EurekAlert! - National Institutes of Health

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Public Release: 7-Oct-2009

Head & Neck
Rare head and neck cancer linked to HPV, study finds
An increase in cases of a rare type of head and neck cancer appears to be linked to HPV, or human papillomavirus, according to a new study from researchers at the University of Michigan Comprehensive Cancer Center.

National Institutes of Health, NIH/National Cancer Institute, others

Public Release: 7-Oct-2009
Case Western Reserve awarded $1.57M for corneal infection research
Researchers at Case Western Reserve University School of Medicine have been awarded a $1.57 million renewal grant from the National Eye Institute of the National Institutes of Health to continue their study of corneal infections, specifically, bacterial keratitis, associated with contact lens wear. The grant will extend the work initiated last year with the receipt of a $2.4 million, five-year grant from the NEI.

NIH/National Eye Institute

Public Release: 7-Oct-2009
Parents with autistic infants to try responsive teaching
While infant and toddler brains are rapidly developing, a window of opportunity exists to reduce the impact of autism, which now affects one of every 150 children born in the United States. Gerald Mahoney, director of the Center on Interventions for Children and Families at the Mandel School of Applied Social Sciences of Case Western Reserve University, received a three-year, $780,000 grant from the National Institutes of Child Health and Human Development.

NIH/National Institute of Child Health and Human Development

Public Release: 7-Oct-2009

Nature
Genome-wide study of autism published in Nature
In one of the first studies of its kind, an international team of researchers has uncovered a single-letter change in the genetic code that is associated with autism. The finding, published in the Oct. 8 issue of the journal Nature, implicates a neuronal gene not previously tied to the disorder and more broadly, underscores a role for common DNA variation.

Autism Consortium, Nancy Lurie Marks Family Foundation, NARSAD, NIH/National Center for Research Resources, NIH/National Institute of Mental Health, Simons Foundation, others

Public Release: 6-Oct-2009

Journal of Clinical Oncology
New treatment more than doubles survival for high risk childhood leukemia
Phase 2 study results show high-dose imatinib plus chemo more than doubled survival for high risk type of childhood leukemia.

NIH/National Cancer Institute

Public Release: 6-Oct-2009
$10.5 million in funding creates center to study OCD
A new research center exploring the science underlying a potential new treatment for obsessive-compulsive disorder has been established at the University of Rochester Medical Center, thanks to a $10.5 million award from the National Institute of Mental Health. Rochester will serve as the hub of a five-year collaborative effort that includes six institutions around the nation and in Puerto Rico.

NIH/National Institute of Mental Health

Public Release: 5-Oct-2009
$16M in stimulus funding launches Seattle as a hub of comparative-effectiveness research in cancer
Researchers at Fred Hutchinson Cancer Research Center, Group Health Research Institute and the University of Washington schools of Public Health and Pharmacy have been selected to lead four projects backed by approximately $16 million in federal stimulus funding for comparative-effectiveness research in cancer. The grants establish Seattle as a national hub for conducting such research.

NIH/National Cancer Institute

Public Release: 5-Oct-2009
VBI awarded $27 million from NIH to support infectious disease research
The NIAID funding will be used to integrate vital information on pathogens, provide key resources and tools to scientists, and help researchers analyze genomic, proteomic and other data arising from infectious disease research. The overall program will comprise four new Bioinformatics Resource Centers and a new gateway portal for the entire project. Each BRC will focus on one of the following pathogen types: bacterial species; viral families; protozoan species; and invertebrate vectors of human pathogens.

NIH/National Institute of Allergy and Infectious Diseases

Public Release: 5-Oct-2009

Nature Cell Biology
Wistar researchers identify gene that regulates breast cancer metastasis
Researchers at the Wistar Institute have identified a key gene (KLF17) involved in the spread of breast cancer throughout the body. They also demonstrated that expression of KLF17 together with another gene (Id1) known to regulate breast cancer metastasis accurately predicts whether the disease will spread to the lymph nodes.

Breast Cancer Alliance, Pardee Foundation, V Foundation, Pennsylvania Department of Health, NIH/National Cancer Institute, Mary Kay Ash Charitable Foundation

Public Release: 5-Oct-2009

Brain, Behavior and Immunity
Depression predicts increases in inflammatory protein linked to heart disease
Researchers led by Jesse Stewart, Ph.D., of Indiana University -- Purdue University Indianapolis report that depressive symptoms are associated with increases over time in interleukin-6, an inflammatory protein that predicts cardiovascular events. In contrast, levels of interleukin-6 were not related to later increases in depressive symptoms.

NIH/National Heart, Lung, and Blood Institute

Public Release: 5-Oct-2009
Forsyth receives highly competitive challenge grants
Four Forsyth scientists have received grants from the latest round of National Institutes of Health stimulus funding through the American Recovery and Reinvestment Act of 2009. To date, Forsyth has received 13 ARRA grants totally nearly $6.4 million. The recent round of funding includes three highly competitive "challenge grants." The NIH received 22,000 submissions in the challenge grant competition -- only about 500 were funded.

NIH/National Institute of Dental and Craniofacial Research

Public Release: 5-Oct-2009
NIH funds new phase of high school-university research partnership
A five-year-old Virginia Tech outreach program, which has more than 12,000 high school students doing research and providing results that scientists can use, has received a $1.3 million Science Education Partnership Award and a $200,000 administrative supplement to expand benefits to more students and more high schools.

NIH/National Center for Research Resources

Public Release: 5-Oct-2009
Boston University School of Medicine's Framingham Heart Study receives $1M challenge grant
Boston University School of Medicine's Framingham Heart Study has received a two-year $1 million challenge grant from the National Heart, Lung and Blood Institute.

NIH/National Heart, Lung and Blood Institute

Public Release: 5-Oct-2009

Archives of General Psychiatry
Organized phone therapy for depression found cost-effective
Significant benefits persist, with only modest cost increases, two years after people get their first session of brief, structured, phone-based cognitive behavioral psychotherapy soon after starting on antidepressant medication. This treatment is cost-effective, says a randomized trial in the October 2009 Archives of General Psychiatry. The 600-person Group Health trial is the largest to date of psychotherapy by phone -- and one of the largest studies of psychotherapy ever.

NIH/National Institute of Mental Health

Public Release: 5-Oct-2009

Annals of Internal Medicine
Stanford analyses of flu pandemics project savings from earlier vaccinations
In a city the size of New York, starting a vaccination campaign a few weeks earlier could save almost 600 lives and more than $150 million, according to a study by scientists at Stanford University School of Medicine.

Agency for Healthcare Research and Quality, NIH/National Institute on Drug Abuse

Public Release: 5-Oct-2009

Journal of Clinical Oncology
Breast reconstruction varies by race, U-M study finds
Latinas who spoke little English were less likely to undergo reconstruction surgery after a mastectomy for breast cancer, according to a study from researchers at the University of Michigan Comprehensive Cancer Center.

Robert Wood Johnson Foundation, NIH/National Cancer Institute

Public Release: 4-Oct-2009

Nature Genetics
New type of genetic change identified in inherited cancer
Duke University Medical Center and National Cancer Institute scientists have discovered that a novel genetic alteration -- a second copy of an entire gene -- is a cause of familial chordoma, an uncommon form of cancer arising in bones and frequently affecting the nervous system.

US Department of Veterans Affairs, NIH/National Cancer Institute, Chordoma Foundation

Public Release: 4-Oct-2009

Nature Medicine
Designing drugs and their antidotes together improves patient care
Imagine a surgical patient on a blood-thinning drug who starts bleeding more than expected, and an antidote that works immediately -- because the blood thinner and antidote were designed to work together. Researchers at Duke University Medical Center have engineered a way to do this for an entire, versatile class of drugs called aptamers and published their findings in Nature Medicine.

National Institutes of Health, American Heart Association, NIH/National Cancer Institute

Public Release: 3-Oct-2009

2009 AAO-HNSF Annual Meeting & OTO EXPO
Study: The new buzz on detecting tinnitus
A Henry Ford Hospital study finds that a noninvasive imaging technique can aid in the diagnosis of tinnitus and may detect a reduction in symptoms after different treatments, offering hope to the more than 50 million patients with tinnitus.

NIH/National Institute of Neurological Disorders and Stroke

Public Release: 2-Oct-2009
University of Washington receives $25 million to create Northwest Genomics Center
The National Heart, Lung, and Blood Institute announced Oct. 1 that the University of Washington will receive two of the six "Grand Opportunity" NHLBI Large-Scale DNA Sequencing Project awards. The UW will receive $25 million to launch the Northwest Genomics Center, one of two sequencing centers for the project.

NIH/National Heart, Lung, and Blood Institute

Public Release: 2-Oct-2009
USC neuroscientists awarded $9 million to map gene expression during human brain development
Two University of Southern California neuroscientists have been awarded nearly $9 million in American Recovery and Reinvestment Act funds to map how genes are expressed in different regions of the human brain throughout development.

NIH/National Institute of Mental Health

Public Release: 2-Oct-2009

Developmental Biology
Case Western Reserve University discovers Merkel cell originates from skin, not the neural crest
Case Western Reserve University School of Medicine assistant professor of pediatrics, neurosciences and otolaryngology, Stephen M. Maricich, M.D., Ph.D., and his team found that Merkel cells originate in the skin, not the neural crest lineage, as previously speculated.

NIH/National Institute of Neurological Disorders and Stroke, NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases

Public Release: 2-Oct-2009

Cancer Research
NEDD9 protein supports growth of aggressive breast cancer
Researchers at Fox Chase Cancer Center have demonstrated that a protein called NEDD9 may be required for some of the most aggressive forms of breast cancer to grow. According to the researchers, the protein could serve as a clinical biomarker to indicate the presence of aggressive forms of breast cancer. NEDD9 may also provide a target for some future therapeutic against metastatic cancer.

NIH/National Cancer Institute

Public Release: 1-Oct-2009
UF to get $64 million over 6 years to study disability prevention in older Americans
A new study called the Lifestyle Interventions and Independence for Elders, or LIFE study, will determine whether a program of structured physical activity can prevent or delay major movement disability in older adults. This phase 3 randomized controlled trial of 1,600 sedentary adults ages 70 to 89 who are at risk of mobility disability will be conducted at eight institutions around the country.

NIH/National Institute on Aging

Public Release: 1-Oct-2009
ASCB wins NIH 'stimulus grant' to build virtual library of cell images for researchers and public
A $2.5 million "stimulus grant" announced yesterday by the National Institutes of Health will enable the American Society for Cell Biology to build an unprecedented, online image library of the cell that will be readily accessible to researchers, educators, students, and the public, according to ASCB Executive Director Joan Goldberg.

National Institutes of Health, NIH/National Institute of General Medical Sciences

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