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Key: Meeting M      Journal J      Funder F

Showing releases 2876-2900 out of 3690.

<< < 111 | 112 | 113 | 114 | 115 | 116 | 117 | 118 | 119 | 120 > >>

Public Release: 4-Jan-2015
Journal of Nutrition
Fructose more toxic than table sugar in mice
When University of Utah biologists fed mice sugar in doses proportional to what many people eat, the fructose-glucose mixture found in high-fructose corn syrup was more toxic than sucrose or table sugar, reducing both the reproduction and lifespan of female rodents.
National Institutes of Health, National Science Foundation.

Contact: Lee J. Siegel
University of Utah

Public Release: 2-Jan-2015
Proceedings of the National Academy of Sciences
HIV vaccines should avoid viral target cells, primate model study suggests
Vaccines designed to protect against HIV have backfired in clinical trials. Non-human primate model studies suggest an explanation.
NIH/National Institute of Allergy and Infectious Diseases

Contact: Lisa Newbern
Emory Health Sciences

Public Release: 2-Jan-2015
Proceedings of the National Academy of Sciences
Predicting superbugs' countermoves to new drugs
With drug-resistant bacteria on the rise, even common infections that were easily controlled for decades are proving trickier to treat with standard antibiotics. New drugs are desperately needed, but so are ways to maximize the effective lifespan of these drugs. To accomplish that, Duke University researchers used software they developed to predict a constantly-evolving infectious bacterium's counter-moves to one of these new drugs ahead of time, before the drug is even tested on patients.
National Institutes of Health, US Department of Energy

Contact: Robin Ann Smith
Duke University

Public Release: 2-Jan-2015
Journal of Clinical Investigation
Not all obese people develop metabolic problems linked to excess weight
Obesity does not always go hand in hand with metabolic changes in the body that can lead to diabetes, heart disease and stroke, according to new research at Washington University School of Medicine in St. Louis.
NIH/National Institute of Diabetes and Digestive and Kidney Diseases, NIH/National Center for Research Resources, Longer Life Foundation, Kilo Foundation

Contact: Jim Dryden
Washington University School of Medicine

Public Release: 1-Jan-2015
'Bad luck' of random mutations plays predominant role in cancer, study shows
Scientists from the Johns Hopkins Kimmel Cancer Center have created a statistical model that measures the proportion of cancer incidence, across many tissue types, caused mainly by random mutations that occur when stem cells divide. By their measure, two-thirds of adult cancer incidence across tissues can be explained primarily by 'bad luck,' when these random mutations occur in genes that can drive cancer growth, while the remaining third are due to environmental factors and inherited genes.
Virginia and D. K. Ludwig Fund for Cancer Research, Lustgarten Foundation for Pancreatic Cancer Research, Sol Goldman Pancreatic Cancer Research Center, NIH/National Cancer Institute

Contact: Vanessa Wasta
Johns Hopkins Medicine

Public Release: 1-Jan-2015
Fat isn't all bad: Skin adipocytes help protect against infections
When it comes to skin infections, a healthy and robust immune response may depend greatly upon what lies beneath. In a new paper published in the Jan. 2, 2015 issue of Science, researchers at the University of California, San Diego School of Medicine report the surprising discovery that fat cells below the skin help protect us from bacteria.
National Institutes of Health, The Atopic Dermatitis Research Network, The Edward Mallinckrodt Jr. Foundation, The Dermatology Foundation

Contact: Scott LaFee
University of California - San Diego

Public Release: 1-Jan-2015
Findings point to potential approach to treat virus causing illness, possible paralysis
New research findings point toward a class of compounds that could be effective in combating infections caused by enterovirus D68, which has stricken children with serious respiratory infections and might be associated with polio-like symptoms in the United States and elsewhere.
National Institutes of Health

Contact: Emil Venere
Purdue University

Public Release: 1-Jan-2015
Defying textbook science, study finds new role for proteins
Results from a study published on Jan. 1 in Science defy textbook science, showing for the first time that the building blocks of a protein, called amino acids, can be assembled without blueprints -- DNA and an intermediate template called messenger RNA. A team of researchers has observed a case in which another protein specifies which amino acids are added.
Searle Scholars Program, Howard Hughes Medical Institute, National Institutes of Health

Contact: Julie Kiefer
University of Utah Health Sciences

Public Release: 31-Dec-2014
New England Journal of Medicine
Mayo Clinic: Women with atypical hyperplasia are at higher risk of breast cancer
Women with atypical hyperplasia of the breast have a higher risk of developing breast cancer than previously thought, a Mayo Clinic study has found. Results of the study appear in a special report on breast cancer in the New England Journal of Medicine.
National Institutes of Health

Contact: Joe Dangor
Mayo Clinic

Public Release: 31-Dec-2014
Molecular Cell
Penn scientists identify patterns of RNA regulation in the nuclei of plants
In a new study done in plants, University of Pennsylvania biologists give a global view of the patterns that can affect the various RNA regulatory processes that occur before these molecules move into the cytoplasm, where they are translated into the proteins that make up a living organism.
National Science Foundation, NIH/National Institute of General Medical Sciences

Contact: Katherine Unger Baillie
University of Pennsylvania

Public Release: 31-Dec-2014
3-D culture system for pancreatic cancer has potential to change therapeutic approaches
Pancreatic cancer is one of the most deadly forms of cancer, with only 6 percent of patients surviving five years after diagnosis. Today, CSHL and The Lustgarten Foundation announce the development of a new model system to grow both normal and cancerous pancreatic cells in the laboratory. Their work promises to change the way pancreatic cancer research is done, allowing scientists to interrogate the pathways driving this devastating disease while searching for new drug targets.
Lustgarten Foundation for Pancreatic Cancer Research, Cold Spring Harbor Laboratory Association, NIH/National Cancer Institute Center for Cancer Genomics, Carcinoid Foundation, PCUK, David Rubinstein Center for Pancreatic Cancer Research

Contact: Jaclyn Jansen
Cold Spring Harbor Laboratory

Public Release: 30-Dec-2014
Medicine & Science in Sports & Exercise
Researchers find significant link to daily physical activity, vascular health
As millions of Americans resolve to live healthier lives in 2015, research from the University of Missouri School of Medicine shows just how important diligent daily physical activity is. The researchers found that reducing daily physical activity for even a few days leads to decreases in the function of the inner lining of blood vessels in the legs of young, healthy subjects causing vascular dysfunction that can have prolonged effects.
National Institutes of Health, American College of Sports Medicine, American Heart Association Pre-Doctoral Fellowship

Contact: Stephanie Baehman
University of Missouri-Columbia

Public Release: 30-Dec-2014
Proceedings of the National Academy of Sciences
Molecules seen binding to HIV-1's protective capsule, blocking infection
New research shows an HIV-1 inhibitor and a host protein binding to HIV-1's protective capsule, preventing it from disassembling. Viral genetic information is kept inside. Dr. Dmitri Ivanov of The University of Texas Health Science Center at San Antonio and his collaborators believe the process can be targeted for therapeutic purposes in HIV-1 infections.
National Institutes of Health

Contact: Will Sansom
University of Texas Health Science Center at San Antonio

Public Release: 30-Dec-2014
Proceedings of the National Academy of Sciences
Cancer treatment potential discovered in gene repair mechanism
Case Western Reserve researchers have identified a two-pronged therapeutic approach that shows great potential for weakening and then defeating cancer cells. The team's complex mix of genetic and biochemical experiments unearthed a way to increase the presence of a tumor-suppressing protein which, in turn, gives it the strength to direct cancer cells toward a path that leads to their destruction. The breakthrough detailed appeared in the Nov. 24 online edition of the journal PNAS.
National Institutes of Health, National Center for Advancing Translational Sciences, Clinical and Translational Collaborative of Cleveland

Contact: Jeannette Spalding
Case Western Reserve University

Public Release: 30-Dec-2014
New liver cancer target is a protein that accelerates inflammation
Hepatitis, alcohol consumption, and even obesity can produce chronic inflammation in the liver and set the stage for cancer. A $1.6 million National Cancer Institute grant will help scientists to determine what enables the deadly transformation and block it. They have their sights on the protein, TREM-1, which accelerates inflammation.
NIH/National Cancer Institute

Contact: Toni Baker
Medical College of Georgia at Georgia Regents University

Public Release: 30-Dec-2014
Antimicrobial Agents and Chemotherapy
New treatment strategy allows lower doses of toxic tuberculosis drug without compromising potency
While an effective treatment is available for combating multidrug-resistant tuberculosis, it carries serious side effects for patients. New research conducted at the Center for Tuberculosis Research at the Johns Hopkins University School of Medicine shows that lower doses of the toxic drug bedaquiline -- given together with verapamil, a medication that's used to treat various heart conditions -- can lead to the same antibacterial effects as higher toxic doses of bedaquiline.
NIH/National Institute of Allergy and Infectious Diseases

Contact: Lauren Nelson
Johns Hopkins Medicine

Public Release: 30-Dec-2014
PLOS Medicine
Neonatal HBV vaccine reduces liver cancer risk
Neonatal HBV vaccination reduces the risk of liver cancer and other liver diseases in young adults in China, according to a study published by Chunfeng Qu, Taoyang Chen, Yawei Zhang and colleagues from the Cancer Institute & Hospital at the Chinese Academy of Medical Sciences, Qidong Liver Cancer Institute, China, and Yale School of Public Health and School of Medicine, USA in this week's PLOS Medicine.
State Key Projects Specialized on Infection Diseases, 973 Program Project of China, National Institutes of Health, 6th to 11th Key Technologies R&D Program of China

Contact: Maya Sandler

Public Release: 29-Dec-2014
Proceedings of the National Academy of Sciences
Tracing evolution of chicken flu virus yields insight into origins of deadly H7N9 strain
An international research team has shown how changes in a flu virus that has plagued Chinese poultry farms for decades helped create the novel avian H7N9 influenza A virus that has sickened more than 375 people since 2013. The research appears in the current online early edition of the scientific journal Proceedings of the National Academy of Sciences.
National Natural Science Foundation of China, National Basic Research Program, China Scholarship Foundation, Key Technologies Research & Development Program of China, China Agriculture Research System, NIH/National Institute of Allergy and Infectious Dise

Contact: Carrie Strehlau
St. Jude Children's Research Hospital

Public Release: 29-Dec-2014
Team finds mechanism of toxin's inflammatory effect on lungs
University of Texas Health Science Center at San Antonio and Washington State University researchers documented a never-before-seen mechanism by which a bacterial toxin leads to severe inflammation in asthma and other acute and chronic pulmonary diseases.
NIH/National Institute of Allergy and Infectious Diseases, Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation

Contact: Will Sansom
University of Texas Health Science Center at San Antonio

Public Release: 29-Dec-2014
Cancer Discovery
Cancer-causing mutation discovered in 1982 finally target of clinical trials
A recent article in the journal Cancer Discovery describes clinical trials at the University of Colorado Cancer Center and elsewhere that match drugs to long-overlooked oncogene, TRK, offering targeted treatment options for cancers that harbor these gene abnormalities.
V Foundation, National Institutes of Health, National Cancer Institute

Contact: Garth Sundem
University of Colorado Anschutz Medical Campus

Public Release: 29-Dec-2014
Stem Cells
Reprogramming stem cells may prevent cancer after radiation
University of Colorado Cancer Center study published today in Stem Cells shows that pre-programmed stem cell death allows cancer to grow after full-body irradiation, and that NOTCH signaling may restore stem cell function, protecting against cancer after radiation.
National Institutes of Health, Leukemia and Lymphoma Society

Contact: Garth Sundem
University of Colorado Anschutz Medical Campus

Public Release: 29-Dec-2014
Clinical Intervensions in Aging
Patient self-reporting version of 'blood pressure cuff' for dementia is reliable and valid
Patient self-reporting version of the Healthy Aging Brain Care Monitor -- a primary-care tool to measure cognitive, functional and psychological symptoms -- is user-friendly, reliable and valid, including being sensitive to symptom change, according to new Regenstrief Institute and Indiana University Center for Aging Research study.
NIH/National Institute of Mental Health, NIH/National Institute on Aging

Contact: Cindy Fox Aisen
Indiana University

Public Release: 29-Dec-2014
Protein ID'd as possible universal therapeutic target for many infections, including Ebola
A protein called GRP78 could be a universal therapeutic target for treating human diseases like brain cancer, Ebola, influenza, hepatitis and superbug bacteria such as methicillin-resistant Staphylococcus epidermidis and methicillin-resistant Staphylococcus aureus, according to a Virginia Commonwealth University-led preclinical study published this month in the Journal of Cellular Physiology.
National Institutes of Health, Virginia Commonwealth University

Contact: Brian McNeill
Virginia Commonwealth University

Public Release: 29-Dec-2014
Molecular and Cellular Biology
Enzyme's alter ego helps activate the immune system
Already known to cut proteins, the enzyme SPPL3 turns out to have additional talents, according to a new study from Johns Hopkins. In its newly discovered role, SPPL3 works without cutting proteins to activate T-cells, the immune system's foot soldiers. Because its structure is similar to that of presenilin enzymes, which have been implicated in Alzheimer's disease, the researchers believe their findings could shed more light on presenilin functions, in addition to providing new insight into how the immune system is controlled.
NIH/National Institute of Allergy and Infectious Diseases

Contact: Catherine Kolf
Johns Hopkins Medicine

Public Release: 29-Dec-2014
Text messaging reminders increase second dose influenza vaccinations in children
Researchers studied the impact of text message reminders for the second dose of influenza vaccine required for many young children to protect them against the virus. The findings showed that sending the reminders increased receipt of the second dose of the vaccine and brought children in sooner to be vaccinated. When educational information on the importance of the second dose of influenza vaccine was embedded into the text messages there was an even greater effect.
NIH/National Cancer Institute

Contact: Stephanie Berger
Columbia University's Mailman School of Public Health

Showing releases 2876-2900 out of 3690.

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