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Department of Health and Human Services

News from the National Institutes of Health

Funded News


Key: Meeting M      Journal J      Funder F

Showing releases 276-300 out of 3799.

<< < 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 > >>

Public Release: 7-Jul-2015
The BMJ
Serious adverse events rare in healthy volunteers participating in Phase I drug trials
Many people believe that Phase I trials with healthy volunteers are very risky and because they pose risks with no benefits, unethical. But how risky are such trials? Less than 1 percent of 11,000 healthy volunteers who participated in 394 Phase I trials for new drugs experienced serious complications, according to a new meta-analysis of participants in non-cancer, Phase I medication trials. In addition, none of the volunteers died or suffered persistent disabilities linked to the experimental drugs.
National Institutes of Health, University of Pennsylvania

Contact: Anna Duerr
anna.duerr@uphs.upenn.edu
215-796-4829
University of Pennsylvania School of Medicine

Public Release: 7-Jul-2015
JAMA
Memory and thinking ability keep getting worse for years after a stroke, new study finds
A stroke happens in an instant. And many who survive one report that their brain never works like it once did. But new research shows that these problems with memory and thinking ability keep getting worse for years afterward -- and happen faster than normal brain aging.
NIH/National Institute for Neurological Disorders and Stroke, NIH/National Institute on Aging

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 7-Jul-2015
Environmental Health Perspectives
Research encourages the consideration of air pollution when planning housing near transit
Policymakers and developers lack a complete picture of the potential dangers of air pollution when advocating the construction of high-density housing (like apartment buildings) along traffic corridors to take advantage of public transit.
National Institutes of Health, US Environmental Protection Agency, Hastings Foundation

Contact: Robert Perkins
perkinsr@usc.edu
213-220-0017
University of Southern California

Public Release: 7-Jul-2015
Proceedings of the National Academy of Sciences
Sculpting a cell's backside
When Greek mythology and cell biology meet, you get the protein Callipygian, recently discovered and named by researchers at The Johns Hopkins University for its role in determining which area of a cell becomes the back as it begins to move.
NIH/National Institute of General Medical Sciences, American Heart Association

Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine

Public Release: 7-Jul-2015
Nature Communications
Organ transplant rejection may not be permanent
Rejection of transplanted organs in hosts that were previously tolerant may not be permanent, report scientists from the University of Chicago. Using a mouse model of cardiac transplantation, they found that immune tolerance can spontaneously recover after an infection-triggered rejection event, and that hosts can accept subsequent transplants as soon as a week after. This process depends on regulatory T-cells, a component of the immune system that acts as a 'brake' for other immune cells.
NIH/National Institute of Allergy and Infectious Diseases

Contact: Kevin Jiang
kevin.jiang@uchospitals.edu
773-795-5227
University of Chicago Medical Center

Public Release: 6-Jul-2015
Brain
Enriched blood cells preserve cognition in mice with features of Alzheimer's disease
Cedars-Sinai researchers have successfully tested two new methods for preserving cognition in laboratory mice that exhibit features of Alzheimer's disease by using white blood cells from bone marrow and a drug for multiple sclerosis to control immune response in the brain.
Coins for Alzheimer's Research Trust Fund, BrightFocus Foundation, Maurice Marciano Family Foundation, Saban Family Foundation, NIH/National Center for Advancing Translational Sciences

Contact: Sandy Van
sandy@prpacific.com
808-526-1708
Cedars-Sinai Medical Center

Public Release: 6-Jul-2015
Proceedings of the National Academy of Sciences
UC Davis researchers find key mechanism that causes neuropathic pain
A biological process called endoplasmic reticulum stress appears to play a key role in causing neuropathic pain, according to this new study. The discovery could eventually lead to new therapeutics for controlling chronic pain associated with trauma, diabetes, shingles, multiple sclerosis or other conditions that cause nerve damage.
NIH/National Institute of Environmental Health Sciences, NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases

Contact: Patricia Bailey
pjbailey@ucdavis.edu
530-752-9843
University of California - Davis

Public Release: 6-Jul-2015
PLOS ONE
UNC researchers find 2 biomarkers linked to severe heart disease
Researchers at the UNC School of Medicine created a first-of-its-kind animal model to pinpoint two biomarkers that are elevated in the most severe form of coronary disease.
National Institutes of Health, North Carolina Biotechnology Center

Contact: Mark Derewicz
mark.derewicz@unch.unc.edu
919-923-0959
University of North Carolina Health Care

Public Release: 6-Jul-2015
Proceedings of the National Academy of Sciences
Heart attack treatment hypothesis 'busted'
Researchers have long had reason to hope that blocking the flow of calcium into the mitochondria of heart and brain cells could be one way to prevent damage caused by heart attacks and strokes. But in a study of mice engineered to lack a key calcium channel in their heart cells, Johns Hopkins scientists appear to have cast a shadow of doubt on that theory. A report on their study is published online this week in Proceedings of the National Academy of Sciences.
NIH/National Heart, Lung, and Blood Institute, NIH/National Institute of General Medical Sciences, National Center for Research Resources, NIH/National Institute of Diabetes and Digestive and Kidney Diseases, Veterans Administration, and others

Contact: Lauren Nelson
laurennelson@jhmi.edu
410-955-8725
Johns Hopkins Medicine

Public Release: 6-Jul-2015
Science
Study explains how dengue virus adapts as it travels, increasing chances for outbreaks
A researcher from The University of Texas Medical Branch at Galveston is an integral member of a collaborative group that is the first to explain the mechanisms that the Dengue virus has developed to optimize its ability to cause outbreaks as it travels across the globe to new places and revisits old ones.
The Singapore National Medical Research Council, Ministry of Health in Singapore, Institute of Molecular and Cell Biology, Agency of Science, Technology and Research in Singapore, National Institutes of Health

Contact: Donna Ramirez
donna.ramirez@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston

Public Release: 6-Jul-2015
Neurophotonics
Reducing stroke damage may be next for OCT technology widely used in vision healthcare
A new article by University of Washington researchers in the journal Neurophotonics, published by SPIE, the international society for optics and photonics, reports on use of optical coherence tomography to obtain high-resolution images showing blood-flow dynamics in the brain before, during, and after stroke-like states. The information may ultimately enable clinicians to reduce stroke damage.
National Institutes of Health

Contact: Amy Nelson
amy@spie.org
360-685-5478
SPIE--International Society for Optics and Photonics

Public Release: 6-Jul-2015
Psychology of Addictive Behaviors
Adolescents who view medical marijuana ads more likely to use the drug, study finds
A new study raises questions about whether there is a need to revise prevention programming for youth as the availability, visibility and legal status of marijuana changes. The report found that adolescents who saw advertising for medical marijuana were more likely to either report using marijuana or say they planned to use the substance in the future.
NIH/National Institute of Alcohol Abuse and Alcoholism

Contact: Warren Robak
robak@rand.org
310-451-6913
RAND Corporation

Public Release: 6-Jul-2015
Evolution
Blacklegged tick populations have expanded via migration, Penn biologists show
In a new study, biologists from the University of Pennsylvania used genetic and phylogeographic analyses to determine the origin and recent migratory history of newly discovered tick populations in the Northeastern United States. Their findings indicate that the ticks moved into new areas from established populations, mainly through short-distance, local moves.
National Institutes of Health, Burroughs Wellcome Fund

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania

Public Release: 6-Jul-2015
Immunity
Temple-led research team finds bacterial biofilms may play a role in lupus
Lupus, multiple sclerosis, and type-1 diabetes are among more than a score of diseases in which the immune system attacks the body. But why the immune system begins its misdirected assault has remained a mystery. Now, researchers at Temple University School of Medicine have shown that bacterial communities known as biofilm play a role in the development of the autoimmune disease systemic lupus erythematosus -- a discovery that may provide important clues about several autoimmune ailments.
National Institutes of Health, NIH/National Institutes of Allergy and Infectious Diseases, Fox Chase Cancer Center-Temple University Nodal Grant, Lupus Research Institute Innovation Research Grant, Lupus Foundation's Goldie Simon Preceptorship Award, etc.

Contact: Jeremy Walter
Jeremy.Walter@tuhs.temple.edu
267-838-0398
Temple University Health System

Public Release: 6-Jul-2015
Nature Communications
How to rule a gene galaxy: A lesson from developing neurons
A new study published in Nature Communications by researchers from the MRC Centre for Developmental Neurobiology at IoPPN, carried out in collaboration with the Tian lab at the Rutgers New Jersey Medical School, found that many RNA messengers encoding neuronal proteins contain specialized sequences that can promote their destabilization in the presence of an RNA-binding protein called tristetraprolin, or TTP.
Biotechnology and Biosciences Research Council, National Institutes of Health, National Medical Research Council

Contact: Andreia Carvalho
andreia.carvalho@kcl.ac.uk
44-207-848-6804
King's College London

Public Release: 6-Jul-2015
Journal of Biological Chemistry
Ion channel mechanics yield insights into optogenetics experiments
Optogenetics techniques, which allow scientists to map and control nerve cells using light stimulation, are being used to study neural circuits in the brain with unprecedented precision. This revolutionary technology relies on light-sensitive proteins such as channelrhodopsins, and researchers at UC Santa Cruz have now determined the molecular mechanism involved in the light-induced activation of one of these proteins.
National Institutes of Health

Contact: Tim Stephens
stephens@ucsc.edu
831-459-4352
University of California - Santa Cruz

Public Release: 6-Jul-2015
Cutting big data down to a usable size
Next-generation DNA sequencing technologies have turned the vision of precision medicine into a plausible reality, but also threaten to overwhelm computing infrastructures with unprecedented volumes of data. A recent $1.3 million award from the National Institutes of Health will allow researchers at the University of Illinois and Stanford to help address this challenge by developing novel data compression strategies.
National Institutes of Health, National Institutes of Health Big Data to Knowledge Initiative

Contact: Nicholas Vasi
nvasi@illinois.edu
Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign

Public Release: 6-Jul-2015
Nature Medicine
Fundamental beliefs about atherosclerosis overturned
Doctors' efforts to battle the dangerous atherosclerotic plaques that build up in our arteries and cause heart attacks and strokes are built on several false beliefs about the fundamental composition and formation of the plaques, new research from the University of Virginia School of Medicine shows. These new discoveries will force researchers to reassess their approaches to developing treatments and discard some of their basic assumptions about atherosclerosis, commonly known as hardening of the arteries.
National Institutes of Health, American Heart Association

Contact: Josh Barney
jdb9a@virginia.edu
434-906-8864
University of Virginia Health System

Public Release: 6-Jul-2015
Nature Medicine
Age-related cognitive decline tied to immune-system molecule
Researchers at UC San Francisco and Stanford School of Medicine have shown that a blood-borne molecule that increases in abundance as we age blocks regeneration of brain cells and promotes cognitive decline.
California Institute for Regenerative Medicine, National Science Foundation, US Department of Veterans Affairs, NIH/National Institute on Aging, Sandler Foundation, Marc and Lynne Benioff, UCSF Clinical and Translational Science Institute

Contact: Pete Farley
peter.farley@ucsf.edu
415-502-4608
University of California - San Francisco

Public Release: 6-Jul-2015
Proceedings of the National Academy of Sciences
Why don't men live as long as women?
Across the entire world, women can expect to live longer than men. But why does this occur, and was this always the case? A new USC-led study reveals that vulnerability to heart disease is the biggest culprit behind a surge in higher death rates for men versus women during the 20th century.
NIH/National Institute on Aging

Contact: Beth Newcomb
bethdunh@usc.edu
213-740-0821
University of Southern California

Public Release: 6-Jul-2015
Proceedings of the National Academy of Sciences
Brain imaging shows how children inherit their parents' anxiety
A study in an extended family of monkeys provides important insights into how the risk of developing anxiety and depression is passed from parents to children. The study from the Department of Psychiatry and the Health Emotions Research Institute at the University of Wisconsin-Madison shows how an over-active brain circuit involving three brain areas inherited from generation to generation may set the stage for developing anxiety and depressive disorders.
NIH/National Institute of Mental Health

Contact: Susan Lampert Smith
Ssmith5@uwhealth.org
608-890-5643
University of Wisconsin-Madison

Public Release: 6-Jul-2015
Nature Structural & Molecular Biology
Protein suggests a new strategy to thwart infection
The newfound ability of a protein of the intestines and lungs to distinguish between human cells and the cells of bacterial invaders could underpin new strategies to fight infections. Writing this week in the journal Nature Structural and Molecular Biology, a team led by University of Wisconsin-Madison Professor Laura Kiessling describes the knack of a human protein known as intelectin to distinguish between our cells and those of the disease-causing microbes that invade our bodies.
National Institutes of Health

Contact: Laura Kiessling
kiessling@chem.wisc.edu
608-262-0541
University of Wisconsin-Madison

Public Release: 6-Jul-2015
Journal of the American College of Cardiology
Extra heartbeats could be modifiable risk factor for congestive heart failure
Common extra heartbeats known as premature ventricular contractions may be a modifiable risk factor for congestive heart failure and death, according to researchers at UC San Francisco.
American Heart Association, Joseph Drown Foundation, NIH/National Heart, Lung, Blood Institute, NIH/National Institute of Neurological Disorders and Stroke, NIH/National Institute on Aging

Contact: Scott Maier
scott.maier@ucsf.edu
415-502-6397
University of California - San Francisco

Public Release: 6-Jul-2015
Annals of Internal Medicine
Typically disregarded brain lesions may warn of heightened stroke risk
Scientists with the University of Mississippi Medical Center and colleagues found that very small brain lesions noted on brain imaging that would typically be disregarded by clinicians are associated with a heightened risk of stroke and death. The discovery about these tiny lesions -- areas of the brain where tissue may have been damaged by injury or disease -- may help physicians identify people at risk of stroke and death as early as middle age.
NIH/National Heart Lung and Blood Institute

Contact: Dustin Barnes
dlbarnes@umc.edu
601-984-1970
University of Mississippi Medical Center

Public Release: 6-Jul-2015
Proceedings of the National Academy of Sciences
Researchers learn to measure aging process in young adults
A research team from the US, UK, Israel and New Zealand has identified multiple health factors that may be combined to determine whether people are aging faster or slower than their peers. They determined both a biological age and a pace of aging for study participants from age 26 to 38.
New Zealand Health Research Council, NIH/National Institute on Aging, Medical Research Council, Jacobs Foundation, Yad Hanadiv Rothschild Foundation

Contact: Karl Leif Bates
karl.bates@duke.edu
919-681-8054
Duke University

Showing releases 276-300 out of 3799.

<< < 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 > >>

     
   

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