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Department of Health and Human Services

News from the National Institutes of Health

Funded News

Key: Meeting M      Journal J      Funder F

Showing releases 201-225 out of 3603.

<< < 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 > >>

Public Release: 10-Feb-2015
Smartphone apps just as accurate as wearable devices for tracking physical activity
Although wearable devices have received significant attention for their ability to track an individual's physical activity, most smartphone applications are just as accurate, according to a new research letter in JAMA. The study tested 10 of the top-selling smartphone apps and devices in the United States by having 14 participants walk on a treadmill for 500 and 1,500 steps, each twice (for a total of 56 trials), and then recording their step counts.
NIH/National Institute on Aging, US Department of Veterans Affairs, Robert Wood Johnson Foundation

Contact: Anna Duerr
University of Pennsylvania School of Medicine

Public Release: 10-Feb-2015
Journal of Neuroscience
Protein linked to longevity and enhanced cognition protects against Alzheimer's symptoms
Scientists from the Gladstone Institutes and the University of California, San Francisco report in the Journal of Neuroscience that raising levels of the life-extending protein klotho can protect against learning and memory deficits in a mouse model of Alzheimer's disease.
NIH/National Institute of Neurological Disorders and Stroke, NIH/National Institute on Aging, American Federation of Aging Research, MetLife/AFAR Award, S.D. Bechtel, Jr. Foundation, Coulter-Weeks Foundation, Bakar Family Foundation

Contact: Dana Smith
Gladstone Institutes

Public Release: 10-Feb-2015
American Journal of Transplantation
Growing number of donor hearts rejected, need for transplants rises, Stanford study finds
Surgeons and transplant centers nationwide increasingly have rejected hearts donated for transplantation despite a growing need for them, according to a new study by researchers at the Stanford University School of Medicine.
National Institutes of Health

Contact: Tracie White
Stanford University Medical Center

Public Release: 10-Feb-2015
Molecular Cancer Therapeutics
Lung cancer may be treatable with use of SapC-DOPS technology, research shows
A University of Cincinnati study, published in the advance online edition of the journal Molecular Cancer Therapeutics, provides hope that the therapeutic agent SapC-DOPS could be used for treatment of this cancer.
NIH/National Cancer Institute, New Drug State Key Project, University of Cincinnati College of Medicine

Contact: Katie Pence
University of Cincinnati Academic Health Center

Public Release: 9-Feb-2015
Nature Communications
New screening tool could speed development of ovarian cancer drugs
Researchers have built a model system that uses multiple cell types from patients to rapidly test compounds that could block the early steps in the spread of ovarian cancer. Their 3-D cell culture system has enabled them to identify small molecules that can inhibit adhesion and invasion, hallmarks of cancer metastasis.
Bears Care, National Institutes of Health, NIH/National Cancer Institute, NIH/National Institute of Neurological Disorders and Stroke

Contact: John Easton
University of Chicago Medical Center

Public Release: 9-Feb-2015
Cell Transplantation
Akt Pathway 'ramp ups' effects of transplanted umbilical cord cells used in stroke therapy
Researchers found that transplanted human umbilical cord blood cells (HUCBCs) are beneficial in preventing neuron loss when the Akt signaling pathway is activated by HUCBC secretions, and the subsequent Akt activation impacts a specific gene involved in reducing inflammation. A reduction in inflammation helps neural cell survival following stroke. The Akt pathway has been shown to be important because it activates the peroxiredoxin 5 (Prdx5) gene, an antioxidant enzyme that reduces hydrogen peroxide and inflammation.
National Institutes of Health

Contact: Robert Miranda
Cell Transplantation Center of Excellence for Aging and Brain Repair

Public Release: 9-Feb-2015
Clinical Cancer Research
Could there be a gleevec for brain cancer?
The drug Gleevec (imatinib mesylate) is well known not only for its effectiveness against chronic myeloid leukemia (CML) and acute lymphoblastic leukemia, but also for the story behinds its development. The drug was specifically designed to target an abnormal molecule--a fusion of two normal cell proteins--that fueled a tumor's growth.
NIH/National Institute of Neurological Disorders and Stroke

Contact: Karin Eskenazi
Columbia University Medical Center

Public Release: 9-Feb-2015
Photochemical & Photobiological Sciences
NSU researchers discover DNA repair is high in heart, nonexistent in brain
Nova Southeastern University researchers recently discovered that, contrary to prior belief, tissues of different mammalian organs have very different abilities to repair damage to their DNA.
NIH/National Cancer Institute, Ruth Estrin Goldberg Foundation, and others

Contact: Jeremy Katzman, M.B.A., APR
Nova Southeastern University

Public Release: 9-Feb-2015
American Journal of Physiology
LSU Health New Orleans research finds psychedelic drug prevents asthma development in mice
Research led by Charles Nichols, Ph.D., Associate Professor of Pharmacology and Experimental Therapeutics at the LSU Health New Orleans School of Medicine, has found that a psychedelic drug, (R)-DOI, prevents the development of allergic asthma in a mouse model. The effects are potent and effective at a concentration 50-100 times less than would influence behavior.
NIH/National Heart, Lung, and Blood Institute, NIH/National Institute of Allergy and Infectious Diseases, NIH/National Institute of Environmental Health Sciences, American Asthma Foundation, Heffter Research Institute

Contact: Leslie Capo
Louisiana State University Health Sciences Center

Public Release: 9-Feb-2015
Proceedings of the National Academy of Sciences
Serotonin-deficient brains more vulnerable to social stress
Mice deficient in serotonin -- a crucial brain chemical implicated in clinical depression -- are more vulnerable than their normal littermates to social stressors, according to a Duke study in PNAS. Following exposure to stress, serotonin-deficient mice did not respond to the standard antidepressant Prozac. The results point to new strategies to help alleviate treatment-resistant depression.
National Institutes of Health, Lennon Family Foundation, Duke University's Trinity College of Arts and Sciences, Duke Institute for Brain Sciences

Contact: Karl Bates
Duke University

Public Release: 9-Feb-2015
Proceedings of the National Academy of Sciences
Nano-antioxidants prove their potential
Injectable nanoparticles that could protect an injured person from further damage due to oxidative stress have proven to be astoundingly effective in tests to study their mechanism.
DOD/Mission Connect Mild Traumatic Brain Injury Consortium, NIH/National Institutes of Health, Alliance for NanoHealth, UTHealth

Contact: David Ruth
Rice University

Public Release: 9-Feb-2015
NIH awards IU team $3.3 million in fight against antibiotic resistance
The alarming increase of antibiotic-resistant bacteria poses health and economic threats worldwide, with more than 2 million Americans infected by the bacteria each year. Now, a team of Indiana University chemists and biologists has been awarded a major grant to develop and use a chemical tagging method to better understand how bacteria build their cell wall, which is still the best target for new antibiotics.
National Institutes of Health

Contact: Steve Chaplin
Indiana University

Public Release: 9-Feb-2015
NIH grant will help understanding how connections rewire after spinal cord injury
With a nearly $1.7 million grant from the National Institutes of Health, Shelly Sakiyama-Elbert, Ph.D., at Washington University in St. Louis, is using novel methods to take a closer look at how nerve cells grow and make new connections that could restore function and movement in people with spinal cord injuries.
National Institutes of Health

Contact: Julie Flory
Washington University in St. Louis

Public Release: 9-Feb-2015
A pediatric diabetes gamechanger
UCSB and Yale University researchers receive a grant to develop an artificial pancreas for the management of Type 1 diabetes in children.
National Institutes of Health

Contact: Sonia Fernandez
University of California - Santa Barbara

Public Release: 9-Feb-2015
Annals of Internal Medicine
Lung screening guidelines improve on study findings
A set of guidelines developed to help standardized lung cancer screening would have generated considerably fewer false-positives than the National Lung Screening Trial produced, according to a new retrospective study.
National Institutes of Health

Contact: Nicole Fawcett
University of Michigan Health System

Public Release: 9-Feb-2015
Nature Genetics
Inherited gene variations tied to treatment-related hearing loss in cancer patients
St. Jude Children's Research Hospital investigators have discovered inherited genetic variations that are associated with rapid hearing loss in young cancer patients treated with the drug cisplatin. The research appears in the current online issue of the scientific journal Nature Genetics.
National Institutes of Health, ALSAC

Contact: Carrie Strehlau
St. Jude Children's Research Hospital

Public Release: 9-Feb-2015
Journal of Experimental Medicine
How tumor-causing cells are recruited in cancers linked to chronic inflammation
Chronic inflammation is directly associated with several types of cancer, yet the reasons as to why this happens at a cellular level remain unclear. Now, an international team of scientists led by researchers at The Wistar Institute has identified a multistep process showing not only how these cancers develop but also potentially discovering new therapeutic targets that could halt the formation and progression of tumor cells.
National Institutes of Health

Contact: Ben Leach
The Wistar Institute

Public Release: 9-Feb-2015
Frontiers in Human Neuroscience
Brain develops abnormally over lifespan of people who stutter
The largest-ever MRI imaging study of stuttering is the first to examine brain changes across the lifespan, says UAlberta researcher and ISTAR executive director.
SickKids Foundation, Canadian Institutes of Health Research, NIH/National Institute on Deafness and Other Communication Disorders

Contact: Bryan Alary
University of Alberta

Public Release: 9-Feb-2015
Nature Chemical Biology
Controlling genes with light
Researchers at Duke University have demonstrated a new way to activate genes with light, allowing precisely controlled and targeted genetic studies and applications. The method might be used to activate genes in a specific location or pattern, allowing more precise study of gene function, or to create complex systems for growing tissue or new therapies.
National Institutes of Health, National Science Foundation, American Heart Association

Contact: Ken Kingery
Duke University

Public Release: 9-Feb-2015
Lancet Infectious Diseases
Immune biomarkers help predict early death, complications in HIV patients with TB
Reporting in a new study published online this week in The Lancet Infectious Diseases, researchers under the Botswana-UPenn Partnership at the University of Pennsylvania have identified immune biomarkers in patients with HIV and TB before they begin ART that could help distinguish which patients go on to develop IRIS or die after treatment.
National Institutes of Health, Penn Center for AIDS Research

Contact: Steve Graff
University of Pennsylvania School of Medicine

Public Release: 9-Feb-2015
CWRU awarded $3.9 million for innovative HIV research
A researcher at Case Western Reserve University School of Medicine has been awarded $3.9 million to determine if gut leakage caused by human immunodeficiency virus leads to disease and malfunction of vital organs commonly found in HIV patients, whether drug abuse exacerbates the problem, how to fix the leaks and whether gut repair improves overall health.
NIH/National Institute on Drug Abuse

Contact: Kevin Mayhood
Case Western Reserve University

Public Release: 9-Feb-2015
Aging Cell
Mechanistic finding may help deal with side effects of lifespan-extending drug rapamycin
Rapamycin extends lifespan in mice up to 30 percent, making it of major interest to scientists studying aging. But long term use of rapamycin, approved for use in several disease indications, has side effects. Researchers at the Buck Institute have discovered new insights into how rapamycin inhibits the nutrient signaling pathway mTOR -- a finding that could provide a way to avoid or eliminate side effects of the drug.
NIH/National Institutes of Health, Ellison Medical Foundation

Contact: Kris Rebillot
Buck Institute for Age Research

Public Release: 9-Feb-2015
Nature Communications
What autism can teach us about brain cancer
Applying lessons learned from autism to brain cancer, researchers at The Johns Hopkins University have discovered why elevated levels of the protein NHE9 add to the lethality of the most common and aggressive form of brain cancer, glioblastoma. Their discovery suggests that drugs designed to target NHE9 could help to successfully fight the deadly disease.
NIH/National Institute of Neurological Disorders and Stroke, NIH/National Institute of Diabetes and Digestive and Kidney Diseases, American Heart Association, Johns Hopkins Post-Baccalaureate Research Education Program

Contact: Catherine Kolf
Johns Hopkins Medicine

Public Release: 9-Feb-2015
Journal of General Internal Medicine
Primary care-based program helps overweight, middle-aged women increase physical activity
Getting help from the family doctor may be a better way for overweight, middle-aged women to increase their physical activity, rather than trying to go it alone, according to a trial led by researchers at the University of Pittsburgh School of Medicine and funded by the National Institutes of Health.
NIH/National Hearth, Lung and Blood Institute

Contact: Rick Pietzak
University of Pittsburgh Schools of the Health Sciences

Public Release: 9-Feb-2015
Journal of Clinical Investigation
Blood vessel cells improve the conversion of pluripotent stem cells to blood lineages
A new study in the Journal of Clinical Investigation reveals that the presence of endothelial cells, which make up the lining of blood vessels, improves the ability of pluripotent stem cell-derived progenitors to repopulate blood cell lineages.
National Institutes of Health

Contact: Corinne Williams
Journal of Clinical Investigation

Showing releases 201-225 out of 3603.

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