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Department of Health and Human Services

News from the National Institutes of Health

Funded News


Key: Meeting M      Journal J      Funder F

Showing releases 101-125 out of 3715.

<< < 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 > >>

Public Release: 14-May-2015
Science
Mayo Clinic: New mouse model for ALS and frontotemporal dementia gene
Researchers at Mayo Clinic in Florida have developed a mouse model that exhibits the neuropathological and behavioral features associated with the most common genetic form of amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease) and frontotemporal dementia, which are caused by a mutation in the C9ORF72 gene.
NIH/National Institute on Aging, NIH/National Institute of Neurological Disorders and Stroke, Mayo Graduate School, ALS Association, Robert Packard Center for ALS Research at Johns Hopkins, Target ALS

Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-0746
Mayo Clinic

Public Release: 14-May-2015
Molecular Cell
Scientists discover how a promising anti-leukemia drug harms cancer cells
Due to overwhelming evidence of their effectiveness in mice, inhibitors of the leukemia protein BRD4, including the drug JQ1, moved into clinical trials starting in 2013. There are 12 trials targeting BRD4 in progress. Last year, clinical trial findings indicated that an oral inhibitor of BRD4 similar to JQ1 had led to complete remission in some patients. Now a team at CSHL has determined the pathway through which JQ1 acts.
National Institutes of Health, Alex's Lemonade Stand Foundation, V Foundation, Martin Sass Foundation, Lauri Strauss Leukemia Foundation, Burroughs Wellcome Fund, Japan Society for the Promotion of Science, Boehringer Ingelheim Fonds

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory

Public Release: 13-May-2015
Cell, Host & Microbe
New insight into inflammatory bowel disease may lead to better treatments
A newly discovered link between bacteria and immune cells sheds light on inflammatory bowel disease, an autoimmune condition that affects 1.6 million people in the United States, according to researchers at Washington University School of Medicine in St. Louis.
NIH/ National Institute of Diabetes and Digestive and Kidney Diseases, NIH/National Institute of Child Health and Human Development,

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine

Public Release: 13-May-2015
2015 American Society of Clinical Oncology Annual Meeting
Variations in liver cancer attributable to hepatitis virus variations
Significant clinical variations exist among patients with the most common type of liver cancer called hepatocellular carcinoma, depending on the viral cause of the disease --hepatitis B virus or hepatitis C virus. These differences suggest that hepatitis status should be considered when developing treatment plans for newly diagnosed patients, according to researchers at The University of Texas MD Anderson Cancer Center.
National Institutes of Health

Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center

Public Release: 13-May-2015
Journal of National Cancer Institute
Protein FGL2 may have potential as therapy target for brain cancer
Blocking FGL2, a protein known to promote cancer, may offer a new strategy for treating brain cancer, according to a study at The University of Texas MD Anderson Cancer Center.
National Institutes of Health

Contact: Ron Gilmore
rlgilmore1@mdanderson.org
713-745-1898
University of Texas M. D. Anderson Cancer Center

Public Release: 13-May-2015
Mayo Clinic to study 10,000 patients for drug-gene safety
Mayo Clinic, in collaboration with Baylor College of Medicine, is planning to launch a study of 10,000 Mayo biobank members for potential risk of drug reactions or lack of drug effect based on each individual's genome.
Mayo Clinic Biobank, Pharmacogenomics Research Network, NIH/National Institute of General Medical Sciences

Contact: Bob Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic

Public Release: 13-May-2015
Educational Researcher
Caution urged in using measures of students' 'non-cognitive' skills for teacher evaluation, school accountability, or student diagnosis
Policymakers and practitioners have grown increasingly interested in measures of personal qualities other than cognitive ability -- including self-control, grit, growth mindset, gratitude, purpose, emotional intelligence, and other beneficial personal qualities -- that lead to student success. However, they need to move cautiously before using existing measures to evaluate educators, programs, and policies, or diagnosing children as having 'non-cognitive' deficits, according to a review published in a peer-reviewed journal of the American Educational Research Association.
NIH/National Institute on Aging, Character Lab, Bill and Melinda Gates Foundation, Robert Wood Johnson Foundation, Spencer Foundation, John Templeton Foundation, Raikes Foundation, William T. Grant Foundation, and others

Contact: Tony Pals
tpals@aera.net
202-238-3233
American Educational Research Association

Public Release: 13-May-2015
European Journal of Epidemiology
No link found between PTSD and cancer risk
In the largest study to date that examines post-traumatic stress disorder (PTSD) as a risk factor for cancer, researchers from Boston University School of Medicine, have shown no evidence of an association.
NIH/National Institute of Mental Health

Contact: Gina DiGravio
ginad@bu.edu
617-638-8480
Boston University Medical Center

Public Release: 13-May-2015
Drug and Alcohol Dependence
'Extreme' exposure to secondhand cannabis smoke causes mild intoxication
Secondhand exposure to cannabis smoke under 'extreme conditions,' such as an unventilated room or enclosed vehicle, can cause nonsmokers to feel the effects of the drug, have minor problems with memory and coordination, and in some cases test positive for the drug in a urinalysis. Those are the findings of a Johns Hopkins University School of Medicine study, reported online this month in the journal Drug and Alcohol Dependence.
Substance Abuse and Mental Health Services Administration, NIH/National Center for Research Resources

Contact: Heather Dewar
hdewar@jhmi.edu
410-502-9463
Johns Hopkins Medicine

Public Release: 13-May-2015
Journal of the American Heart Association
Long-term depression may double stroke risk for middle-aged adults
Adults over 50 who have persistent symptoms of depression may have twice the risk of stroke as those who do not, according to a new study led by researchers at Harvard T.H. Chan School of Public Health. Researchers found that stroke risk remains higher even after symptoms of depression go away, particularly for women.
NIH/Eunice Kennedy Shriver National Institute for Child Health and Human Development, NIH/National Institute of Neurological Disorders and Stroke

Contact: Todd Datz
tdatz@hsph.harvard.edu
617-432-8413
Harvard School of Public Health

Public Release: 13-May-2015
Cell Host & Microbe
TSRI scientists identify interferon beta as likely culprit in persistent viral infections
Interferon proteins are normally considered virus-fighters, but scientists at The Scripps Research Institute have found evidence that one of them, interferon beta, has an immune-suppressing effect that can help some viruses establish persistent infections.
National Institutes of Health, American Heart Association

Contact: Madeline McCurry-Schmidt
madms@scripps.edu
858-784-9254
Scripps Research Institute

Public Release: 13-May-2015
Science Translational Medicine
New blood test quickly reveals severity of radiation injury
A novel blood test could greatly improve triage of victims of radiation accidents by rapidly predicting who will survive, who will die, and who should receive immediate medical countermeasures, according to scientists at Dana-Farber Cancer Institute.
National Institutes of Health, American Cancer Society

Contact: Anne Doerr
anne_doerr@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute

Public Release: 13-May-2015
New England Journal of Medicine
X-linked gene mutations cause some cases of male infertility, Pitt study says
Some cases of male infertility are due to mutations in the maternal X chromosome that prevent development of viable sperm, according to a study led by researchers at the University of Pittsburgh School of Medicine and the Magee-Womens Research Institute. The study was published online today in the New England Journal of Medicine.
NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development, Pennsylvania Department of Health, Magee-Womens Research Institute, University of Pittsburgh, Polish National Science Centre, German Research Foundation

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
University of Pittsburgh Schools of the Health Sciences

Public Release: 13-May-2015
Journal of the National Cancer Institute
How the tumor microenvironment contributes to drug-resistant neuroblastoma
Researchers at Children's Hospital Los Angeles have made an important step toward finding a target in the fight against drug-resistant neuroblastoma, the most common solid malignancy found, outside of the skull, in children.
St. Baldrick's Foundation, Pablove Foundation, National Institutes of Health, NIH/National Cancer Institute

Contact: Debra Kain
dkain@chla.usc.edu
323-361-7628
Children's Hospital Los Angeles

Public Release: 13-May-2015
New England Journal of Medicine
Penn study finds that various financial incentives help smokers quit
Four different financial incentive programs, each worth roughly $800 over six months, all help more smokers kick the habit than providing free access to behavioral counseling and nicotine replacement therapy. Further, the way in which equally sized payouts are structured influences their effectiveness. The findings are the result of a year-long randomized trial among CVS Caremark (now CVS Health) employees that was conducted by researchers at the University of Pennsylvania.
NIH/National Cancer Institute, NIH/National Institute on Aging, CVS Health

Contact: Anna Duerr
anna.duerr@uphs.upenn.edu
215-349-8369
University of Pennsylvania School of Medicine

Public Release: 13-May-2015
Neuropsychopharmacology
Brains of smokers who quit successfully might be wired for success
Smokers who are able to quit might actually be hard-wired for success, according to a study from Duke Medicine. The study, published in Neuropsychopharmacology, showed greater connectivity among certain brain regions in people who successfully quit smoking compared to those who tried and failed.
NIH/National Institute on Drug Abuse

Contact: Samiha Khanna
samiha.khanna@duke.edu
919-419-5069
Duke University Medical Center

Public Release: 13-May-2015
Journal of the American Heart Association
Long-term depression may double stroke risk despite treatment
Long-term depression may double the risk of stroke for middle-aged adults. educing symptoms of depression may not immediately reduce the elevated stroke risk.
National Institutes of Health, NIH/Eunice Kennedy Shriver National Institute for Child Health and Human Development, American Heart Association

Contact: Bridgette McNeill
bridgette.mcneill@heart.org
214-706-1135
American Heart Association

Public Release: 12-May-2015
Environmental Science and Technology
Fracking may affect air quality and human health
People living or working near active natural gas wells may be exposed to certain pollutants at higher levels than the Environmental Protection Agency considers safe for lifetime exposure. Air pollution from fracking operations may pose an under-recognized health hazard to people living near them, the researchers concluded.
NIH/National Institute of Environmental Health Sciences

Contact: Kim Anderson
kim.anderson@oregonstate.edu
541-737-8501
Oregon State University

Public Release: 12-May-2015
Oncotarget
Drug perks up old muscles and aging brains
We age, in part, because the adult stem cells in our tissues are surrounded by chemicals that prevent them from replacing damaged cells. One of these chemicals is TGF-beta1, known to depress stem cell activity. A UC Berkeley study shows that a drug that blocks TGF-beta1, which is now being tested for its anticancer properties, makes brain and muscle tissue more youthful. This is a step toward a drug cocktail that could rejuvenate aging tissue.
National Institutes of Health, California Institute for Regenerative Medicine

Contact: Robert Sanders
rlsanders@berkeley.edu
510-643-6998
University of California - Berkeley

Public Release: 12-May-2015
Proceedings of the National Academy of Sciences
Molecular switch that promotes heart cell maturation discovered
The difficulty in getting stem cells to mature into more adult-like heart cells has hindered the search for regenerative treatments for hearts damaged by disease. A molecular switch has now been discovered that appears to help embryonic heart cells switch from a glucose to fatty acid based metabolism. They become larger, stronger, and look and act like more mature heart cells. This discovery may lead to lab methods to grow heart cells that function more like those in adult hearts.
National Institutes of Health, Teitze Young Scientist Award, National Science Foundation, Hahn Family, University of Washington Stem Cell & Regenerative Medicine Research Institute

Contact: Leila Gray
leilag@uw.edu
206-685-0381
University of Washington Health Sciences/UW Medicine

Public Release: 12-May-2015
Journal of Biomedical Optics
Dartmouth team devises use of food dye, near infrared light to aid in breast resection
Investigators at t Dartmouth's Thayer School of Engineering and Norris Cotton Cancer Center devised a novel approach to perform near infrared (NIR) optical measurements of resected breast tissue after the margins have had their traditional marking by the surgeon to preserve information about their orientation for potential follow-up surgeries.
NIH/National Cancer Institute, National Institutes of Health

Contact: Kirk Cassels
603-653-6177
The Geisel School of Medicine at Dartmouth

Public Release: 12-May-2015
PLOS ONE
Huntington's disease monkeys display progressive clinical changes and neurodegeneration
A preclinical, large animal model of Huntington's disease for assessing new therapeutics, which could ultimately provide better treatment options, possibly including altering the course of the disease.
NIH/Office of Research Infrastructure Programs

Contact: Lisa Newbern
lisa.newbern@emory.edu
404-727-7709
Emory Health Sciences

Public Release: 12-May-2015
Future of Food Summit
World's largest dietary intervention study of cocoa flavanols
Led by JoAnn Manson, M.D., Chief, Division of Preventive Medicine at Brigham and Women's Hospital and Dr. Howard Sesso, Associate Professor of Medicine, BWH, the study reflects a cross-sector approach to public health. As elderly populations grow and length of life increases, impact of diet on health and longevity is a public health focus. The study is from a partnership among BWH, Harvard Medical School, Fred Hutchinson Cancer Research Center, NIH, Pfizer and Mars, Incorporated.
Brigham and Women's Hospital, Harvard Medical School, Fred Hutchinson Cancer Research Center, National Institutes of Health, Mars Incorporated, Pfizer Inc.

Contact: Daniella Foster
Daniella.Foster@mss.effem.com
973-691-3536
Mars Incorporated

Public Release: 12-May-2015
Cancer Research
siRNA-toting nanoparticles inhibit breast cancer metastasis
Researchers at Case Western Reserve University combined finely crafted nanoparticles with one of nature's potent disrupters to prevent the spread of triple-negative breast cancer in mouse models. The researchers are working toward clinical trials and exploring use of the technology for other cancers and diseases.
National Institutes of Health, National Science Foundation, US Department of Defense

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-534-7183
Case Western Reserve University

Public Release: 12-May-2015
American Journal of Preventive Medicine
Inconsistent Medicaid expansion would widen disparities in screenings for women's cancers
Virginia Commonwealth University Massey Cancer Center researchers recently conducted a study that found low-income and uninsured women in states that are not expanding their Affordable Care Act (ACA) Medicaid coverage are less likely to receive breast and cervical cancer screenings compared to states that are implementing expansions.
National Institutes of Health, NIH/National Cancer Institute, Office of Behavioral and Social Sciences Research, VCU Massey Cancer Center

Contact: Stevi Antosh
slantosh@vcu.edu
804-628-4578
Virginia Commonwealth University

Showing releases 101-125 out of 3715.

<< < 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 > >>

     
   

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