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Department of Health and Human Services

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Key: Meeting M      Journal J      Funder F

Showing releases 176-200 out of 3645.

<< < 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 > >>

Public Release: 2-Apr-2015
Anesthesia & Analgesia
WebTIPS helps make surgery less scary for children -- and their parents
A newly developed website provides parents and children with individualized information and support -- based on factors like coping style and levels of worry and fear -- to help lower anxiety before outpatient surgery in children, according to a pair of articles in the April issue of Anesthesia & Analgesia.
National Institutes of Health

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine

Public Release: 2-Apr-2015
Neurobiology of Disease
Adolescent drinking affects adult behavior through long-lasting changes in genes
Binge-drinking during adolescence may perturb brain development at a critical time and leave lasting effects on genes and behavior that persist into adulthood. The findings, by researchers at the University of Illinois at Chicago College of Medicine using an animal model, are reported online in the journal Neurobiology of Disease.
NIH/National Institute on Alcohol Abuse and Alcoholism, US Department of Veterans Affairs

Contact: Sharon Parmet
sparmet@uic.edu
312-413-2695
University of Illinois at Chicago

Public Release: 2-Apr-2015
Scientists win $3.3 million grant to speed development of treatments for autism, epilepsy
Scientists from the Florida campus of the Scripps Research Institute have been awarded $3.3 million by the National Institutes of Health to identify biomarkers to accelerate drug development for disorders including autism spectrum disorder, epilepsy and some types of intellectual disability.
NIH/National Institute of Mental Health

Contact: Eric Sauter
esauter@scripps.edu
267-337-3859
Scripps Research Institute

Public Release: 2-Apr-2015
Cellular and Molecular Gastroenterology and Hepatology
Liver injury in NASH leads to a leaky gut
Non-alcoholic steatohepatitis (NASH), the more severe form of non-alcoholic fatty liver disease that can progress to liver fibrosis and cirrhosis, is associated with leakiness of the intestinal wall, which in turn may worsen liver disease, according to research published in Cellular and Molecular Gastroenterology and Hepatology, the new basic science journal of the American Gastroenterological Association.
Sheila Sherlock Clinical and Translation Research Award, National Institutes of Health

Contact: Rachel Steigerwald
media@gastro.org
301-272-1603
American Gastroenterological Association

Public Release: 2-Apr-2015
Proceedings of the National Academy of Sciences
The brain-belly connection: Team finds genetic triggers in weight-regulating brain cells
The little voice inside your head that tells you to eat, or stop eating, isn't a little voice -- it's actually a cluster of about 10,000 specialized brain cells. And now, an international team of scientists has found tiny triggers inside those cells that give rise to this 'voice,' and keep it speaking throughout life.
NIH/National Institute of Diabetes and Digestive and Kidney Disorders

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 2-Apr-2015
New England Journal of Medicine
Some false postive prenatal genetic screens due to mother's extra DNA segments
In prenatal care, maternal blood screening for extra chromosomes in the fetus is becoming increasingly common. Such tests might give false-positive results if the mother's genome contains more than the usual number of certain DNA segments, especially if the fetus has inherited an elongated chromosome. The tests could be improved to account for the fact that chromosomes can vary in size and composition among people.
National Institutes of Health, Washington State Obstetrical Association, Howard Hughes Medical Institute

Contact: Leila Gray
leilag@uw.edu
206-685-0381
University of Washington Health Sciences/UW Medicine

Public Release: 2-Apr-2015
Cancer Letters
Nanoparticles may exploit tumor weaknesses to selectively attack cancers
Delving into the world of the extremely small, researchers are exploring how biodegradable nanoparticles can precisely deliver anticancer drugs to attack neuroblastoma, an often-deadly children's cancer. The approach may represent a new fourth arm of targeted pediatric cancer treatment, joining T-cell immunotherapy, radioactive isotopes and kinase inhibitors that disrupt cancer-driving signaling.
National Institutes of Health, Alex's Lemonade Stand Foundation, V Foundation

Contact: Rachel Salis-Silverman
Salis@email.chop.edu
267-426-6063
Children's Hospital of Philadelphia

Public Release: 2-Apr-2015
American Journal of Human Genetics
Study finds new genetic clues to pediatric seizure disorders
Researchers have identified a new genetic mutation at the heart of a severe and potentially deadly seizure disorder found in infants and young children. The finding, which was reported today in the journal American Journal of Human Genetics, may help scientists unravel the complex biological mechanism behind these diseases.
NIH/National Institutes of Neurological Disorders and Stroke

Contact: Mark Michaud
mark_michaud@urmc.rochester.edu
585-273-4790
University of Rochester Medical Center

Public Release: 2-Apr-2015
Cell Reports
Dual therapy's 1-2 punch knocks out drug-resistant lung cancer
Capitalizing on a rare opportunity to thoroughly analyze a tumor from a lung cancer patient who had developed resistance to targeted drug treatment, UC San Francisco scientists identified a biological escape hatch that explains the resistance, and developed a strategy in mice for shutting it down.
Bonnie J. Addario Lung Cancer Foundation, National Institutes of Health, Howard Hughes Medical Institute, Doris Duke Charitable Foundation, American Lung Association, Sidney Kimmel Foundation for Cancer Research, Searle Scholars Program, and others

Contact: Pete Farley
peter.farley@ucsf.edu
415-502-6397
University of California - San Francisco

Public Release: 2-Apr-2015
JAMA Ophthalmology
One test can predict which kids will become nearsighted
A study of 4,500 US children over 20 years has identified a single test that can predict which kids will become nearsighted by the eighth grade: a measure of their current refractive error.
NIH/National Eye Institute, Office of Minority Research/National Institutes of Health, Ohio Lions Eye Research Foundation, E.F. Wildermuth Foundation

Contact: Karla Zadnik
Zadnik.4@osu.edu
614-292-6603
Ohio State University

Public Release: 2-Apr-2015
Cell Stem Cell
'Open' stem cell chromosomes reveal new possibilities for diabetes
Cells of the intestine, liver and pancreas are difficult to produce from stem cells. Writing in Cell Stem Cell April 2, researchers at University of California, San Diego School of Medicine have discovered that chromosomes in laboratory stem cells open slowly over time, in the same sequence that occurs during embryonic development. It isn't until certain chromosomal regions have acquired the 'open' state that they are able to respond and become liver or pancreatic cells.
National Institutes of Health, California Institute for Regenerative Medicine, Helmsley Charitable Trust, and JDRF

Contact: Heather Buschman
hbuschman@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 2-Apr-2015
Science
Age-discrimination during cell division maintains the 'stem' in stem cells
A team of Whitehead Institute scientists has discovered that during division, stem cells distinguish between old and young mitochondria and allocate them disproportionately between daughter cells. As a result, the daughter cell destined to remain a stem cell receives predominantly young mitochondria, while the cell meant to differentiate into another cell type carries with it a higher compliment of the aged organelles.
National Institutes of Health, Foundations' Post Doc Pool, Academy of Finland, Marie Curie Actions

Contact: Matt Fearer
fearer@wi.mit.edu
617-452-4630
Whitehead Institute for Biomedical Research

Public Release: 2-Apr-2015
Science
Personalized melanoma vaccines marshal powerful immune response
Personalized melanoma vaccines can be used to marshal a powerful immune response against unique mutations in patients' tumors, according to early data in a first-in-people clinical trial at Washington University School of Medicine in St. Louis. The research is reported April 2 in Science Express, in a special issue devoted to cancer immunology and immunotherapy.
Barnes-Jewish Hospital Foundation, Siteman Cancer Frontier Fund, Our Mark on Melanoma Foundation, Come Out Swinging Foundation, Blackout Melanoma Foundation, NIH/National Cancer Institute

Contact: Jim Goodwin
jgoodwin@wustl.edu
314-286-0166
Washington University School of Medicine

Public Release: 2-Apr-2015
Stem Cell Reports
Researchers produce iPSC model to better understand genetic lung/liver disease
Using patient-derived stem cells known as induced pluripotent stem cells (iPSC) to study the genetic lung/liver disease called alpha-1 antitrypsin deficiency, researchers have for the first time created a disease signature that may help explain how abnormal protein leads to liver disease.
National Institutes of Health, Boston Medical Center, Children's Hospital of Philadelphia

Contact: Gina DiGravio
ginad@bu.edu
617-638-8480
Boston University Medical Center

Public Release: 2-Apr-2015
PLOS Biology
Pathway known to suppress tumors may also reduce burden of neurodegenerative diseases
A molecular pathway known to suppress tumors appears to also be a major player in clearing cells of damaged proteins implicated in neurodegenerative diseases such as ALS and certain types of dementia, new research in roundworms and human cells suggests.
NIH/National Institute of Neurological Disorders and Stroke, US Department of Defense, Johns Hopkins/Robert Packard Center for ALS Research, JHU-Biogen IDEC Consortium

Contact: Stephanie Desmon
sdesmon1@jhu.edu
410-955-7619
Johns Hopkins University Bloomberg School of Public Health

Public Release: 2-Apr-2015
Cell
An 'evolutionary relic' of the genome causes cancer
Pseudogenes have long been considered 'genomic junk,' mysterious remnants of evolution. Now, a scientific team in the Cancer Research Institute at Beth Israel Deaconess Medical Center has found that one of these evolutionary relics caused the development of an aggressive cancer in an animal model -- suggesting the need to sequence this vast genomic 'dark matter' in pursuit of precision cancer therapies.
National Institutes of Health, DOD Prostate Cancer Research Program, American Cancer Society, Cancer Research UK, Wellcome Trust, International Assn. for Cancer Research, Italian Assn. for Cancer Research, German Academy of Sciences Leopoldina

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center

Public Release: 1-Apr-2015
Journal of Neuroscience
LSU professor's neurological research featured in the Journal of Neuroscience
The research, jointly conducted by scientists from the Barrow Neurological Institute and Arizona State University, involves recording single-neuron activity in the brains of epilepsy patients who require electrodes implanted to monitor seizures. With the electrodes in place, processes such as perception and memory can be studied at the level of individual neurons.
Barrow Neurological Foundation, Arizona Biomedical Research Council, NIH/National Institute for Deafness and Other Communication Disorders

Contact: Tara Kistler
tkistler@lsu.edu
225-578-3869
Louisiana State University

Public Release: 1-Apr-2015
Nature
Study affirms lethal prostate cancer can spread from other metastatic sites
A new genomic analysis of tissue from patients with prostate cancer has added more evidence that cells within metastases from such tumors can migrate to other body parts and form new sites of spread on their own.
Cancer Research UK, Academy of Finland, Cancer Society of Finland, PELICAN Autopsy Study, Johns Hopkins Brady Urological Institute, John and Kathe Dyson, NIH/National Cancer Institute

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

Public Release: 1-Apr-2015
PLOS Neglected Tropical Diseases
New class of insecticides offers safer, more targeted mosquito control
Purdue researchers have identified a new class of chemical insecticides that could provide a safer, more selective means of controlling mosquitoes that transmit key infectious diseases such as dengue, yellow fever and elephantiasis.
US Department of Defense, Purdue Research Foundation, Indiana Clinical and Translational Sciences Institute, NIH/National Center for Advancing Translational Science

Contact: Natalie van Hoose
nvanhoos@purdue.edu
765-496-2050
Purdue University

Public Release: 1-Apr-2015
Science Signaling
Penn Medicine: New receptors could underlie the many actions of the anesthetic ketamine
Penn Medicine researchers are continuing their work in trying to understand the mechanisms through which anesthetics work to elicit the response that puts millions of Americans to sleep for surgeries each day. Their most recent study looked at ketamine, an anesthetic discovered in the 1960s and recently prescribed as an anti-depressant at low doses. Researchers have identified an entirely new class of receptors that ketamine binds in the body, which may underlie its diverse actions.
National Institutes of Health, Penn Nano/Bio Interface Center

Contact: Lee-Ann Donegan
leeann.donegan@uphs.upenn.edu
215-349-5660
University of Pennsylvania School of Medicine

Public Release: 1-Apr-2015
ACS Nano
A novel way to apply drugs to dental plaque
Therapeutic agents intended to reduce dental plaque and prevent tooth decay are often removed by saliva and the act of swallowing before they take effect. But a team of researchers has developed a way to keep the drugs from being washed away.
National Science Foundation, National Institutes of Health

Contact: Peter Iglinski
peter.iglinski@rochester.edu
585-273-4726
University of Rochester

Public Release: 1-Apr-2015
Journal of Neuroscience
How we hear distance: Echoes are essential for humans to perceive how far away a sound is
Mammals are good at figuring out which direction a sound is coming from, whether it's a predator breathing down our necks or a baby crying for its mother. But how we judge how far away that sound is was a mystery until now. Researchers from UConn Health report in the April 1 issue of the Journal of Neuroscience that echoes and fluctuations in volume are the cues we use to figure the distance between us and the source of a noise.
National Institutes of Health

Contact: Kim Krieger
kim.krieger@uconn.edu
860-486-0361
University of Connecticut

Public Release: 1-Apr-2015
Spine
Predicting chronic pain in whiplash injuries
While most people recover from whiplash injuries within a few months, about 25 percent have long-term pain and disability for many months or years. Using special MRI imaging, scientists identified, within the first one and two weeks of the injury, which patients will develop chronic pain and disability. This is the earliest these patients have been identified and will enable faster treatment. The imaging revealed large amounts of fat infiltrating the patients' neck muscles, indicating rapid atrophy.
National Institutes of Health

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University

Public Release: 1-Apr-2015
New England Journal of Medicine
VSV-EBOV Ebola vaccine appears safe and generates immune response
An experimental Ebola vaccine called VSV-EBOV appears safe and elicited a robust immune response in a small phase 1 clinical trial, according to findings to be published in the New England Journal of Medicine on April 2, 2015. Two independent but coordinated studies, performed at the Walter Reed Army Institute of Research and the National Institute of Allergy and Infectious Diseases, explored the safety and immunogenicity of the investigational vaccine when administered at different dosages.
NIH/National Institute of Allergy and Infectious Diseases, NIH/National Cancer Institute,Defense Threat Reduction Agency, Joint Vaccine Acquisition Program

Contact: Dr. Debra Yourick
debra.l.yourick.civ@mail.mil
301-319-9471
US Army Medical Research Institute of Infectious Diseases

Public Release: 1-Apr-2015
PLOS Pathogens
Anticancer drug can spur immune system to fight infection
Imatinib, an example of a 'targeted therapy' against cancer, or related drugs might be tools to fight a variety of infections.
NIH/National Institute of Allergy and Infectious Diseases, NIH/National Heart, Lung, and Blood Institute

Contact: Quinn Eastman
qeastma@emory.edu
404-727-7829
Emory Health Sciences

Showing releases 176-200 out of 3645.

<< < 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 > >>

     
   

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