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Department of Health and Human Services

News from the National Institutes of Health

Funded News

Key: Meeting M      Journal J      Funder F

Showing releases 2951-2975 out of 3458.

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Public Release: 14-Oct-2013
Cell Host & Microbe
Mammalian body cells lack ancient viral defense mechanism, find UT scientists
The first positive evidence that RNA interference does not play a role as an antiviral in most body, or "somatic," cells in mammals has been provided by a team led by Chris Sullivan at The University of Texas at Austin.
National Science Foundation Career, National Institutes of Health, Burroughs Wellcome Pathogenesis of Infectious Diseases Award

Contact: Chris Sullivan
University of Texas at Austin

Public Release: 14-Oct-2013
Journal of Molecular and Cellular Cardiology
Adult stem cells help build human blood vessels in engineered tissues
Researchers at the University of Illinois at Chicago have identified a protein expressed by human bone marrow stem cells that guides and stimulates the formation of blood vessels. Their findings, which could help improve the vascularization of engineered tissues, were reported online on October 12 in the Journal of Molecular and Cellular Cardiology.
National Institutes of Health, Heart Research Foundation

Contact: Sharon Parmet
University of Illinois at Chicago

Public Release: 14-Oct-2013
Study: Gunshot injuries in children are more severe, deadly, costly than any other injury source
A research team led by Oregon Health & Science University and the University of California, Davis, reveals that childhood gunshot injuries, while uncommon, are more severe, require more major surgery, have greater mortality and higher per-patient costs than any other mechanism for childhood injury -- particularly among adolescent males. The study is published online in the journal Pediatrics.
Robert Wood Johnson Foundation, California Wellness Foundation, National Institutes of Health

Contact: Tamara Hargens-Bradley
Oregon Health & Science University

Public Release: 14-Oct-2013
Proceedings of the National Academy of Sciences
From football to flies: Lessons about traumatic brain injury
Faced with news of suicides and brain damage in former professional football players, geneticist Barry Ganetzky bemoaned the lack of model systems for studying the insidious and often delayed consequences linked to head injuries.
National Institutes of Health

Contact: Barry Ganetzky
University of Wisconsin-Madison

Public Release: 14-Oct-2013
Kidney failure can complicate long-term outcomes in children receiving solid-organ transplants
Children who undergo transplants of solid organs have a high risk of developing advanced kidney disease, according to a new national study. Among these children, the highest risk is in those receiving lung or intestinal transplants, followed by heart and then liver transplants. The researchers say their findings reinforce the importance of continued screening of kidney function in pediatric transplant recipients.
National Institutes of Health, National Kidney Foundation, Nephcure Foundation

Contact: John Ascenzi
Children's Hospital of Philadelphia

Public Release: 14-Oct-2013
Football-shaped particles bolster the body's defense against cancer
Researchers at Johns Hopkins have succeeded in making flattened, football-shaped artificial particles that impersonate immune cells. These football-shaped particles seem to be better than the typical basketball-shaped particles at teaching immune cells to recognize and destroy cancer cells in mice.
NIH/National Institute of Allergy and Infectious Diseases, NIH/National Cancer Institute, NIH/National Institute of Biomedical Imaging and Bioengineering, Johns Hopkins University Institute for NanoBioTechnology

Contact: Catherine Kolf
Johns Hopkins Medicine

Public Release: 13-Oct-2013
The role of 'master regulators' in gene mutations and disease
Researchers at the University of California, San Diego School of Medicine have developed a new way to parse and understand how special proteins called "master regulators" read the genome, and consequently turn genes on and off.
National Institutes of Health, Foundation Leducq Career Development award

Contact: Scott LaFee
University of California - San Diego

Public Release: 13-Oct-2013
Nature Methods
Database of disease genes shows potential drug therapies
Researchers at Washington University School of Medicine in St. Louis have created a massive online database that matches thousands of genes linked to cancer and other diseases with drugs that target those genes. Some of the drugs are approved by the US Food and Drug Administration, while others are in clinical trials or just entering the drug development pipeline.
NIH/National Human Genome Research Institute

Contact: Caroline Arbanas
Washington University School of Medicine

Public Release: 13-Oct-2013
Nature Genetics
Study identifies 4 genetic variants linked to esophageal cancer and Barrett's esophagus
An international consortium co-led by researchers at Fred Hutchinson Cancer Research Center and the QIMR Berghofer Medical Research Institute in Australia has identified four genetic variants associated with an increased risk of esophageal cancer and its precursor, a condition called Barrett's esophagus.
NIH/National Cancer Institute

Contact: Kristen Woodward
Fred Hutchinson Cancer Research Center

Public Release: 13-Oct-2013
Nature Genetics
In a surprise finding, gene mutation found linked to low-risk bladder cancer
An international research team has discovered a genetic mutation linked to low-risk bladder cancer. The investigators identified STAG2 as one of the most commonly mutated genes in bladder cancer, particularly in tumors that do not spread. The finding suggests that checking the status of the gene may help identify patients who might do unusually well following cancer treatment.
National Institutes of Health, MD Anderson Cancer Center Bladder Cancer SPORE grant

Contact: Karen Mallet
Georgetown University Medical Center

Public Release: 11-Oct-2013
$6.4 million grant funds glaucoma study in African-Americans
A study led by Robert N. Weinreb, chairman and Distinguished Professor of Ophthalmology at the University of California, San Diego School of Medicine, has received a $6.4 million, five-year grant from the National Eye Institute, part of the National Institutes of Health, to elucidate the genetics of glaucoma in persons of African descent.
National Institutes of Health

Contact: Debra Kain
University of California - San Diego

Public Release: 11-Oct-2013
Cell Metabolism
Scientists identify protein linking exercise to brain health
A protein that is increased by endurance exercise has been isolated and given to non-exercising mice, in which it turned on genes that promote brain health and encourage the growth of new nerves involved in learning and memory, report scientists from Dana-Farber Cancer Institute and Harvard Medical School.
JPB Foundation, National Institutes of Health

Contact: Robbin Ray
Dana-Farber Cancer Institute

Public Release: 11-Oct-2013
PLOS Pathogens
UC Irvine scientists help identify possible botulism blocker
US and German scientists have decoded a key molecular gateway for the toxin that causes botulism, pointing the way to treatments that can keep the food-borne poison out of the bloodstream.
NIH/National Institute of Allergy and Infectious Diseases, US Department of Agriculture CRIS Project

Contact: Tom Vasich
University of California - Irvine

Public Release: 10-Oct-2013
University of Utah awarded $20.4 million from NIH to advance translational research in medicine
The Center's track record of success this month has earned it a $20.4 million grant from the National Institutes of Health that will allow it to provide support for all aspects of translational research over the next five years.
National Institutes of Health

Contact: Melinda Rogers
University of Utah Health Sciences

Public Release: 10-Oct-2013
Molecular Psychiatry
Sticks and stones: Brain releases natural painkillers during social rejection, U-M study finds
"Sticks and stones may break my bones, but words will never hurt me," goes the playground rhyme that's supposed to help children endure taunts from classmates. But a new study suggests that there's more going on inside our brains when someone snubs us -- and that the brain may have its own way of easing social pain.
National Institutes of Health, Brain & Behavior Research Foundation, Phil F. Jenkins Foundation

Contact: Kara Gavin
University of Michigan Health System

Public Release: 10-Oct-2013
Cleveland institutions receive NIH grant for regional stroke clinical trials coordinating center
Five Cleveland biomedical research and health care institutions have received a $1 million grant from the National Institute of Neurological Disorders and Stroke, one of the National Institutes of Health, to collaborate on developing the Cleveland Stroke Clinical Trials Regional Coordinating Center.
NIH/National Institute of Neurological Disorders and Stroke

Contact: Amanda Petrak
Case Western Reserve University

Public Release: 10-Oct-2013
Journal of Clinical Oncology
Preventable risk factors pose serious threat to heart health of childhood cancer survivors
For childhood cancer survivors, risk factors associated with lifestyle, particularly hypertension, dramatically increase the likelihood of developing serious heart problems as adults, according to a national study led by St. Jude Children's Research Hospital.
NIH/National Cancer Institute, ALSAC

Contact: Summer Feeman
St. Jude Children's Research Hospital

Public Release: 10-Oct-2013
The Cancer Genome Atlas exposes more secrets of lethal brain tumor
Scientists at UT MD Anderson Cancer Center and collaborators paint a more detailed picture of the genomic abnormalities that drive glioblastoma multiforme. Rich data set will underpin research and treatment advances.
National Institutes of Health/The Cancer Genome Atlas

Contact: Scott Merville
University of Texas M. D. Anderson Cancer Center

Public Release: 10-Oct-2013
After almost a century, a question answered; genes protect themselves against being silenced
Harvard Stem Cell Institute researchers have settled a century-old debate over whether occurrence of DNA methylation acts to silence gene expression, or if genes are turned off by other means before they are methylated.
National Institutes of Health

Contact: B. D. Colen
Harvard University

Public Release: 10-Oct-2013
Science Signalling
Scientists find potential new targets for anti-inflammatory therapies
A team led by scientists at The Scripps Research Institute has identified key signaling proteins in the inflammation process that contribute to the development of inflammatory diseases such as rheumatoid arthritis, psoriasis, sepsis and inflammatory bowel diseases. The finding highlights possible new ways of treating these inflammation disorders, which sicken or kill millions of people around the world each year.
National Institutes of Health

Contact: Mika Ono
Scripps Research Institute

Public Release: 10-Oct-2013
Super-enhancers seen as 'Rosetta Stone' for dialog between genes and disease
Having recently discovered a set of powerful gene regulators that control cell identity in a few mouse and human cell types, Whitehead Institute scientists are now showing that these regulators -- which they named "super-enhancers" -- act across a vast array of human cell types and are enriched in mutated regions of the genome that are closely associated with a broad spectrum of diseases.
National Institutes of Health

Contact: Matt Fearer
Whitehead Institute for Biomedical Research

Public Release: 10-Oct-2013
Newly discovered gene regulator could precisely target sickle cell disease
A research team from Dana-Farber/Boston Children's Cancer and Blood Disorders Center and other institutions has discovered a new genetic target for potential therapy of sickle cell disease. The target, called an enhancer, controls a molecular switch in red blood cells called BCL11A that, in turn, regulates hemoglobin production. The researchers -- led by Daniel Bauer, M.D., Ph.D., and Stuart Orkin, M.D., of Dana-Farber/Boston Children's -- reported their findings today in Science.
NIH/National Heart, Lung and Blood Institute, NIH/National Institute of Diabetes and Digestive and Kidney Diseases, Doris Duke Charitable Foundation, Howard Hughes Medical Institute

Contact: Irene Sege
Dana-Farber Cancer Institute

Public Release: 10-Oct-2013
Current Biology
Look out above! Experiment explores innate visual behavior in mice
For a mouse in the wild, spotting aerial predators -- like hawks and owls -- is essential to survival. But how is this visual cue processed into a behavior that helps avoid an attack? Using a video technique, researchers at Caltech have developed a simple stimulus to spur the mouse's defense plans: to freeze in place, or flee for cover. These visual behaviors also provide information about cell types in the retina responsible for detecting aerial predators.
National Institutes of Health

Contact: Deborah Williams-Hedges
California Institute of Technology

Public Release: 10-Oct-2013
Cell Metabolism
Eat more, weigh less: Worm study provides clues to better fat-loss therapies for humans
Scientists at The Scripps Research Institute have discovered key details of a brain-to-body signaling circuit that enables roundworms to lose weight independently of food intake. The weight-loss circuit is activated by combined signals from the worm versions of the neurotransmitters serotonin and adrenaline, and there are reasons to suspect that it exists in a similar form in humans and other mammals.
NIH/National Institute for Diabetes, Digestive and Kidney Disorders

Contact: Mika Ono
Scripps Research Institute

Public Release: 10-Oct-2013
Researchers identify liver cancer progenitor cells before tumors become visible
For the first time, researchers at the University of California, San Diego School of Medicine have isolated and characterized the progenitor cells that eventually give rise to malignant hepatocellular carcinoma (HCC) tumors -- the most common form of liver cancer. The researchers found ways to identify and isolate the HCC progenitor cells long before actual tumors were apparent.
Superfund Basic Research Program, National Institutes of Health, Wellcome Trust, American Diabetes Association

Contact: Scott LaFee
University of California - San Diego

Showing releases 2951-2975 out of 3458.

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