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Department of Health and Human Services

News from the National Institutes of Health

Funded News


Key: Meeting M      Journal J      Funder F

Showing releases 26-50 out of 3436.

<< < 1 | 2 | 3 | 4 | 5 | 6 > >>

Public Release: 25-Jul-2014
Cancer Research
Total darkness at night is key to success of breast cancer therapy -- Tulane study
Exposure to light at night, which shuts off nighttime production of the hormone melatonin, renders breast cancer completely resistant to tamoxifen, a widely used breast cancer drug, says a new study by Tulane University School of Medicine cancer researchers.
National Institutes of Health, American Association for Laboratory Animal Science, Edmond and Lily Safra Endowed Chair for Breast Cancer Research at Tulane Cancer Center

Contact: Arthur Nead
anead@tulane.edu
504-247-1443
Tulane University

Public Release: 25-Jul-2014
Cancer Research
Exposure to dim light at night may make breast cancers resistant to tamoxifen
For rats bearing human breast tumors, exposure to dim light at night made the tumors resistant to the breast cancer drug tamoxifen, according to data published in Cancer Research, a journal of the American Association for Cancer Research. The negative effects of dim light exposure on tamoxifen treatment were overcome by giving rats a melatonin supplement during the night.
National Institutes of Health, American Association for Laboratory Animal Science

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

Public Release: 25-Jul-2014
Journal of Clinical Investigation
Study shows epigenetic changes can drive cancer
Researchers at the United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center at Baylor College of Medicine and Texas Children's Hospital have now created a mouse model providing the first in vivo evidence that epigenetic alterations alone can cause cancer. Their report appears today in the Journal of Clinical Investigation.
Sidney Kimmel Foundation, US Department of Agriculture, March of Dimes, NIH/National Institute of Diabetes and Digestive and Kidney Diseases

Contact: Dipali Pathak
pathak@bcm.edu
713-798-4710
Baylor College of Medicine

Public Release: 24-Jul-2014
Journal of Neuropsychology
Experiences at every stage of life contribute to cognitive abilities in old age
Early life experiences, such as childhood socioeconomic status and literacy, may have greater influence on the risk of cognitive impairment late in life than such demographic characteristics as race and ethnicity, a large study by researchers with the UC Davis Alzheimer's Disease Center and the University of Victoria, Canada, has found.
NIH/National Institure on Aging, Canadian Institutes of Health

Contact: Phyllis Brown
phyllis.bronw@ucdmc.ucdavis.edu
916-734-9023
University of California - Davis Health System

Public Release: 24-Jul-2014
eLife
It takes two to court
Researchers at the Stowers Institute for Medical Research, have identified the functions of two classes of pheromone receptors, and found pheromones crucial to triggering the mating process in mice.
The Stowers Institute for Medical Research, Howard Hughes Medical Institute, Japan Society for the Promotion of Science, NIH/National Institute on Deafness and Other Communication Disorders o

Contact: Kim Bland
ksb@stowers.org
816-926-4015
Stowers Institute for Medical Research

Public Release: 24-Jul-2014
Pediatrics
Overweight and obese preschoolers lose more weight when parent is also treated
Primary care treatment of overweight and obese preschoolers works better when treatment targets both parent and child compared to when only the child is targeted.
National Institutes of Health

Contact: Ellen Goldbaum
goldbaum@buffalo.edu
716-645-4605
University at Buffalo

Public Release: 24-Jul-2014
Nature Nanotechnology
New imaging agent provides better picture of the gut
A multi-institutional team of researchers has developed a new nanoscale agent for imaging the gastrointestinal (GI) tract. This safe, noninvasive method for assessing the function and properties of the GI tract in real time could lead to better diagnosis and treatment of gut diseases.
National Institutes of Health, US Department of Defense, Korean Ministry of Science

Contact: Weibo Cai
wcai@uwhealth.org
608-262-1749
University of Wisconsin-Madison

Public Release: 24-Jul-2014
PLOS ONE
Immune response may cause harm in brain injuries, disorders
Could the body's own immune system play a role in memory impairment and cognitive dysfunction associated with conditions like chronic epilepsy, Alzheimer's dementia and concussions? Cleveland Clinic researchers believe so, based on a study published online by PLOS ONE.
National Institutes of Health, American Heart Association, Brain Behavior Research Foundation

Contact: Tracy Wheeler
wheelet2@ccf.org
216-444-4235
Cleveland Clinic

Public Release: 24-Jul-2014
American Journal of Epidemiology
Joblessness could kill you, but recessions could be good for your health
While previous studies of individuals have shown that employees who lose their jobs have a higher mortality rate, more comprehensive studies have shown, unexpectedly, that population mortality actually declines as unemployment rates increase. Researchers from Drexel University and the University of Michigan in Ann Arbor set out to better understand these seemingly contradictory findings.
NIH/National Institute of Child Health and Human Development

Contact: Alex McKechnie
ahm62@drexel.edu
215-895-2705
Drexel University

Public Release: 24-Jul-2014
Cell Stem Cell
Whitehead Institute researchers create 'naïve' pluripotent human embryonic stem cells
Embryonic stem cell research has been hampered by the inability to transfer research and tools from mouse ESC studies to their human counterparts, in part because human ESCs are 'primed' and slightly less plastic than the mouse cells. Now researchers in the lab of Whitehead Institute Founding Member Rudolf Jaenisch have discovered how to manipulate and maintain human ESCs into a 'na´ve' or base pluripotent state similar to that of mouse ESCs without the use of any reprogramming factors.
Simons Foundation, National Institutes of Health, Sir Henry Wellcome Postdoctoral Fellowship, Boehringer Ingelheim Fonds PhD Fellowship, Jerome and Florence Brill Graduate Student Fellowship

Contact: Nicole Giese Rura
rura@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research

Public Release: 24-Jul-2014
Oncotarget
Metastatic brain tumor treatment could be on the horizon with use of SapC-DOPS
A Cincinnati Cancer Center study, published in the advance online edition of the journal Oncotarget, provides hope that previously studied SapC-DOPS could be used for treatment of brain cancer that has spread.
UC Brain Tumor Molecular Therapeutics Program, UC College of Medicine, National Institutes of Health, New Drug State Key Project

Contact: Katie Pence
katie.pence@uc.edu
513-558-4561
University of Cincinnati Academic Health Center

Public Release: 24-Jul-2014
Nature Communications
One route to malaria drug resistance found
Researchers have uncovered a way the malaria parasite becomes resistant to an investigational drug. The discovery, at Washington University School of Medicine in St. Louis, also is relevant for other infectious diseases including bacterial infections and tuberculosis.
Children's Discovery Institute of Washington University and St. Louis Children's Hospital, NIH/National Institute of Allergy and Infectious Diseases, March of Dimes

Contact: Julia Evangelou Strait
straitj@wustl.edu
314-286-0141
Washington University School of Medicine

Public Release: 24-Jul-2014
PLOS ONE
Researchers discover new way to determine cancer risk of chemicals
A new study has shown that it is possible to predict long-term cancer risk from a chemical exposure by measuring the short-term effects of that same exposure. The findings, which currently appear in the journal PLOS ONE, will make it possible to develop simpler and cheaper tests to screen chemicals for their potential cancer causing risk.
National Institutes of Health, Evans Center for Interdisciplinary Biomedical Research

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center

Public Release: 24-Jul-2014
Science
Atomic structure of key muscle component revealed in Penn study
Adding to the growing fundamental understanding of the machinery of muscle cells, a group of biophysicists from the Perelman School of Medicine at the University of Pennsylvania describe in the journal Science this week -- in minute detail -- how actin filaments are stabilized at one of their ends to form a basic muscle structure called the sarcomere.
NIH/National Institute of General Medical Sciences, US Department of Energy

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Public Release: 24-Jul-2014
Neuron
UCSF researchers uncover an unexpected role for endostatin in the nervous system
Researchers at UC San Francisco have discovered that endostatin, a protein that once aroused intense interest as a possible cancer treatment, plays a key role in the stable functioning of the nervous system.
National Institutes of Health

Contact: Jeffrey Norris
jeffrey.norris@ucsf.edu
415-502-6397
University of California - San Francisco

Public Release: 24-Jul-2014
PLOS ONE
Pesticide linked to 3 generations of disease
Washington State University researchers say ancestral exposures to the pesticide methoxychlor may lead to adult onset kidney disease, ovarian disease and obesity in future generations.
National Institutes of Health

Contact: Michael Skinner
skinner@wsu.edu
509-335-1524
Washington State University

Public Release: 24-Jul-2014
Cell
Mechanism found for development of protective HIV antibodies
Scientists at Duke Medicine have found an immunologic mechanism that makes broadly neutralizing antibodies in people who are HIV-1 infected.
NIH/National Institute of Allergy and Infectious Diseases, National Institutes of Health

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center

Public Release: 24-Jul-2014
Science
Jackson Laboratory researchers find new mechanism for neurodegeneration
A research team led by Jackson Laboratory professor and Howard Hughes investigator Susan Ackerman, Ph.D., have pinpointed a surprising mechanism behind neurodegeneration in mice, one that involves a defect in a key component of the cellular machinery that makes proteins, known as transfer RNA or tRNA.
NIH/National Cancer Institute, National Science Foundation

Contact: Joyce Peterson
joyce.peterson@jax.org
207-288-6058
Jackson Laboratory

Public Release: 24-Jul-2014
Child Development
Stronger early reading skills predict higher intelligence later
A study of 1,890 identical twins has found that strong early reading skill might positively affect later intelligence. The twins, who are part of an ongoing longitudinal study in the United Kingdom, share all their genes as well as a home environment. Differences shown in intellectual ability came from experiences they didn't share. The twin with stronger early reading skills was found to have higher overall intellectual ability by age 7.
UK Medical Research Council, NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development, European Research Council

Contact: Hannah Klein
hklein@srcd.org
202-289-0320
Society for Research in Child Development

Public Release: 24-Jul-2014
Child Development
Stress tied to change in children's gene expression related to emotion regulation, physical health
In a new study, researchers found that maltreatment affects the way children's genes are activated, which has implications for their long-term development and health. The researchers examined DNA methylation, a biomechanical mechanism that helps cells control which genes are turned on or off, in the blood of 56 children ages 11 to 14. Disruptions in this system affect emotional behavior, stress levels, and the immune system. These findings echo those of earlier studies of rodents.
NIH/National Institute of Mental Health, Waisman Center at the University of Wisconsin, NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development

Contact: Hannah Klein
hklein@srcd.org
202-289-0320
Society for Research in Child Development

Public Release: 24-Jul-2014
Neuron
Choice bias: A quirky byproduct of learning from reward
Many people value rewards they choose themselves more than rewards they merely receive, even when the rewards are actually equivalent. A new study in Neuron provides evidence that this long-observed quirk of behavior is a byproduct of how the brain reinforces learning from reward.
NIH/National Institute of Mental Health

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University

Public Release: 24-Jul-2014
PLOS Computational Biology
Gene changes in breast cancer cells pinpointed with new computational method
Computer scientists at Carnegie Mellon University, working with high-throughput data generated by breast cancer biologists at Lawrence Berkeley National Laboratory, have devised a computational method to determine how gene networks are rewired as normal breast cells turn malignant and as they respond to potential cancer therapy agents.
NIH/National Institute of General Medical Sciences, NIH/National Cancer Institute, DOE/Breast Cancer Research Program

Contact: Byron Spice
bspice@cs.cmu.edu
412-268-9068
Carnegie Mellon University

Public Release: 23-Jul-2014
Journal of Clinical Investigation
Researchers find mechanism that clears excess of protein linked with Type 2 diabetes
Researchers suggest that, in people who do not have Type 2 diabetes, autophagy prevents the accumulation of toxic forms of IAPP. In people with Type 2 diabetes, the process appears to not work properly, contributing to the destruction of beta cells. As the body's insulin producers, beta cells play a key role in maintaining healthy blood sugar levels.
NIH/National Institute of Diabetes and Digestive and Kidney Diseases,Larry L. Hillblom Foundation, Esther B. O'Keeffe Foundation

Contact: Enrique Rivero
erivero@mednet.ucla.edu
310-794-2273
University of California - Los Angeles Health Sciences

Public Release: 23-Jul-2014
Journal of Neuroscience
Study links autistic behaviors to enzyme
Biomedical scientists at the University of California, Riverside have published a study today that sheds light on the cause of autistic behaviors in Fragile X syndrome (FXS), the most common cause of autism. They found that an enzyme, MMP-9, plays a critical role. Working on mice, the researchers targeted MMP-9 as a potential therapeutic target in FXS and showed that genetic deletion of MMP-9 favorably impacts key aspects of FXS-associated anatomical and behaviors.
FRAXA Research Foundation, National Institutes of Health, California Institute for Regenerative Medicine

Contact: Iqbal Pittalwala
iqbal@ucr.edu
951-827-6050
University of California - Riverside

Public Release: 23-Jul-2014
The Journal of Neuroscience
Gene inhibitor, salmon fibrin restore function lost in spinal cord injury
A therapy combining salmon fibrin injections into the spinal cord and injections of a gene inhibitor into the brain restored voluntary motor function impaired by spinal cord injury, scientists at UC Irvine's Reeve-Irvine Research Center have found.
National Institutes of Health

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine

Showing releases 26-50 out of 3436.

<< < 1 | 2 | 3 | 4 | 5 | 6 > >>

     
   

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