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Department of Health and Human Services

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Funded News


Key: Meeting M      Journal J      Funder F

Showing releases 2901-2925 out of 3668.

<< < 112 | 113 | 114 | 115 | 116 | 117 | 118 | 119 | 120 | 121 > >>

Public Release: 20-Jul-2014
Nature Genetics
Common gene variants account for most of the genetic risk for autism
Nearly 60 percent of the risk of developing autism is genetic and most of that risk is caused by inherited variant genes that are common in the population and present in individuals without the disorder, according to a study led by researchers at the Icahn School of Medicine at Mount Sinai and published in the July 20 edition of Nature Genetics.
NIH/National Institute of Mental Health

Contact: Elizabeth Dowling
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine

Public Release: 20-Jul-2014
Nature
Metabolic enzyme stops progression of most common type of kidney cancer
Researchers found that an enzyme called FBP1 -- essential for regulating metabolism -- binds to a transcription factor in the nucleus of certain kidney cells and restrains energy production in the cell body. What's more, they determined that this enzyme is missing from all kidney tumor tissue analyzed. These tumor cells without FBP1 produce energy at a much faster rate than their non-cancer cell counterparts.
Howard Hughes Medical Institute, NIH/National Cancer Institute

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Public Release: 20-Jul-2014
Nature
New findings show strikingly early seeding of HIV viral reservoir
New research finds that the viral reservoir is established substantially earlier after HIV infection than previously recognized.
US Military Research and Material Command, US Military HIV Research Program, Henry M. Jackson Foundation, National Institutes of Health, Ragon Foundation

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center

Public Release: 20-Jul-2014
Nature Genetics
Genetic risk for autism stems mostly from common genes
Using new statistical tools, Carnegie Mellon University's Kathryn Roeder has led an international team of researchers to discover that most of the genetic risk for autism comes from versions of genes that are common in the population rather than from rare variants or spontaneous glitches.
NIH/National Institute of Mental Health

Contact: Shilo Rea
shilo@cmu.edu
412-268-6094
Carnegie Mellon University

Public Release: 19-Jul-2014
20th International AIDS Conference (AIDS 2014)
JAMA
Drug that reduces abdominal fat in HIV patients also may reduce fat in liver
The only drug to receive Food and Drug Administration approval for reduction of the abdominal fat deposits that develop in some patients receiving antiviral therapy for HIV infection may also reduce the incidence of fatty liver disease in such patients. Massachusetts General Hospital investigators report that six months of daily injections of tesamorelin significantly reduced fat in the liver without affecting glucose metabolism.
National Institutes of Health

Contact: Cassandra Aviles
cmaviles@partners.org
617-724-6433
Massachusetts General Hospital

Public Release: 18-Jul-2014
Cell
Immune cell's role in intestinal movement may lead to better understanding of IBS
Learning the role of immune-system cells in healthy digestive tracts and how they interact with neighboring nerve cells may lead to new treatments for irritable bowel syndrome.
National Institutes of Health, Crohn's & Colitis Foundation of America

Contact: Matt Solovey
msolovey@hmc.psu.edu
717-531-8606
Penn State

Public Release: 18-Jul-2014
Arteriosclerosis, Thrombosis and Vascular Biology
Genetic variations may modify cardiovascular benefit of aspirin
A new study suggests that a common genetic variation in the COMT gene may modify the cardiovascular benefit of aspirin, and in some people, may confer slight harm.
NIH/National Heart, Lung, Blood Institute, National Center for Complementary Medicine, NIH/National Cancer Institute

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center

Public Release: 18-Jul-2014
Nature Communications
'Support' cells in brain play important role in Down syndrome
Researchers from UC Davis School of Medicine and Shriners Hospitals for Children -- Northern California have identified a group of cells in the brain that they say plays an important role in the abnormal neuron development in Down syndrome.
NIH/National Institute of Child Health and Human Development, National Multiple Sclerosis Society, Shriners Hospitals for Children, California Institute for Regenerative Medicine, Memorial Hermann Foundation (Staman Ogilvie Fund), Bents

Contact: Charles Casey
charles.casey@ucdmc.ucdavis.edu
916-734-9048
University of California - Davis Health System

Public Release: 17-Jul-2014
National Science Review
PIWI proteins and piRNAs regulate genes in the germline and beyond
PIWI proteins associate with PIWI-interacting RNAs, which are a class of 24-32 nucleotide small non-coding RNAs. Current studies show that PIWI proteins and their interactors regulate piRNA biogenesis and diverse biological processes including transposon silencing, epigenetic programming, DNA rearrangements, mRNA turnover, and translational control, both in the germline and the soma. These discoveries on the PIWI-piRNA pathway have revealed an intriguing new dimension of sncRNA-mediated gene regulation in the cell.
National Institutes of Health, G. Harold & Leila Mathers Foundation, Ellison Medical Foundation Senior Scholar Award

Contact: Haifan Lin
haifan.lin@yale.edu
Science China Press

Public Release: 17-Jul-2014
Huntsman Cancer Institute receives NIH grant to establish national clinical trials site
A team of physician-researchers from Huntsman Cancer Institute at the University of Utah has received nearly $3.6 million over the next five years in a cooperative agreement with the National Institutes of Health to establish a Network Lead Academic Participating Site.
NIH/National Cancer Institute

Contact: Linda Aagard
801-587-7639
University of Utah Health Sciences

Public Release: 17-Jul-2014
Health Psychology
Losing sleep over your divorce? Your blood pressure could suffer
It's normal for people to experience trouble sleeping after a divorce, but if sleep problems last too long, they can lead to potentially harmful increases in blood pressure, a new University of Arizona study finds. The research suggests that poor sleep quality might be one of the reasons divorce is linked to negative health effects.
NIH/National Institute of Mental Health, NIH/National Institute on Aging, NIH/National Institute of Child Health and Human Development

Contact: Alexis Blue
ablue@email.arizona.edu
520-626-4386
University of Arizona

Public Release: 17-Jul-2014
Journal of Human Hypertension
Eating lean beef daily can help lower blood pressure
Contrary to conventional wisdom, a growing body of evidence shows that eating lean beef can reduce risk factors for heart disease, according to recent research by nutritional scientists.
Beef Checkoff Program, National Institutes of Health

Contact: Victoria Indivero
vmi1@psu.edu
814-865-9481
Penn State

Public Release: 17-Jul-2014
Journal of Immunology
GW researcher unlocks next step in creating HIV-1 immunotherapy using fossil virus
Douglas Nixon, chair of the Department of Microbiology, Immunology, and Tropical Medicine at the George Washington University School of Medicine and Health Sciences, was published in the Cutting Edge section of the Journal of Immunology for his discovery of an antibody that can neutralize the HIV-1 fossil virus. This may lead to finding a viable immunotherapy option for HIV-1.
National Institutes of Health, Bill and Melinda Gates Foundation, The Foundation for AIDS Research, The Peter And Shelagh Godsoe Family Foundation

Contact: Lisa Anderson
lisama2@gwu.edu
202-994-3121
George Washington University

Public Release: 17-Jul-2014
Biochemical and Biophysical Research Communications
Lipoic acid helps restore, synchronize the 'biological clock'
Researchers have discovered a possible explanation for the surprisingly large range of biological effects that are linked to a micronutrient called lipoic acid: It appears to reset and synchronize circadian rhythms, or the 'biological clock' found in most life forms.
National Institutes of Health

Contact: Tory Hagen
tory.hagen@oregonstate.edu
541-737-5083
Oregon State University

Public Release: 17-Jul-2014
Hepatology
Transplant patients who receive livers from living donors more likely to survive
The first data-driven study in over a decade disputes the notion that deceased donor liver transplants offer patients better survival rates. Penn Medicine researchers found that living donor transplant outcomes are superior to those found with deceased donors with appropriate donor selection and when surgeries are performed at an experienced center. The research is published this week in the journal Hepatology.
National Institutes of Health

Contact: Lee-Ann Donegan
leeann.donegan@uphs.upenn.edu
215-349-5660
University of Pennsylvania School of Medicine

Public Release: 17-Jul-2014
PLOS Genetics
Scripps Florida scientists identify gene that plays a surprising role in combating aging
Scientists from the Florida campus of The Scripps Research Institute have found in animal models that a single gene plays a surprising role in aging that can be detected early in development, a discovery that could point toward the possibility of one day using therapeutics, even some commonly used ones, to manipulate the aging process itself.
Ellison Medical Foundation, Glenn Foundation for Medical Research, A-T Children's Project, NIH/National Institute of Aging, National Institute of General Medical Sciences

Contact: Eric Sauter
esauter@scripps.edu
267-337-3859
Scripps Research Institute

Public Release: 17-Jul-2014
Journal of Biological Chemistry
Crohn's disease research
University of Delaware researchers have identified a protein, hiding in plain sight, that acts like a bodyguard to help protect and stabilize another key protein, that when unstable, is involved in Crohn's disease. The fundamental research points to a possible pathway for developing an effective therapy for the inflammatory bowel disease.
National Institutes of Health

Contact: Donna O'Brien
dobrien@udel.edu
University of Delaware

Public Release: 17-Jul-2014
Neuron
International research team discovers genetic dysfunction connected to hydrocephalus
The mysterious condition once known as 'water on the brain' became less murky, thanks to a global research group led in part by a Case Western Reserve researcher. Anthony Wynshaw-Boris, MD, PhD, is the co-principal investigator on a study that illustrates how the domino effect of one genetic error can contribute to excessive cerebrospinal fluid surrounding the brains of mice -- a disorder known as hydrocephalus. The findings appear online July 17 in the journal Neuron.
National Institutes of Health

Contact: Jeannette Spalding
jeannette.spalding@case.edu
216-368-3004
Case Western Reserve University

Public Release: 17-Jul-2014
Frontiers in Public Health
NYU research on persons w/ HIV/AIDS not taking medication and not engaged in care
The study describes factors believed to contribute to these critical public health issues, with a focus on African American and Latino/Hispanic PLHAs, the racial/ethnic groups most affected by HIV/AIDS.
NIH/National Institutes of Mental Health

Contact: Christopher James
christopher.james@nyu.edu
212-998-6876
New York University

Public Release: 17-Jul-2014
Technology
Potential new therapy with brain-on-a-chip axonal strain injury model
Researchers from the Biomedical Engineering Department of Rutgers, The State University of New Jersey recently demonstrated the use of their 'Brain-on-a-Chip' microsystem to assess specific effects of traumatic axonal injury.
New Jersey Commission for Brain Injury, Research, NIH/National Institute of Biomedical Imaging and Bioengineering, NIH/National Institute of General Medical Sciences

Contact: Philly Lim
mllim@wspc.com
65-646-65775
World Scientific

Public Release: 17-Jul-2014
Science
Scientists find protein-building enzymes have metamorphosed & evolved new functions
Scientists at The Scripps Research Institute and Hong Kong University of Science and Technology and their collaborators have found that ancient enzymes, known for their fundamental role in translating genetic information into proteins, evolved myriad other functions in humans. The surprising discovery highlights an intriguing oddity of protein evolution as well as a potentially valuable new class of therapeutic proteins and therapeutic targets.
HHong Kong Government's Innovation and Technology Fund, National Foundation for Cancer Research, National Institutes of Health, aTyr Pharma, Pangu Biopharma

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute

Public Release: 17-Jul-2014
PLOS Genetics
Pitt-led study suggests cystic fibrosis is 2 diseases, 1 doesn't affect lungs
Cystic fibrosis could be considered two diseases, one that affects multiple organs including the lungs, and one that doesn't affect the lungs at all, according to a multicenter team led by researchers at the University of Pittsburgh School of Medicine. The research, published online today in PLOS Genetics, showed that nine variants in the gene associated with cystic fibrosis can lead to pancreatitis, sinusitis and male infertility, but leave the lungs unharmed.
National Institutes of Health, Ministry for Health & Welfare, Republic of Korea, Brain Korea 21 Project for Medical Sciences, Seoul

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences

Public Release: 17-Jul-2014
PLOS Genetics
In development, it's all about the timing
Closely related organisms share most of their genes, but these similarities belie major differences in behavior, intelligence, and physical appearance. Scientists are beginning to appreciate that the timing of the events that happen during development plays a decisive role in defining an organism. Today, a team of scientists at CSHL has identified LIN-42 as a key regulator of developmental timing, governing a broad range of events throughout maturation.
Rita Allen Foundation, National Institutes of Health, Robertson Research Fund of Cold Spring Harbor Laboratory

Contact: Jaclyn Jansen
jjansen@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory

Public Release: 17-Jul-2014
Cell
Faithful cell division requires tightly controlled protein placement at the centromeres
The protein CENP-A, which is integrated into human DNA at the centromere on each chromosome, has a vital role in cell division. Work from Whitehead Institute Member Iain Cheeseman's lab describes how the vital and tightly controlled replenishment of CENP-A progresses.
Leukemia and Lymphoma Society, National Institutes of Health, American Cancer Society

Contact: Nicole Giese Rura
rura@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research

Public Release: 17-Jul-2014
Cell Reports
First comprehensive library of master genetic switches in plants
Researchers have created the first comprehensive library of genetic switches in plants, setting the stage for scientists around the globe to better understand how plants adapt to environmental changes and to design more robust plants for future food security.
NIH/National Institute of General Medical Sciences

Contact: Suzanne Wu
suzanne.wu@usc.edu
213-740-0252
University of Southern California

Showing releases 2901-2925 out of 3668.

<< < 112 | 113 | 114 | 115 | 116 | 117 | 118 | 119 | 120 | 121 > >>

     
   

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