mimic the effects of a growth factor induced by exercise.
NIH/National Institute of Diabetes and Digestive and Kidney Diseases, NIH/National Institute on Deafness and Other Communication Disorders

Contact: Quinn Eastman
qeastma@emory.edu
404-727-7829
Emory Health Sciences

Public Release: 5-Mar-2015
Cell
In vivo CRISPR-Cas9 screen sheds light on cancer metastasis and tumor evolution
For the first time, CRISPR-Cas9 gene-editing technology has been employed in a whole organism model to systematically target every gene in the genome. A team of scientists have pioneered the use of this technology to 'knock out,' or turn off, all genes across the genome systematically in an animal model of cancer, revealing genes involved in tumor evolution and metastasis and paving the way for similar studies in other cell types and diseases.
National Institutes of Health, NIH/National Institute of Diabetes and Digestive and Kidney Diseases, NIH/National Institute of Mental Health

Contact: Paul Goldsmith
paulg@broadinstitute.org
617-714-8600
Broad Institute of MIT and Harvard

Public Release: 5-Mar-2015
Science
Yale researchers map 'switches' that shaped the evolution of the human brain
Thousands of genetic 'dimmer' switches, regions of DNA known as regulatory elements, were turned up high during human evolution in the developing cerebral cortex, according to new research from the Yale School of Medicine.
National Institutes of Health

Contact: Lindsay Borthwick
lindsay.borthwick@yale.edu
416-706-7522
Yale University

Public Release: 5-Mar-2015
American Heart Association's Epidemiology/Lifestyle Scientific Sessions 2015
Improving your fitness could improve your spouse's fitness
Your exercise regimen isn't just good for you; it may also be good for your spouse. New research led by the Johns Hopkins Bloomberg School of Public Health finds that if one spouse improves his or her exercise regimen, the other spouse is significantly more likely to follow suit.
NIH/National Heart, Lung, and Blood Institute

Contact: Stephanie Desmon
sdesmon1@jhu.edu
410-955-7619
Johns Hopkins University Bloomberg School of Public Health

Public Release: 5-Mar-2015
Cell Reports
Researchers discover protein's pivotal role in heart failure
Researchers at the University of California, San Diego School of Medicine have identified a key piece in the complex molecular puzzle underlying heart failure -- a serious and sometimes life-threatening disorder affecting more than 5 million Americans.
National Institutes of Health

Contact: Bonnie Ward
bjward@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 5-Mar-2015
Cell Stem Cell
Twin copies of gene pair up in embryonic stem cells at critical moment in differentiation
Researchers at CSHL have shown that the two alleles of Oct4, a gene important in embryonic stem cells, don't remain separate in the nucleus of stem cells but rather pair up, at the developmental point at which stem cells begin their maturation into specific cell types.
NIH/National Institute of General Medical Sciences, Starr Foundation

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory

Public Release: 5-Mar-2015
Journal of the National Cancer Institute
Unregulated web marketing of genetic tests for personalized cancer care raises concerns
Websites that market personalized cancer care services often overemphasize their purported benefits and downplay their limitations, and many sites offer genetic tests whose value for guiding cancer treatment has not been shown to be clinically useful, according to a new study from Dana-Farber Cancer Institute.
American Cancer Society, National Institutes of Health

Contact: Anne Doerr
anne_doerr@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute

Public Release: 5-Mar-2015
ENDO 2015: The 97th Annual Meeting & EXPO in San Diego, CA
Phthalates potentially alter levels of a pregnancy hormone that influences sex development
Exposure to hormone-altering chemicals called phthalates -- which are found in many plastics, foods and personal care products -- early in pregnancy is associated with a disruption in an essential pregnancy hormone and adversely affects the masculinization of male genitals in the baby, according to research led by the University of Pittsburgh Graduate School of Public Health. The findings focus on the role of the placenta in responding to these chemicals and altering levels of a key pregnancy hormone.
NIH/National Institute of Environmental Health Sciences

Contact: Allison Hydzik
Hydzikam@upmc.edu
412-647-9975
University of Pittsburgh Schools of the Health Sciences

Public Release: 5-Mar-2015
Exposure to endocrine disruptors during pregnancy affects the brain two generations later
Prenatal exposure to low doses of the environmental contaminants polychlorinated biphenyls, or PCBs, change the developing brain in an area involved in metabolism, and some effects are apparent even two generations later, a new study finds. Performed in rats, the research will be presented Friday at the Endocrine Society's 97th annual meeting in San Diego.
National Institutes of Health

Contact: Aaron Lohr
alohr@endocrine.org
202-971-3654
The Endocrine Society

Public Release: 4-Mar-2015
UH researchers find link between flame retardants and obesity
Could your electronics be making you fat? According to University of Houston researchers, a common flame retardant used to keep electronics from overheating may be to blame. Scientists at UH's Center for Nuclear Receptors and Cell Signaling have been researching the issue using zebrafish. Supported by a $375,209 grant from the National Institutes of Health's National Institute for Environmental Health Sciences, the researchers set out to screen for compounds that lead to obesity, called obesogens.
NIH/National Institute for Environmental Health Sciences

Contact: Lisa Merkl
lkmerkl@uh.edu
713-743-8192
University of Houston

Public Release: 4-Mar-2015
Proceedings of the National Academy of Sciences
New protein booster may lead to better DNA vaccines and gene therapy
Scientists have discovered a new way to manipulate how cells function, a finding that might help advance an experimental approach to improving public health: DNA vaccines, which could be more efficient, less expensive and easier to store than traditional vaccines. Their approach, based on research results published this week, improves upon an existing laboratory technique, transfection, widely used to study how cells and viruses work.
National Institutes of Health

Contact: Marc Airhart
mairhart@austin.utexas.edu
512-232-1066
University of Texas at Austin

Public Release: 4-Mar-2015
Experimental Biology 2015
MARC Travel Awards announced for EB 2015
FASEB MARC Program has announced the travel award recipients for the Experimental Biology 2015 meeting in Boston, Mass., from March 28-April 1, 2015. These awards are meant to promote the entry of students, post doctorates and scientists from underrepresented groups into the mainstream of the basic science community and to encourage the participation of young scientists at EB 2015.
NIH/National Institute of General Medical Sciences, National Institutes of Health

Contact: Kelly Husser
khusser@faseb.org
301-634-7109
Federation of American Societies for Experimental Biology

Public Release: 4-Mar-2015
American College of Cardiology 64th Annual Scientific Session & Expo
Omega-3 fatty acids appear to protect damaged heart after heart attack
Taking omega-3 fatty acids appeared to lower inflammation and guard against further declines in heart function among recent heart attack survivors already receiving optimal standard care, according to results from a randomized, controlled trial to be presented at the American College of Cardiology's 64th Annual Scientific Session in San Diego.
National Institutes of Health

Contact: Beth Casteel
bcasteel@acc.org
202-375-6275
American College of Cardiology

Public Release: 4-Mar-2015
Nature Communications
LSU Health New Orleans discovers retina protein that may help conquer blindness
Research led by Nicolas Bazan, M.D., Ph.D., Boyd Professor and Director of the LSU Health New Orleans Neuroscience Center of Excellence, discovered a protein in the retina that is crucial for vision. The paper reports, for the first time, the key molecular mechanisms leading to visual degeneration and blindness. The research reveals events that may be harnessed for prevention, as well as to slow down progression of retinal degenerative diseases.
National Institutes of Health, Eye Ear Nose and Throat Foundation of New Orleans, Research to Prevent Blindness

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center

Public Release: 4-Mar-2015
Genes and Development
Penn scientists describe the function of an enzyme critical to male fertility
In a study published in the journal Genes and Development, University of Pennsylvania researchers have filled in details of how an enzyme, through interactions with a network of nearly two dozen other genes, protects the integrity of the germ line by giving rise to a class of RNA molecules that are essential to sperm development.
Brody Family Fellowship, National Institutes of Health, National Natural Science Foundation of China, Nanjing Medical University Startup Funding

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania

Public Release: 4-Mar-2015
Nature
Using fruit flies to understand how we sense hot and cold
Innately, we pull our hand away when we touch a hot pan on the stove, but little is known about how our brain processes temperature information. Northwestern University scientists now have discovered how a fruit fly's brain represents temperature, mapping it neuron by neuron, which has implications for understanding the much more complex human brain and how it responds to sensory stimuli. The work represents the first comprehensive mapping of the brain circuit that processes temperature information in any animal.
National Institutes of Health

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University

Public Release: 4-Mar-2015
New England Journal of Medicine
L.A. story: Cleaner air, healthier kids
A 20-year study shows that decreasing air pollution in Los Angeles has led to healthier lungs for millennials when compared to children in the '90s.
Health Effects Institute, California Air Resources Board, Hastings Foundation, NIH/National Institute of Environmental Health Sciences

Contact: Carl Marziali
marziali@usc.edu
213-740-4751
University of Southern California

Public Release: 4-Mar-2015
Science Translational Medicine
Common antidepressant may hold the key to heart failure reversal
A team led by researchers at Temple University School of Medicine found that a commonly prescribed antidepressant restored heart function in mice with heart failure, a finding that could lead to clinical trials for a disease long considered irreversible. The team, which was led by Walter J. Koch, PhD, the William Wikoff Smith Endowed Chair in Cardiovascular Medicine at TUSM, found that the antidepressant paroxetine (also known as Paxil), reversed heart failure in mice.
Brody Family Medical Trust Fund Fellowship, National Institutes of Health

Contact: Jeremy Walter
Jeremy.Walter@tuhs.temple.edu
267-838-0398
Temple University Health System

Public Release: 4-Mar-2015
Neuron
Study reveals mechanism behind most common form of inherited Alzheimer's disease
A study from researchers at Massachusetts General Hospital and Brigham and Women's Hospital reveals for the first time exactly how mutations associated with the most common form of inherited Alzheimer's disease produce the disorder's devastating effects. The paper upends conventional thinking about the effects of Alzheimer's-associated mutations in the presenilin genes and provides an explanation for the failure of drugs designed to block presenilin activity.
NIH/National Institute for Neurological Disorders and Stroke, Alzheimer's Association, Pew Scholars Program in the Biomedical Sciences

Contact: Terri Ogan
togan@partners.org
617-726-0954
Massachusetts General Hospital

Public Release: 3-Mar-2015
Journal of Medical Internet Research
Twitter helps smokers kick the habit, UCI-Stanford study finds
When subjects in a smoking cessation program tweet each other regularly, they're more successful at kicking the habit, according to a study by UC Irvine and Stanford University researchers. Specifically, daily 'automessages' that encourage and direct the social media exchanges may be more effective than traditional social media interventions for quitting smoking.
NIH/National Institute on Drug Abuse, NIH/National Institute of Mental Health

Contact: Anne Warde
awarde@uci.edu
949-824-7922
University of California - Irvine

Public Release: 3-Mar-2015
Molecular Pharmacology
UC Davis scientists describe novel drug mechanism that fights brain cancer
Researchers at UC Davis have developed and characterized a molecule that interferes with the internal regulation of cancer cells, causing them to self-destruct.
National Institutes of Health, Neurological Sciences, UC Davis Research Investments in Science and Engineering, MIND Institute Intellectual and Developmental Disabilities Research Center

Contact: Dorsey Griffith
dorsey.griffith@ucdmc.ucdavis.edu
916-734-9118
University of California - Davis Health System

Showing releases 1-25 out of 3591.

1 | 2 | 3 | 4 | 5 > >>

     
   

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