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Department of Health and Human Services

News from the National Institutes of Health

Funded News

Key: Meeting M      Journal J      Funder F

Showing releases 2951-2975 out of 3494.

<< < 114 | 115 | 116 | 117 | 118 | 119 | 120 | 121 | 122 | 123 > >>

Public Release: 12-Dec-2013
Cancer Research
Researchers hope newly discovered gene interaction could lead to novel cancer therapies
Scientists from Virginia Commonwealth University Massey Cancer Center have revealed how two genes interact to kill a wide range of cancer cells. Originally discovered by the study's lead investigator Paul B. Fisher, M.Ph., Ph.D., the genes known as mda-7/IL-24 and SARI could potentially be harnessed to treat both primary and metastatic forms of brain, breast, colon, lung, ovary, prostate, skin and other cancers.
National Institutes of Health

Contact: John Wallace
Virginia Commonwealth University

Public Release: 12-Dec-2013
The Journal of Neuroscience
Scientists improve human self-control through electrical brain stimulation
If you have ever said or done the wrong thing at the wrong time, you should read this. Neuroscientists at The University of Texas Health Science Center at Houston and the University of California, San Diego, have successfully demonstrated a technique to enhance a form of self-control through a novel form of brain stimulation.
NIH/National Institutes of Health Center for Clinical and Translational Sciences

Contact: Robert Cahill
University of Texas Health Science Center at Houston

Public Release: 12-Dec-2013
2013 CTRC-AACR San Antonio Breast Cancer Symposium
Cell Reports
New models of drug-resistant breast cancer point to better treatments
Human breast tumors transplanted into mice are excellent models of metastatic cancer and are providing insights into how to attack breast cancers that no longer respond to the drugs used to treat them, according to research from Washington University School of Medicine in St. Louis.
Susan G. Komen for the Cure, National Institutes of Health

Contact: Julia Evangelou Strait
Washington University School of Medicine

Public Release: 12-Dec-2013
Wayne State discovers potential treatment for skin and corneal wound healing in diabetics
A team of Wayne State University researchers recently developed several diabetic models to study impaired wound healing in diabetic corneas. Using a genome-wide cDNA array analysis, the group identified genes, their associated pathways and the networks affected by DM in corneal epithelial cells and their roles in wound closure. Their findings may bring scientists one step closer to developing new treatments that may slow down or thwart the impact on vision.
NIH/National Eye Institute

Contact: Julie O'Connor
Wayne State University - Office of the Vice President for Research

Public Release: 12-Dec-2013
Sniffing out danger: Rutgers scientists say fearful memories can trigger heightened sense of smell
Neuroscientists at Rutgers University studying the olfactory -- sense of smell -- system in mice have discovered that fear reaction can occur at the sensory level, even before the brain has the opportunity to interpret that the odor could mean trouble.
NIH/National Institute of Mental Health, NIH/National Institute on Deafness and Other Communication Disorders

Contact: Robin Lally
732-932-7084 x652
Rutgers University

Public Release: 12-Dec-2013
Blind cavefish offer evidence for alternative mechanism of evolutionary change
In a blind fish that dwells in deep, dark Mexican caves, scientists have found evidence for a long-debated mechanism of evolutionary change that is distinct from natural selection of spontaneously arising mutations, as reported this week in the journal Science.
National Institutes of Health

Contact: Diana Kenney
Marine Biological Laboratory

Public Release: 12-Dec-2013
Speeding up gene discovery
MIT researchers develop a new gene-editing system that enables large-scale studies of gene function.
National Institutes of Health, NIH/National Human Genome Research Institute, Broad Institute, National Science Foundation, Klarman Cell Observatory, Simons Center, and others

Contact: Sarah McDonnell
Massachusetts Institute of Technology

Public Release: 12-Dec-2013
San Antonio Breast Cancer Symposium
Mayo Clinic: First in-human trial of endoxifen shows promise as breast cancer treatment
A Phase I trial of endoxifen, an active metabolite of the cancer drug tamoxifen, indicates that the experimental drug is safe, with early evidence for anti-tumor activity, a Mayo Clinic study has found. The findings indicate that Z-endoxifen, co-developed by Mayo Clinic Cancer Center and the National Cancer Institute, may provide a new and better treatment for some women with estrogen positive breast cancer and, in particular, for those women who do not respond to tamoxifen and aromatase inhibitors.
National Institutes of Health

Contact: Joe Dangor
Mayo Clinic

Public Release: 12-Dec-2013
Scientists discover double meaning in genetic code
Scientists have discovered a second code hiding within DNA. The second code contains information that changes how scientists read the instructions contained in DNA and interpret mutations to make sense of health and disease. Genomes use the genetic code to write two separate languages. One describes how proteins are made, and the other instructs the cell on how genes are controlled. One language is written on top of the other.
National Institutes of Health, NIH/National Institute of Diabetes and Digestive and Kidney Diseases

Contact: Leila Gray
University of Washington

Public Release: 12-Dec-2013
Rapid evolution of novel forms: Environmental change triggers inborn capacity for adaptation
In this week's edition of the journal Science, a team of researchers from Harvard Medical School and Whitehead Institute report that, at least in the case of one variety of cavefish, one agent of evolutionary change is the heat shock protein known as HSP90.
National Institutes of Health and the Damon Runyon Cancer Research Foundation

Contact: Matt Fearer
Whitehead Institute for Biomedical Research

Public Release: 12-Dec-2013
First step of metastasis halted in mice with breast cancer
Cell biologists at Johns Hopkins have identified a unique class of breast cancer cells that lead the process of invasion into surrounding tissues. Because invasion is the first step in the deadly process of cancer metastasis, the researchers say they may have found a weak link in cancer's armor and a possible new target for therapy.
NIH/National Cancer Institute, NIH/National Institute of Environmental Health Sciences, US Department of Defense CDMRP Breast Cancer Program, Avon Foundation, Mary Kay Foundation, Safeway Foundation, Cindy Rosencrans Fund for Triple Negative Breast Cancer

Contact: Catherine Kolf
Johns Hopkins Medicine

Public Release: 12-Dec-2013
American Journal of Pathology
Enzyme BACE1 may be important in predicting onset of Alzheimer disease
The critical enzyme beta-secretase1 (BACE1) is known to be elevated in brains with sporadic Alzheimer disease (AD). Scientists have now found increased levels of BACE1 in brains with mild cognitive impairment, suggesting that BACE1 activity is important for conversion of mild cognitive impairment to AD and may be an early indicator of AD. The results are published in the January issue of The American Journal of Pathology.
National Institutes of Health, Alzheimer Association, National Natural Science Foundation of China

Contact: Eileen Leahy
Elsevier Health Sciences

Public Release: 12-Dec-2013
Salmonella jams signals from bacteria-fighting mast cells
A protein in Salmonella inactivates mast cells -- critical players in the body's fight against bacteria and other pathogens -- rendering them unable to protect against bacterial spread in the body, according to researchers at Duke Medicine and Duke-National University of Singapore.
National Institutes of Health, Duke-NUS

Contact: Rachel Harrison
Duke University Medical Center

Public Release: 12-Dec-2013
Cell Reports
Temple scientists studying mitochondrial calcium handling yield new disease targets
When things go wrong, cells turn to built-in safety mechanisms for survival. One of those mechanisms involves calcium uptake by mitochondria, the energy-producing powerhouses of cells. Long a mystery, new research by scientists at the Temple University School of Medicine Center for Translational Research shows exactly how mitochondria handle damaging excess calcium from the intracellular environment, and how problems with calcium regulation can lead to vascular damage.
National Institutes of Health

Contact: Jeremy Walter
Temple University Health System

Public Release: 12-Dec-2013
Cell Reports
Combining mutants results in 5-fold lifespan extension in C. elegans
What are the limits to longevity? Scientists at the Buck Institute combined mutations in two pathways well-known for lifespan extension and report a synergistic five-fold lifespan extension in the nematode C. elegans. The worms lived to the human equivalent of 400 to 500 years. The research introduces the possibility of combination therapy for aging and could help explain why scientists are having a difficult time identifying single genes responsible for long lives in human centenarians.
National Institutes of Health, American Federation for Aging Research, Hillblom Foundation

Contact: Kris Rebillot
Buck Institute for Age Research

Public Release: 12-Dec-2013
2013 CTRC-AACR San Antonio Breast Cancer Symposium
Exercise improves drug-associated joint pain in breast cancer survivors
Breast cancer survivors taking aromatase inhibitors such as anastrozole, letrozole, and exemestane experienced a reduction in joint pain if they exercised while on treatment, according to results presented here at the 2013 San Antonio Breast Cancer Symposium, held Dec. 10-14.
NIH/National Cancer Institute

Contact: Jeremy Moore
American Association for Cancer Research

Public Release: 11-Dec-2013
Journal of Vision
Trained airport checkpoint screeners miss rare targets
Holiday travelers will be relieved to know that security threats are rarely encountered at airport checkpoints. But according to a new study published in the Journal of Vision, the low frequency at which trained airport screeners find threats reduces the chances targets will be found.
US Deptartment of Homeland Security, Transporation Security Administration, National Institutes of Health

Contact: Katrina Norfleet
Association for Research in Vision and Ophthalmology

Public Release: 11-Dec-2013
Liquid to gel to bone
Rice bioengineers have developed a hydrogel scaffold for craniofacial bone tissue regeneration that starts as a liquid, solidifies into a gel in the body and liquefies again for removal.
National Institutes of Health, Baylor College of Medicine Scientific Training Program for Dental Academic Researchers

Contact: David Ruth
Rice University

Public Release: 11-Dec-2013
Science Translational Medicine
Dietary amino acids improve sleep problems in mice with traumatic brain injury
Scientists have discovered how to fix sleep disturbances in mice with traumatic brain injuries -- a discovery that could lead to help for hundreds of thousands of people who have long-term and debilitating sleep and wakefulness issues after they suffer concussions.
National Institutes of Health

Contact: Todd Murphy
Oregon Health & Science University

Public Release: 11-Dec-2013
Current Biology
Researchers at Penn show optimal framework for heartbeats
There is an optimal amount of strain that a beating heart can generate and still beat at its usual rate, once per second. Researchers at the University of Pennsylvania have now shown that this "sweet spot" depends on the stiffness of the collagen framework that the heart's cells live within.
National Institutes of Health, National Science Foundation

Contact: Evan Lerner
University of Pennsylvania

Public Release: 11-Dec-2013
Aging Cell
Sleep-deprived mice show connections among lack of shut-eye, diabetes, age
For the first time, researchers describe the effect of sleep deprivation on the unfolded protein response in peripheral tissue. Stress in pancreatic cells due to sleep deprivation may contribute to the loss or dysfunction of cells important to maintaining proper blood sugar levels, and that these functions may be exacerbated by normal aging. The combined effect of aging and sleep deprivation resulted in a loss of control of blood sugar, somewhat like pre-diabetes in mice.
NIH/National Institute of Diabetes and Digestive and Kidney Diseases, NIH/National Institute on Aging

Contact: Karen Kreeger
University of Pennsylvania School of Medicine

Public Release: 11-Dec-2013
Proceedings of the National Academy of Sciences
Staying ahead of Huntington's disease
Rohit Pappu, Ph.D., and his colleagues are working to stay ahead of Huntington's disease, a devastating, incurable disorder that results from the death of certain neurons in the brain
National Institutes of Health

Contact: Neil Schoenherr
Washington University in St. Louis

Public Release: 11-Dec-2013
Boston Hospital Trio awarded $25 million NIH grant to study critical limb ischemia
A team of researchers from Brigham and Women's Hospital, Boston Medical Center and Massachusetts General Hospital has been awarded $25 million by the National Institutes of Health to conduct a four-year, randomized clinical trial -- the BEST-CLI Trial (Best Endovascular versus Best Surgical Therapy in Patients with Critical Limb Ischemia).
National Institutes of Health

Contact: Marjorie Montemayor-Quellenberg
Brigham and Women's Hospital

Public Release: 11-Dec-2013
IU-designed probe opens new path for drug development against leading STD
Biochemical sleuthing by an Indiana University graduate student has ended a nearly 50-year-old search to find a megamolecule in bacterial cell walls commonly used as a target for antibiotics, but whose presence had never been identified in the bacterium responsible for the most commonly reported sexually transmitted disease in the United States.
National Institutes of Health

Contact: Stephen Chaplin
Indiana University

Public Release: 11-Dec-2013
Developmental Cell
1 protein, 2 personalities: Penn team identifies new mechanism of cancer spread
A new finding by University of Pennsylvania scientists has identified key steps that trigger the disintegration of cellular regulation that leads to cancer. Their discovery -- that a protein called Exo70 has a split personality, with one form keeping cells under tight control and another contributing to the ability of tumors to invade distant parts of the body -- points to new possibilities for diagnosing cancer metastasis.
National Institutes of Health

Contact: Katherine Unger Baillie
University of Pennsylvania

Showing releases 2951-2975 out of 3494.

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