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Showing releases 226-250 out of 3326. << < 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 > >>
Public Release: 25-Apr-2013
Nature
Bold move forward in molecular analyses
New metrics for analyzing data from small angle scattering experiments should dramatically improve the ability of scientists to study the structures of macromolecules such as proteins and nanoparticles in solution.
US Department of Energy Office of Science, National Institutes of Health
Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Public Release: 25-Apr-2013
Cell
Researchers identify key cellular organelle involved in gene silencing
How exactly microRNAs repress target gene expression is not well understood. A team of scientists led by UC Riverside geneticists has conducted a study on plants that shows that the site of action of the repression of target gene expression occurs on the endoplasmic reticulum, a cellular organelle that is an interconnected network of membranes -- essentially, flattened sacs and branching tubules -- that extends like a flat balloon throughout the cytoplasm in plant and animal cells.
National Institutes of Health, National Science Foundation, Howard Hughes Medical Institute
Contact: Iqbal Pittalwala
iqbal@ucr.edu
951-827-6050
University of California - Riverside
Public Release: 25-Apr-2013
Proceedings of the National Acadamy of Sciences
Researchers pinpoint how trees play role in smog production
After years of scientific uncertainty and speculation, researchers at the University of North Carolina at Chapel Hill show exactly how trees help create one of society's predominant environmental and health concerns: air pollution.
NIH/National Institute of Environmental Health Sciences, National Science Foundation, Electric Power Research Institute
Contact: Thania Benios
thania_benios@unc.edu
919-962-8596
University of North Carolina at Chapel Hill
Public Release: 25-Apr-2013
Neurobiology of Disease
Pitt team finds melatonin delays ALS symptom onset and death in mice
Melatonin injections delayed symptom onset and reduced mortality in a mouse model of the neurodegenerative condition amyotrophic lateral sclerosis, or Lou Gehrig's disease, according to a new study by researchers at the University of Pittsburgh School of Medicine.
NIH/National Institute of Neurological Disorders and Stroke
Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Public Release: 25-Apr-2013
Science
Missing link in Parkinson's disease found
Researchers at Washington University School of Medicine in St. Louis have described a missing link in understanding how damage to the body's cellular power plants leads to Parkinson's disease and, perhaps surprisingly, to some forms of heart failure.
NIH/National Instituties of Health
Contact: Julia Evangelou Strait
straitj@wustl.edu
314-286-0141
Washington University School of Medicine
Public Release: 25-Apr-2013
Neuron
Alzheimer's risk gene presents potential treatment target
Massachusetts General Hospital investigators have determined that one of the recently identified genes contributing to the risk of late-onset Alzheimer's disease regulates the clearance of the toxic amyloid beta protein that accumulates in the brains of patients with the disease. They also show that reducing expression of this gene in immune cells called microglia enhances their ability to clear away A-beta proteins.
Cure Alzheimer's Fund, National Institutes of Health
Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Public Release: 25-Apr-2013
Biological Psychiatry
Autism risk spotted at birth in abnormal placentas
Researchers at the Yale School of Medicine have figured out how to measure an infant's risk of developing autism by looking for abnormalities in his/her placenta at birth, allowing for earlier diagnosis and treatment for the developmental disorder. The findings are reported in the April 25 online issue of Biological Psychiatry.
National Institutes of Health, Environmental Protection Agency, MIND Institute at UC Davis, Yale
Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
Public Release: 25-Apr-2013
Cell
Potential diabetes breakthrough
Harvard Stem Cell Institute researchers have discovered a new hormone that holds promise for a dramatically more effective treatment of type 2 diabetes, a metabolic illness afflicting an estimated 26 million Americans. The researchers believe the hormone might also have a role in treating type 1, or juvenile, diabetes.
National Institutes of Health, NIH/National Institute of Mental Health
Contact: B. D. Colen
bd_colen@harvard.edu
617-413-1224
Harvard University
Public Release: 24-Apr-2013
New England Journal of Medicine
Cleveland Clinic research shows gut bacteria byproduct predicts heart attack and stroke
A microbial byproduct of intestinal bacteria contributes to heart disease and serves as an accurate screening tool for predicting future risks of heart attack, stroke and death in persons not otherwise identified by traditional risk factors and blood tests, according to Cleveland Clinic research published today in The New England Journal of Medicine.
National Institutes of Health
Contact: Laura Ambro
ambrol@ccf.org
216-636-5876
Cleveland Clinic
Public Release: 24-Apr-2013
Cancer Research
Link between inherited endocrine tumor syndrome and much-studied cell pathway
The protein menin suppresses signaling in the much-studied Hedgehog pathway in endocrine organs. Menin mutations lead to increased Hedgehog signaling and cell proliferation. Researchers found that inhibiting proteins in the Hedgehog network using drugs reduces growth of tumors in mice.
Caring for Carcinoid Foundation, NIH/National Cancer Institute
Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Public Release: 24-Apr-2013
Science Translational Medicine
Intractable seizures halted with experimental treatment for rare pediatric 'Pretzel syndrome'
With a better understanding of underlying mechanisms that cause a rare neurodevelopmental disorder in the Old Order Mennonite population, referred to as Pretzel syndrome, a new study reports that five children were successfully treated with a drug that modifies the disease process, minimizing seizures and improving receptive language. The study, by researchers including experts from the Perelman School of Medicine at the University of Pennsylvania, appears in the journal Science Translational Medicine.
National Institutes of Health
Contact: Kim Menard
kim.menard@uphs.upenn.edu
215-662-6183
University of Pennsylvania School of Medicine
Public Release: 24-Apr-2013
Journal of Neuroscience
Binge eating curbed by deep brain stimulation in animal model, Penn study shows
Deep brain stimulation (DBS) in a precise region of the brain appears to reduce caloric intake and prompt weight loss in obese animal models, according to a new study led by researchers at the University of Pennsylvania. The study, reported in the Journal of Neuroscience, reinforces the involvement of dopamine deficits in increasing obesity-related behaviors such as binge eating, and demonstrates that DBS can reverse this response via activation of the dopamine type-2 receptor.
National Institutes of Health
Contact: Kim Menard
kim.menard@uphs.upenn.edu
215-662-6183
University of Pennsylvania School of Medicine
Public Release: 24-Apr-2013
Nature Genetics
International study finds new genetic links to juvenile arthritis
Researchers report in Nature Genetics they have increased the number of confirmed genes linked to juvenile idiopathic arthritis (JIA) from three to 17 -- a finding that will clarify how JIA fits into the spectrum of autoimmune disorders and help identify potential treatment targets. Published April 21, the study involves an international research team that analyzed 2,816 JIA cases recruited from more than 40 pediatric rheumatology clinics.
National Institutes of Health, Arthritis Foundation, Val A. Browning Charitable Trust
Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Public Release: 24-Apr-2013
Nature
After brain injury, new astrocytes play unexpected role in healing
The production of a certain kind of brain cell that had been considered an impediment to healing may actually be needed to staunch bleeding and promote repair after a stroke or head trauma, researchers at Duke Medicine report.
National Biomedical Technology Resource Center, National Institutes of Health
Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center
Public Release: 24-Apr-2013
JAMA Psychiatry
Psychopaths are not neurally equipped to have concern for others
Prisoners who are psychopaths lack the basic neurophysiological "hardwiring" that enables them to care for others, according to a new study by neuroscientists at the University of Chicago and the University of New Mexico. "A marked lack of empathy is a hallmark characteristic of individuals with psychopathy," said the lead author of the study, Jean Decety, the Irving B. Harris Professor in Psychology and Psychiatry at UChicago.
NIH/National Institutes of Mental Health and the National Institute on Drug Abuse
Contact: William Harms
w-harms@uchicago.edu
773-702-8356
University of Chicago
Public Release: 24-Apr-2013
PLOS ONE
Discovery of wound-healing genes in flies could mitigate human skin ailments
Biologists at UC San Diego have identified eight genes never before suspected to play a role in wound healing that are called into action near the areas where wounds occur.
National Institutes of Health
Contact: Kim McDonald
kmcdonald@ucsd.edu
858-534-7572
University of California - San Diego
Public Release: 24-Apr-2013
American Society of Pediatric Hematology Oncology 26th Annual Meeting
Delays in diagnosis worsen outlook for minority, uninsured pediatric retinoblastoma patients
When the eye cancer retinoblastoma is diagnosed in racial and ethnic minority children whose families don't have private health insurance, it often takes a more invasive course than in other children, probably because of delays in diagnosis, according to researchers at Dana-Farber/Children's Hospital Cancer Center in Boston.
NIH/National Cancer Institute
Contact: Irene Sege
irene.sege@childrens.harvard.edu
617-919-7379
Dana-Farber Cancer Institute
Public Release: 24-Apr-2013
Journal of Neuroscience
Animal study finds deep brain stimulation reduces binge eating behavior
Stimulating a region of the brain known to be involved in reward decreases binge eating behavior in mice, according to a study published in the April 24 issue of the Journal of Neuroscience. The findings add to a growing body of evidence supporting the role of the brain's reward system in driving the consumption of palatable food. It could one day pave the way for more effective and lasting treatments for obesity.
NIH/National Institute on Drug Abuse, NIH/National Heart, Lung, and Blood Institute
Contact: Kat Snodgrass
media@sfn.org
Society for Neuroscience
Public Release: 24-Apr-2013
Journal of Clinical Investigation
No rebirth for insulin secreting pancreatic beta cells
In this issue of the Journal of Clinical Investigation, George Gittes and colleagues at the Children's Hospital of Pittsburgh used a fluorescent cell labeling method in mice to determine exactly when precursor cells develop into pancreatic beta cells.
National Institutes of Health, Children's Hospital of Pittsburgh
Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Public Release: 23-Apr-2013
Journal of Neuroscience
Anti-smoking ads with strong arguments, not flashy editing, trigger part of brain involving behavior change
Smokers who viewed ads with strong arguments had significantly less nicotine metabolites in their urine when tested a month after viewing ads.
NIH/National Institute on Drug Abuse
Contact: Steve Graff
stephen.graff@uphs.upenn.edu
215-349-5653
University of Pennsylvania School of Medicine
Public Release: 23-Apr-2013
Journal of Neuroscience
Brain biology tied to social reorientation during entry to adolescence
A specific region of the brain is in play when children consider their identity and social status as they transition into adolescence -- that often-turbulent time of reaching puberty and entering middle school, says a University of Oregon psychologist.
National Institutes of Health
Contact: Jim Barlow
jebarlow@uoregon.edu
541-346-3481
University of Oregon
Public Release: 23-Apr-2013
Gastroenterology
Team deploys hundreds of tiny untethered surgical tools in first animal biopsies
Using swarms of untethered grippers, each as small as a speck of dust, engineers and physicians have devised a new way to perform biopsies that could provide a more effective way to access narrow conduits in the body as well as find early signs of cancer or other diseases.
National Institutes of Health, National Science Foundation, Flight Attendants Medical Research Institute
Contact: Phil Sneiderman
prs@jhu.edu
443-287-9960
Johns Hopkins University
Public Release: 23-Apr-2013
Experimental Biology and Medicine
Epoxide hydrolase inhibition and Thiazolidinediones: A therapy for cardiometabolic syndrome
Scientists at the Medical College of Wisconsin and the University of California at Davis, led by Dr. John Imig and Dr. Bruce Hammock determined the synergistic actions of inhibiting soluble epoxide hydrolase with tAUCB and activating peroxisome proliferator-activator receptorγ with the thiazolidinedione rosiglitazone on the pathological progression of cardiometabolic syndrome. Cardiometabolic syndrome occurs with obesity and hypertension increasing risks for cardiovascular disease and causing significant, rapidly progressive kidney disease.
National Institutes of Health, NIH/National Institute of Environmental Health Sciences
Contact: John Imig
jdimig@mcw.edu
Society for Experimental Biology and Medicine
Public Release: 23-Apr-2013
EMBO Molecular Medicine
Researchers identify new pathway, enhancing tamoxifen to tame aggressive breast cancer
Tamoxifen is a time-honored breast cancer drug used to treat millions of women with early-stage and less-aggressive disease, and now a University of Rochester Medical Center team has shown how to exploit tamoxifen's secondary activities so that it might work on more aggressive breast cancer.
National Institutes of Health, Susan G. Komen for the Cure, US Department of Defense, NYSTEM
Contact: Leslie Orr
leslie_orr@urmc.rochester.edu
University of Rochester Medical Center
Public Release: 23-Apr-2013
PLOS Medicine
Researchers observe an increased risk of cancer in people with history of non-melanoma skin cancer
Researchers found that people with a history of non-melanoma skin cancer had a modestly increased risk of getting cancer in the future, specifically breast and lung cancer in women and melanoma in both men and women.
National Institutes of Health
Contact: Marjorie Montemayor-Quellenberg
mmontemayor-quellenberg@partners.org
617-534-2208
Brigham and Women's Hospital
Showing releases 226-250 out of 3326. << < 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 > >>
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