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Department of Health and Human Services

News from the National Institutes of Health

Funded News


Key: Meeting M      Journal J      Funder F

Showing releases 2951-2975 out of 3499.

<< < 114 | 115 | 116 | 117 | 118 | 119 | 120 | 121 | 122 | 123 > >>

Public Release: 19-Dec-2013
PLOS Genetics
Protein links liver cancer with obesity, alcoholism, and hepatitis
A new study identifies an unexpected molecular link between liver cancer, cellular stress, and risk factors for developing this cancer -- obesity, alcoholism, and viral hepatitis. In the study by University of Iowa researchers and published in the journal PLOS Genetics, researchers show that a protein called CHOP, which had previously been thought to generally protect against cancer, actually promotes liver cancer in mice.
NIH/National Institute of Diabetes and Digestive and Kidney Diseases, Carver Medical Research Trust Initiative, NIH/National Cancer Institute

Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
PLOS

Public Release: 19-Dec-2013
Scientists look to tackle bacterium that is major cause of diarrhea, vomiting
Scientists want to make a chink in the armor of a bacterium that has little name recognition yet is the number-one bacterial cause of the diarrhea, vomiting and stomach pain Americans experience annually.
National Institutes of Health

Contact: Toni Baker
tbaker@gru.edu
706-721-4421
Medical College of Georgia at Georgia Regents University

Public Release: 19-Dec-2013
Cell
Researchers find a cause of aging that can be reversed
Medical researchers have found a cause of ageing in animals that can be reversed, possibly paving the way for new treatments for age-related diseases including cancer, type 2 diabetes, muscle wasting and inflammatory diseases.
NIH/National Institute on Aging, Glenn Foundation for Medical Research

Contact: Susi Hamilton
susi.hamilton@unsw.edu.au
61-422-934-024
University of New South Wales

Public Release: 19-Dec-2013
Current Biology
Renegades of cell biology: Why K-Ras gene mutations prove so deadly in cancer
Cells with a mutation in the gene called K-Ras—found in close to 30 percent of all cancers, but mostly those with worst prognosis, such as pancreatic cancer, colon cancer, and lung cancer -- behave in ways that subvert the normal mechanisms of cell death, according to a cell-culture study by researchers from Huntsman Cancer Institute at the University of Utah.
National Institutes of Health

Contact: Linda Aagard
801-587-7639
University of Utah Health Sciences

Public Release: 19-Dec-2013
PLOS Genetics
Amino acid's increase is suspected in diabetes
Scientists at The University of Texas Health Science Center at San Antonio conducted research that suggests the amino acid tyrosine has a direct effect in diabetes.
NIH/National Institute on Aging, National Institute of Environmental Health Sciences, Geriatric Research, Education and Clinical Center of the South Texas Veterans Health Care System

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio

Public Release: 19-Dec-2013
PLOS Pathogens
Biologists find clues to a parasite's inconsistency
MIT researchers find that certain strains of Toxoplasma provoke inflammation that can damage host cells, while others are harmless.
New England Regional Center of Excellence, Pew Scholars Program in the Biomedical Sciences, Robert A. Swanson Career Development Award, Knights Templar Eye Foundation, Wellcome Trust Foundation, National Institutes of Health

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology

Public Release: 19-Dec-2013
Cell Stem Cell
Brain repair after injury and Alzheimer's disease
Scientists at Penn State University have developed an innovative technology to regenerate functional neurons after brain injury. The technology may be developed into a new therapeutic treatment for traumatic brain and spinal cord injuries, stroke, Alzheimer's disease, Parkinson's disease, and other neurological disorders.
National Institutes of Health, Penn State University Eberly College of Science

Contact: Barbara K. Kennedy
science@psu.edu
81-488-634-682
Penn State

Public Release: 19-Dec-2013
PLOS Genetics
Protein links liver cancer with obesity, alcoholism, and hepatitis
A new study identifies an unexpected molecular link between liver cancer, cellular stress, and risk factors for developing this cancer -- obesity, alcoholism, and viral hepatitis. The study by University of Iowa researchers shows that a protein called CHOP, which had previously been thought to generally protect against cancer, actually promotes liver cancer in mice and may do the same in humans. The findings are published Dec. 19 in the journal PLOS Genetics.
NIH/National Institute of Diabetes, Digestive, and Kidney Disorders

Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-356-7124
University of Iowa Health Care

Public Release: 19-Dec-2013
Nature
Gladstone scientists discover how immune cells die during HIV infection; identify potential drug to block AIDS
Research led by scientists at the Gladstone Institutes has identified the chain of molecular events that drives the death of the immune system's CD4 T cells as an HIV infection leads to AIDS. Further, they have identified an existing anti-inflammatory drug that blocks the death of these cells -- and now are planning a Phase 2 clinical trial to determine if it can prevent HIV-infected people from developing AIDS.
National Institutes of Health, A.P. Giannini Postdoctoral Research Fellowship, University of California San Francisco/Robert John Sabo Trust Award

Contact: Anne Holden
anne.holden@gladstone.ucsf.edu
415-734-2534
Gladstone Institutes

Public Release: 19-Dec-2013
Stroke: Journal of the American Heart Association
Anxiety linked to higher long-term risk of stroke
This is the first study to link anxiety to a greater risk of stroke.
NIH/National Heart, Lung, and Blood Institute, NIH/National Institute of Mental Health

Contact: Darcy Spitz
darcy.spitz@heart.org
212-878-5940
American Heart Association

Public Release: 19-Dec-2013
Science
Team finds new way to map important drug targets
Researchers have used new techniques and one of the brightest X-ray sources on the planet to map the 3-D structure of an important cellular gatekeeper in a more natural state than possible before.
National Institutes of Health, National Science Foundation

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute

Public Release: 19-Dec-2013
PLOS Genetics
Stowers researchers announce first genetic model of a human jaw fusion defect known as syngnathia
The face you critiqued in the mirror this morning was sculpted before you were born by a transient population of cells called neural crest cells. Those cells spring from neural tissue of the brain and embryonic spinal cord and travel throughout the body, where they morph into highly specialized bone structures, cartilage, connective tissue, and nerve cells.
NIH/National Institute of Dental and Craniofacial Research, March of Dimes, and others

Contact: Gina Kirchweger
gxk@stowers.org
816-806-1036
Stowers Institute for Medical Research

Public Release: 19-Dec-2013
Cell
A new -- and reversible -- cause of aging
Researchers have discovered a cause of aging in mammals involving a series of molecular events that disables communication between the nucleus and mitochondria. By administering a molecule naturally produced by the human body, the communication network was restored in older mice. Subsequent tissue samples showed biological hallmarks comparable to much younger animals.
NIH/National Institute on Aging, Glenn Foundation for Medical Research, and others

Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School

Public Release: 19-Dec-2013
Science
Cocaine, meth response differ between 2 substrains of 'Black 6' laboratory mouse
Researchers including Jackson Laboratory Professor Gary Churchill, Ph.D., have found a single nucleotide polymorphism difference in cocaine and methamphetamine response between two substrains of the C57BL/6 or "Black 6" inbred laboratory mouse, pointing to Cyfip2 as a regulator of cocaine response with a possible role in addiction.
NIH/National Institute on Drug Abuse

Contact: Joyce Peterson
joyce.peterson@jax.org
207-288-6058
Jackson Laboratory

Public Release: 19-Dec-2013
Science
Gene transfer gone wild reveals driving force behind mitochondrial sex
Pioneering research led by Indiana University has identified genes from a number of plant species, including the entire mitochondrial genomes from three green algae and one moss, in the mitochondrial genome of Amborella trichopoda. The South Pacific shrub is considered to be the sole survivor -- the "last man standing" -- of one of the two oldest lineages of flowering plants, while the other lineage comprises the other 300,000 species of flowering plants.
National Institutes of Health, National Science Foundation, US Department of Energy

Contact: Stephen Chaplin
stjchap@iu.edu
812-856-1896
Indiana University

Public Release: 18-Dec-2013
Stem Cells
Stem cells offer clues to reversing receding hairlines
Regenerative medicine may offer ways to banish baldness that don't involve toupees. The lab of USC scientist Krzysztof Kobielak, M.D., Ph.D., has published a trio of papers in the journals Stem Cells and The Proceedings of the National Academy of Sciences that describe some of the factors that determine when hair grows, when it stops growing and when it falls out.
National Institutes of Health, California Institute for Regenerative Medicine

Contact: Cristy Lytal
lytal@med.usc.edu
University of Southern California - Health Sciences

Public Release: 18-Dec-2013
Fatigue, a common side effect of breast cancer treatment, evaluated in novel patient study
Although the prevalence and impact of cancer-related fatigue has been well established, very little is known about its predictors, mechanisms for development, and persistence post-treatment. A new research study at the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute, in partnership with UCLA, is aimed at identifying breast cancer patients most susceptible to post-treatment fatigue by measuring biological, behavioral and social risk factors.
National Institutes of Health

Contact: Cara Martinez
cara.martinez@cshs.org
310-423-7798
Cedars-Sinai Medical Center

Public Release: 18-Dec-2013
Journal of Clinical Investigation
Role for sugar uptake in breast cancer revealed
Berkeley Lab researchers have shown that aerobic glycolysis -- glucose metabolism in the presence of oxygen -- is not the consequence of the cancerous activity of malignant cells, as has been widely believed, but is itself a cancerous event.
NIH/National Cancer Institute

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory

Public Release: 18-Dec-2013
Nature
Neanderthal genome shows early human interbreeding, inbreeding
A team that includes UC Berkeley population geneticists has produced the first high-quality genome of a Neanderthal, allowing comparison with the genomes of modern humans and Denisovans. The analysis shows a long history of interbreeding among these early humans and a fourth, previously unknown group. The Neanderthal, from Denisova cave, also shows evidence of inbreeding. About 87 genes in modern humans were found to be significantly different from related genes in Neanderthals and Denisovans.
National Institutes of Health

Contact: Robert Sanders
rlsanders@berkeley.edu
510-643-6998
University of California - Berkeley

Public Release: 18-Dec-2013
Nature Communications
Going against the flow: Halting atherosclerosis by targeting micro RNA
Researchers at Emory and Georgia Tech have developed a potential treatment for atherosclerosis that targets a master controller of the process.
NIH/National Heart, Lung and Blood Institute

Contact: Quinn Eastman
qeastma@emory.edu
404-727-7829
Emory Health Sciences

Public Release: 18-Dec-2013
JAHA: Journal of the American Heart Association
Heart disease linked with dementia in older postmenopausal women
Heart disease is linked with decreased brain function in older postmenopausal women. Women who have high blood pressure or diabetes may be at higher risk for decreasing brain function over time.
National Institutes of Health

Contact: Bridgette McNeill
bridgette.mcneill@heart.org
214-706-1135
American Heart Association

Public Release: 18-Dec-2013
JAMA Psychiatry
Markers of inflammation in the blood linked to aggressive behaviors
People with intermittent explosive disorder -- a psychiatric illness characterized by impulsivity, hostility and recurrent aggressive outbursts -- have elevated levels of two markers of systemic inflammation in their blood. The study documents a direct relationship between inflammatory markers and impulsive aggression that is not seen in people in good mental health or with other psychiatric disorders.
NIH/National Institute of Mental Health, University of Colorado, Denver

Contact: John Easton
john.easton@uchospitals.edu
773-795-5225
University of Chicago Medical Center

Public Release: 18-Dec-2013
Neuron
Brain area attacked by Alzheimer's links learning and rewards
One of the first areas of the brain to be attacked by Alzheimer's disease, the posterior cingulate cortex, or PCC, has been found to step in during a cognitive challenge to improve the brain's performance. This small study in monkeys establishes a role for the PCC in learning and its connection to the brain's reward system.
National Institutes of Health

Contact: Karl Leif Bates
karl.bates@duke.edu
919-681-8054
Duke University

Public Release: 18-Dec-2013
PLOS ONE
Stress reaction gene linked to death, heart attacks
A genetic trait known to make some people especially sensitive to stress also appears to be responsible for a 38 percent increased risk of heart attack or death in patients with heart disease, scientists at Duke Medicine report.
NIH/National, Heart, Lung, and Blood Institute

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center

Public Release: 18-Dec-2013
Science Translational Medicine
Newly identified immune receptor may activate B cells in autoimmunity
A newly identified immune protein influences each person's response to vaccines and risk for autoimmune diseases like lupus and multiple sclerosis. The protein, called a receptor and part of signaling pathways, also provides a new target for personalized therapies for patients with autoimmune diseases.
National Institutes of Health, American College of Rheumatology

Contact: Greg Williams
gdw@uab.edu
205-721-0710
University of Alabama at Birmingham

Showing releases 2951-2975 out of 3499.

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