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Department of Health and Human Services

News from the National Institutes of Health

Funded News

Key: Meeting M      Journal J      Funder F

Showing releases 251-275 out of 3717.

<< < 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 > >>

Public Release: 10-Sep-2015
Protein aggregation after heat shock is an organized, reversible cellular response
Protein aggregates that form after a cell is exposed to high, non-lethal temperatures appear to be part of an organized response to stress, and not the accumulation of damaged proteins en route to destruction. The findings shed new light on the biological nature of protein aggregates, which have been widely considered to be toxic dead-end products, but are increasingly being recognized as a new layer of cellular organization.
Alfred P. Sloan Foundation, National Institutes of Health, Pew Charitable Trusts

Contact: Kevin Jiang
University of Chicago Medical Center

Public Release: 10-Sep-2015
Stanford scientists produce cancer drug from rare plant in lab
Stanford scientists produced a common cancer drug -- previously only available from an endangered plant -- in a common laboratory plant. This work could lead to a more stable supply of the drug and allow scientists to manipulate that drug to make it even safer and more effective.
US National Institutes of Health

Contact: Amy Adams
Stanford University

Public Release: 10-Sep-2015
Telomerase can be successfully targeted by a highly specific inhibitor
New research from The Wistar Institute shows exactly how a known, highly selective small molecule telomerase inhibitor is able to bind with the enzyme, thus opening the possibility of developing more telomerase inhibitors that target this pocket of telomerase and could be clinically effective in a wide variety of cancer types.
NIH/National Institute of General Medical Sciences

Contact: Ben Leach
The Wistar Institute

Public Release: 9-Sep-2015
NYU researchers observe upward trend in hepatitis C infection rates among HIV+ MSM
Researchers at NYU have conducted a systematic review and meta-analysis of studies characterizing the incidence of the sexual transmission of HCV among HIV-positive MSM. The high reinfection rates and the attributable risk analysis suggest the existence of a subset of HIV-positive MSM with recurring sexual exposure to HCV. Approaches to HCV control in this population will need to consider the changing epidemiology of HCV infection in MSM.
National Institutes of Health

Contact: christopher james
New York University

Public Release: 9-Sep-2015
$10 million in federal grants to study botanicals for human health
The University of Illinois at Chicago College of Pharmacy has received a five-year, $9 million grant from the National Institutes of Health to continue its research into the safety and efficacy of botanical dietary supplements for women's health and another $1.2 million over five years to develop new chemical and biological approaches to the investigation of natural products.
NIH/Office of Dietary Supplements, NIH/National Center for Complementary and Integrative Health

Contact: Sam Hostettler
University of Illinois at Chicago

Public Release: 9-Sep-2015
NIH awards $2.8 million for study into new ways to detect and treat brain injury
Developing better treatments and an improved understanding of the biology behind brain injury from hemorrhagic strokes is the main goal of a three-year $2.8 million grant to the Translational Genomics Research Institute, Phoenix Children's Hospital, and Barrow Neurological Institute. Announced today, the funding comes from the National Institutes of Health's National Center for Advancing Translational Sciences (NCATS) under its Extracellular RNA (ExRNA) Communication program.
National Institutes of Health, National Center for Advancing Translational Sciences

Contact: Steve Yozwiak
The Translational Genomics Research Institute

Public Release: 9-Sep-2015
Journal of Neuroscience
External brain stimulation temporarily improves motor symptoms in people with Parkinson's
People with Parkinson's disease tend to slow down and decrease the intensity of their movements even though many retain the ability to move quickly and forcefully. Now, scientists report evidence that the slowdown likely arises from the brain's 'cost/benefit analysis,' which gets skewed by the loss of dopamine in people with PD. In addition, their small study demonstrated that noninvasive electrical stimulation of the brain corrected temporarily improved some patients' motor symptoms.
NIH/National Institute of Neurological Disorders and Stroke, Human Frontiers Science Program

Contact: Catherine Kolf
Johns Hopkins Medicine

Public Release: 9-Sep-2015
Study with 'never-smokers' sheds light on the earliest stages of nicotine dependence
In a study with 18 adults who had never smoked, scientists at Johns Hopkins report they have demonstrated one of the earliest steps in the process of addiction, and shown that some people are far more vulnerable to nicotine addiction than others. In a summary of the research, published online Sept. 8 in Psychopharmacology, the investigators say they have, for the first time, characterized the body's reaction to the first, tiniest 'hits' of nicotine.
NIH/National Institute on Drug Abuse

Contact: Shawna Williams
Johns Hopkins Medicine

Public Release: 9-Sep-2015
Journals of Gerontology: Medical Sciences
New study shows smoking doesn't always mean a shortened life span or cancer
Not all smokers experience early mortality, and a small proportion manage to survive to extreme ages. Using long-lived smokers as their phenotype, the authors of a study published today in The Journals of Gerontology, Series A: Biological Sciences & Medical Sciences identified a network of SNPs (a DNA sequence variation occurring commonly within a population) that allow certain individuals to better withstand environmental damage (like smoking) and mitigate damage. Collectively, these SNPs were strongly associated with high survival rates.
NIH/National Institute on Aging, Social Security Administration

Contact: Molly Grote
Oxford University Press USA

Public Release: 9-Sep-2015
$1.85 million NIH grant funds project to study virus interaction with the immune system and identify poxvirus
A $1.85 million National Institutes of Health grant is funding a research project that is looking at a family of viruses that have the potential to be the next smallpox as well as an effective weapon against cancer.
National Institutes of Health

Contact: Stefan Rothenburg
Kansas State University

Public Release: 9-Sep-2015
UMD receives $1.8 million grant to improve genomic data analysis tools
A University of Maryland genomics expert has been awarded a $1.8 million grant from the National Institutes of Health to expand the functionality of open source data visualization software that can help identify genomic markers for cancer and other diseases.
NIH/National Institute of General Medical Sciences

Contact: Tom Ventsias
University of Maryland

Public Release: 9-Sep-2015
New England Journal of Medicine
Penn team: Sustained remission of multiple myeloma after personalized cellular therapy
A multiple myeloma patient whose cancer had stopped responding after nine different treatment regimens experienced a complete remission after receiving an investigational personalized cellular therapy known as CTL019 developed by a team at the University of Pennsylvania. The investigational treatment was combined with chemotherapy and an autologous stem cell transplant -- a new strategy designed to target and kill the cells that give rise to myeloma cells.
Novartis, National Institutes of Health, Conquer Cancer Foundation

Contact: Holly Auer
University of Pennsylvania School of Medicine

Public Release: 9-Sep-2015
Science Translational Medicine
Study IDs viral protein that causes dengue shock
UC Berkeley scientists have identified a viral protein secreted by cells infected with the dengue virus as a key culprit behind the fluid loss and resulting shock that are the hallmark of severe -- and potentially fatal -- infections.
NIH/National Institute of Allergy and Infectious Diseases

Contact: Sarah Yang
University of California - Berkeley

Public Release: 9-Sep-2015
JAMA Surgery
Postoperative delirium results in poor outcomes in older adults
Researchers from the Aging Brain Center at the Institute for Aging Research at Hebrew SeniorLife confirm that delirium is a significant and independent contributing factor to poor postsurgical outcomes in older adults. Findings published in JAMA Surgery suggest that the combination of major postoperative complications and delirium demonstrate a strong combined effect on adverse outcomes in older adults undergoing major surgery.
NIH/National Institute on Aging, HRSA Training Grant, John A. Hartford Foundation

Contact: Dawn Peters
Hebrew SeniorLife Institute for Aging Research

Public Release: 9-Sep-2015
A hint of increased brain tumor risk -- 5 years before diagnosis
A new study suggests that changes in immune function can occur as long as five years before the diagnosis of a brain tumor that typically produces symptoms only three months before it is detected.
NIH/National Cancer Institute, National Institutes of Health, Ohio State University Comprehensive Cancer Center

Contact: Judith Schwartzbaum
Ohio State University

Public Release: 8-Sep-2015
Childhood cancer research at UCSF to transcend tissue types with innovative grant
Researchers at UC San Francisco are leading a five-year, $10 million research project dedicated to pediatric cancer, funded by the first grant of its kind to focus on a molecular pathway that underlies many cancers rather than on a cancer in a particular organ or tissue in the body.
NIH/National Cancer Institute

Contact: Pete Farley
University of California - San Francisco

Public Release: 8-Sep-2015
CHORI's Dr. Ronald Krauss receives $13.18 million NIH precision medicine grant
Children's Hospital Oakland Research Institute Senior Scientist Dr. Ronald Krauss has received a five-year, $13.18 million grant from the NIH for precision medicine research in statin response. The grant will enable Dr. Krauss to apply a multidisciplinary approach to identify genetic determinants of the efficacy of statin drugs in reducing the risk of cardiovascular disease (CVD), as well as the risk for adverse effects of statins, specifically myopathy and type 2 diabetes.
National Institutes of Health

Contact: Melinda Krigel
Children's Hospital & Research Center Oakland

Public Release: 8-Sep-2015
Diabetes drug boosts bone fat and fracture risk; exercise can partially offset the effect
Inside our bones there is fat. Diabetes increases the amount of this marrow fat. And now a study from the UNC School of Medicine shows how some diabetes drugs substantially increase bone fat and thus the risk of bone fractures.
National Institutes of Health

Contact: Mark Derewicz
University of North Carolina Health Care

Public Release: 8-Sep-2015
American Naturalist
Parasitic disease: Contact rates, competition matter in transmission
Contact and competition among different animals within a community matters when it comes to the possibility of parasitic disease outbreak, according to new research from the National Institute for Mathematical and Biological Synthesis and the University of Georgia, Athens.
NIH/National Institute for Mathematical and Biological Synthesis

Contact: Catherine Crawley
National Institute for Mathematical and Biological Synthesis (NIMBioS)

Public Release: 8-Sep-2015
Journal of Physiology
Researchers identify mechanism that impairs blood flow with aging
With the world's elderly population expected to double by 2050, understanding how aging affects the body is an important focus for researchers globally. Cardiovascular disease, the No. 1 cause of death worldwide, often is associated with aging arteries that restrict blood flow. Now, University of Missouri researchers have identified an age-related cause of arterial dysfunction, a finding that could lead to future treatments for some forms of vascular disease.
National Institutes of Health

Contact: Jeffrey Hoelscher
University of Missouri-Columbia

Public Release: 8-Sep-2015
Drugs behave as predicted in computer model of key protein, enabling cancer drug discovery
Drugs behaved as predicted in a computer-generated model of the key protein, P-glycoprotein, say researchers at Southern Methodist University, Dallas. The model allows pharmacological researchers to dock nearly any drug and see how it behaves in P-gp, a cellular protein linked to failure of chemotherapy. A dynamic mechanism that overcomes reliance on static images of P-gp's structure, the new model provides hope for finding drug-like compounds that inhibit P-gp from pumping out chemotherapeutic drugs.
National Institutes of Health, NIH/National Institute of General Medical Sciences, Communities Foundation of Texas, SMU University Research Council, SMU Dedman College Dean's Research Council, SMU Dedman College Center for Drug Discovery

Contact: Margaret Allen
Southern Methodist University

Public Release: 8-Sep-2015
Trends in Cognitive Sciences
UW researchers are pioneering research on 'body maps' in babies' brains
Body maps, which show how certain parts of the brain correspond to the body's topography, have been studied extensively in adult humans and other primates. But University of Washington researchers are among the first scientists worldwide to study body maps in infants, which can provide crucial information about how babies develop a sense of their physical selves and their earliest social relationships.
National Science Foundation, National Institutes of Health

Contact: Deborah Bach
University of Washington

Public Release: 8-Sep-2015
Proceedings of the National Academy of Sciences
Genome mining effort discovers 19 new natural products in 4 years
It took a small group of researchers only four years -- a blink of an eye in pharmaceutical terms -- to scour a collection of 10,000 bacterial strains and isolate the genes responsible for making 19 unique, previously unknown phosphonate natural products, researchers report. Each of these products is a potential new drug. One of them has already been identified as an antibiotic.
NIH/National Institute of General Medical Services

Contact: Diana Yates
University of Illinois at Urbana-Champaign

Public Release: 8-Sep-2015
Molecular Psychiatry
Stem cell-derived 'mini-brains' reveal potential drug treatment for rare disorder
Using 'mini-brains' built with induced pluripotent stem cells derived from patients with a rare, but devastating, neurological disorder, researchers at University of California, San Diego School of Medicine say they have identified a drug candidate that appears to 'rescue' dysfunctional cells by suppressing a critical genetic alteration.
California Institute for Regenerative Medicine, National Institutes of Health, International Rett Syndrome Foundation, NARSAD, NIH/National Institute of Neurological Disorders and Stroke, Fonds voor Wetenschappelijk Onderzoek, and others

Contact: Scott LaFee
University of California - San Diego

Public Release: 8-Sep-2015
Pharmacology Research & Perspectives
New drug-like compounds may improve odds of men battling prostate cancer, researchers find
Researchers at Southern Methodist University, Dallas, have discovered new drug-like compounds that could ultimately be developed into medicines that offer better odds of survival to prostate cancer patients. The new compounds target the human protein P-gp, which causes resistance against a majority of the drugs currently available for treating cancer and HIV/AIDS. The new compounds, discovered via computer-generated models, are good candidates for development into drugs since the compounds have low toxicity to noncancerous cells.
National Institutes of Health, NIH/National Institute of General Medical Sciences, Communities Foundation of Texas, Southern Methodist University

Contact: Margaret Allen
Southern Methodist University

Showing releases 251-275 out of 3717.

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