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Department of Health and Human Services

News from the National Institutes of Health

Funded News

Key: Meeting M      Journal J      Funder F

Showing releases 251-275 out of 3759.

<< < 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 > >>

Public Release: 6-Aug-2015
Topical gel proves safe, effective treatment for patients with skin T cell lymphoma
Results of a phase one trial show that an investigational topical drug, resiquimod gel, causes regression of both treated and untreated tumor lesions and may completely remove cancerous cells from both sites in patients with early stage cutaneous T cell lymphoma (CTCL) -- a rare type of non-Hodgkin lymphoma that affects the skin. Currently, there is no cure for CTCL aside from a bone marrow transplant. However, the new study shows that the topical gel can eliminate malignant T cells, leading to diminished lesions.
National Institutes of Health, US Food and Drug Administration

Contact: Katie Delach
University of Pennsylvania School of Medicine

Public Release: 6-Aug-2015
LA BioMed researcher to examine why some patients ignore doctors' orders
Why do some patients ignore their doctors' orders on medication? A new study seeks answers and solutions to improve patients' health.
NIH/National Institute of Diabetes and Digestive and Kidney Diseases

Contact: Laura Mecoy
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)

Public Release: 6-Aug-2015
Current Biology
Fly model of motor neuron degeneration provides new avenues for exploration in humans
Researchers have developed a new model to study motor neuron degeneration and have used this to identify three genes involved in the neurodegeneration process. These findings could have relevance for understanding the progression of amyotrophic lateral sclerosis (ALS) and other forms of motor neuron disease. ALS is the most common form of adult-onset motor neuron disease and kills over 1,200 people a year in the UK.
Medical Research Council, Motor Neurone Disease Association, Max Rosenfeld Fund, King Trust Fellowship, National Institutes of Health, ALS Therapy Alliance

Contact: Louisa Wood
Babraham Institute

Public Release: 6-Aug-2015
Award-winning UMass Amherst mentor to lead new minority faculty support project
University of Massachusetts Amherst professor Sandra Petersen, recently honored at the White House for mentoring minority graduate students in the sciences, has received a $50,000 grant from the National Institutes of Health to lead a pilot mentoring network for minority faculty women in science, technology, engineering and mathematics at 15 Northeast institutions plus the Five Colleges.
National Institutes of Health, National Research Mentoring Network

Contact: Janet Lathrop
University of Massachusetts at Amherst

Public Release: 6-Aug-2015
Molecular Cell
Scientists discover how key proteins segregate vital genetic information during mitosis
Chromosomes are responsible for carrying our genes and essentially protecting the information that helps ensure normal growth, with vital instructions being passed on by mitosis. While this copying mechanism has been well understood for decades, scientists have been unable to describe exactly how genetic information is protected and properly segregated as mitosis is happening. New research from the Wistar Institute has identified an interaction between proteins that provides a pivotal role in organizing chromosomes so that vital genetic information gets passed on safely.
G. Harold & Leila Y. Mathers Charitable Foundation, National Institutes of Health

Contact: Ben Leach
The Wistar Institute

Public Release: 6-Aug-2015
UNC scientists pinpoint how a single genetic mutation causes autism
Last December, researchers identified more than 1,000 gene mutations in individuals with autism, but how these mutations increased risk for autism was unclear. Now, UNC School of Medicine researchers are the first to show how one of these mutations disables a molecular switch in one of these genes and causes autism.
National Institutes of Health, Angelman Syndrome Foundation, Foundation for Angelman Syndrome Therapeutics, Autism Speaks

Contact: Mark Derewicz
University of North Carolina Health Care

Public Release: 6-Aug-2015
Cell Reports
Rapid aging of the thymus linked to decline in free radical defenses
A critical immune organ called the thymus shrinks rapidly with age, putting older individuals at greater risk for life-threatening infections. A study published Aug. 6 in Cell Reports reveals that thymus atrophy may stem from a decline in its ability to protect against DNA damage from free radicals. The damage accelerates metabolic dysfunction in the organ, progressively reducing its production of pathogen-fighting T cells.
National Institutes of Health

Contact: Joseph Caputo
Cell Press

Public Release: 6-Aug-2015
Cell Stem Cell
Researchers identify drug candidate for skin, hair regeneration in scarred burn and trauma victims
Johns Hopkins researchers have identified a novel cell signaling pathway in mice through which mammals -- presumably including people -- can regenerate hair follicles and skin while healing from wounds.
NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases, Department of Defense's Armed Forces Institute of Regenerative Medicine; Northrup Grumman Electronic Systems, Alliance for Veterans Support Inc.

Contact: Taylor Graham
Johns Hopkins Medicine

Public Release: 5-Aug-2015
New England Journal of Medicine
Two-drug combination boosts survival in metastatic prostate cancer
Men with metastatic, hormone-sensitive prostate cancer gained more than a year of survival when they received both hormone-blocking medications and chemotherapy right after diagnosis, rather than delaying the chemo until the cancer worsened, according to a study led by Dana-Farber's Christopher Sweeney published in the New England Journal of Medicine.
Public Health Service Grants, NIH/National Cancer Institute, National Institutes of Health, and others

Contact: Teresa M Herbert
Dana-Farber Cancer Institute

Public Release: 5-Aug-2015
Cancer Discovery
Penn scientists identify key genetic factor that keeps moles from turning into melanoma
Moles are benign tumors found on the skin of almost every adult. Scientists have known for years that a mutation in the BRAF gene makes them start growing, but until now haven't understood why they stop. Now, researchers from the Perelman School of Medicine at the University of Pennsylvania have identified a major genetic factor that keeps moles in their usual non-cancerous, no-growth state.
National Institutes of Health, Melanoma Research Alliance, Dermatology Foundation, American Skin Association, Melanoma Research Foundation

Contact: Katie Delach
University of Pennsylvania School of Medicine

Public Release: 5-Aug-2015
Science Translational Medicine
Pitt team gets the beat, develops method of quantifying ciliary movement
Researchers at the University of Pittsburgh School of Medicine have figured out how to objectively quantify the beating action of cilia, the tiny, hair-like projections on cells that line nasal passages, the lungs and almost every other body tissue, according to a study published online today in Science Translational Medicine. Such digital signatures could help doctors more quickly and accurately diagnose ciliary motion defects.
National Institutes of Health, Pennsylvania Departmet of Health

Contact: Anita Srikameswaran
University of Pittsburgh Schools of the Health Sciences

Public Release: 5-Aug-2015
Proceedings of the National Academy of Sciences
Cancer treatment models get real
Rice University and MD Anderson Cancer Center researchers use a custom flow perfusion bioreactor to show the value of testing cancer samples in realistic environments.
MD Anderson Cancer Center, National Institutes of Health

Contact: David Ruth
Rice University

Public Release: 5-Aug-2015
American Journal of Clinical Nutrition
Consuming highly refined carbohydrates increases risk of depression
A diet high in refined carbohydrates may lead to an increased risk for new-onset depression in postmenopausal women, according to a study published in The American Journal of Clinical Nutrition.
National Institutes of Health

Contact: Lucky Tran
Columbia University Medical Center

Public Release: 5-Aug-2015
JAMA Surgery
Gastric bypass surgery lowers women's alcohol tolerance
Women who have gastric bypass surgery to lose weight should keep a close eye on their alcohol consumption, according to a study at Washington University School of Medicine in St. Louis. The researchers found that changes in how alcohol is metabolized after surgery can speed its delivery into the bloodstream, resulting in earlier and higher peaks in blood-alcohol levels.
NIH/National Institute on Alcohol Abuse and Alcoholism, NIH/National Institute of Diabetes and Digestive and Kidney Diseases, and NIH/National Center for Research Resources

Contact: Jim Dryden
Washington University School of Medicine

Public Release: 5-Aug-2015
Clinical Infectious Diseases
Viruses thrive in big families, in sickness and in health
A study led by the University of Utah School of Medicine finds that every child puts a household at increased risk for viral infections. Childless households had infections during three to four weeks of the year, while families with six children were infected for 45 weeks. But only half who tested positive reported feeling ill. Published in Clinical Infectious Diseases, the results can help families and health care providers know when illness should be cause for concern.
National Institutes of Health, HA and Edna Benning Presidential Endowment, Primary Children's Hospital Foundation, Pediatric Clinical and Translational Scholars Program, James S. McDonnell Foundation

Contact: Julie Kiefer
University of Utah Health Sciences

Public Release: 5-Aug-2015
Scientists solve structure of important protein for tumor growth
In a collaborative study between at Sanford Burnham Prebys Medical Discovery Institute and the Argonne National Laboratory, scientists have used a highly specialized X-ray crystallography technique to solve the protein structure of hypoxia-inducible factors, important regulators of a tumor's response to low oxygen.
National Institutes of Health

Contact: Patrick Bartosch
Sanford-Burnham Prebys Medical Discover Institute

Public Release: 5-Aug-2015
PLOS Genetics
Penn study details powerful molecular promoter of colon cancers
Cancer researchers already know of some oncogenes and other factors that promote the development of colon cancers, but they don't yet have the full picture of how these cancers originate and spread. Now researchers have illuminated another powerful factor in this process, by unraveling an additional pathway for the origin of colon cancer.
National Institutes of Health, The Lustgarten Family, The Hansen Foundation, and National Colon Cancer Research Alliance

Contact: Karen Kreeger
University of Pennsylvania School of Medicine

Public Release: 5-Aug-2015
Surveys reveal trends in global consumption of sugary beverages, fruit juices and milk
A team led by researchers from the Friedman School of Nutrition Science and Policy at Tufts University estimated global intakes of sugar-sweetened beverages, fruit juices, and milk across 187 countries. Variation was identified by age, sex and region, with implications for national and global nutrition policies.
NIH/National Institute of Diabetes and Digestive and Kidney Diseases, NIH/National Heart, Lung, and Blood Institute, Bill & Melinda Gates Foundation

Contact: Beverly Freeman
Tufts University, Health Sciences Campus

Public Release: 5-Aug-2015
Journal of Experimental Biology
Snow leopard blood no better prepared for high altitude than domestic cats
The blood of most cats is poorly equipped to carry oxygen at altitude, yet snow leopards are capable of scaling heights of over 6,000 meters. Is the oxygen carrying protein, hemoglobin, in their blood specially adapted to carry oxygen at altitude? Now an international team of scientists has discovered that snow leopard blood is no better at carrying oxygen at altitude than the blood of any other cat, preserving the mystery how snow leopards cope.
Danish Council for Independent Research, Carlsberg Foundation, National Institutes of Health

Contact: Kathryn Knight
The Company of Biologists

Public Release: 4-Aug-2015
$15 million funds research to help older adults prevent cognitive decline?
Researchers at Washington University School of Medicine in St. Louis, led by Eric J. Lenze, M.D., have received a $15 million grant to study strategies -- including exercise, health education, meditation and yoga -- aimed at helping older adults prevent or reverse typical age-related cognitive declines.
NIH/National Institute on Aging

Contact: Jim Dryden
Washington University School of Medicine

Public Release: 4-Aug-2015
Molecular Psychiatry
Team advances therapy preventing addiction relapse by erasing drug-associated memories
Scientists from the Florida campus of The Scripps Research Institute have made a discovery that brings them closer to a new therapy based on selectively erasing dangerous and tenacious drug-associated memories. A new study demonstrates the effectiveness of a single injection of an early drug candidate called blebbistatin in preventing relapse in animal models of methamphetamine addiction.
NIH/National Institute on Drug Abuse, NIH/National Institute for Neurological Disorders and Stroke, NIH/National Institute for Mental Health, Brain and Behavior Research Foundation

Contact: Eric Sauter
Scripps Research Institute

Public Release: 4-Aug-2015
Molecular Biology and Evolution
Researchers strategize to outsmart bacteria
Rice University scientists found a mechanism by which bacteria can become resistant to treatment with antibiotics. They hope to develop strategies to preserve the effectiveness of antibiotics.
US Army Edgewood Chemical Biological Center, NIH/National Institute of Allergy and Infectious Diseases, Defense Threat Reduction Agency

Contact: David Ruth
Rice University

Public Release: 4-Aug-2015
Journal of Interpersonal Violence
Opioid use and sexual violence among drug-using young adults in NYC
The research seeks to identify the potential role of drug use in increasing risk of sexual violence among young adult opioid users in NYC, and to identify the specific social and contextual factors surrounding this group's experiences of sexual violence.
NIH/National Institute on Drug Abuse

Contact: Christopher James
New York University

Public Release: 4-Aug-2015
Cell Metabolism
New discovery provides insight into the development of complications in type 1 diabetes
Joslin scientists have advanced understanding of how the cellular repair process is impaired in type 1 diabetes, which can cause cell death and lead to complications.
National Institutes of Health

Contact: Jeff Bright
Joslin Diabetes Center

Public Release: 4-Aug-2015
Journal of Alzheimer's Disease
Insulin's potential to treat dementia outlined in new study
The Journal of Alzheimer's Disease recently published online a study looking at the promising results of a $500,000 NIH study on the effects of intranasal insulin in improving Alzheimer's disease. It's a great story on the promise of scientific breakthroughs for this disease.
NIH/National Institute on Aging

Contact: Bobbi Nodell
University of Washington Health Sciences/UW Medicine

Showing releases 251-275 out of 3759.

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