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Department of Health and Human Services

News from the National Institutes of Health

Funded News

Key: Meeting M      Journal J      Funder F

Showing releases 2976-3000 out of 3520.

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Public Release: 2-Jan-2014
ACS Chemical Biology
Scientists uncover image of muscular dystrophy defect & design targeted drug candidates
Scientists from the Florida campus of The Scripps Research Institute have revealed an atomic-level view of a genetic defect that causes a form of muscular dystrophy, myotonic dystrophy type 2, and have used this information to design drug candidates with potential to counter those defects -- and reverse the disease.
National Institutes of Health, Muscular Dystrophy Association

Contact: Eric Sauter
Scripps Research Institute

Public Release: 2-Jan-2014
Therapeutic Advances in Cardiovascular Disease
High blood pressure potentially more dangerous for women than men
Doctors may need to treat high blood pressure in women earlier and more aggressively than they do in men, according to scientists at Wake Forest Baptist Medical Center.
NIH/National Heart, Blood, Lung Institute

Contact: Marguerite Beck
Wake Forest Baptist Medical Center

Public Release: 2-Jan-2014
Cell Stem Cell
Biologists discover solution to problem limiting development of human stem cell therapies
Biologists at UC San Diego have discovered an effective strategy that could prevent the human immune system from rejecting the grafts derived from human embryonic stem cells, a major problem now limiting the development of human stem cell therapies.
National Institutes of Health, California Institute for Regenerative Medicine

Contact: Kim McDonald
University of California - San Diego

Public Release: 2-Jan-2014
Journal of Clinical Investigation
Doxorubicin-associated mitochondrial iron accumulation promotes cardiotoxicity
In this issue of the Journal of Clinical Investigation, Hossein Ardehali and colleagues at Northwestern University determined that doxorubicin accumulates within the mitochondria of cardiomyocytes and this accumulation promotes mitochondrial ROS production and iron accumulation.
National Institutes of Health, NIH/National Cancer Institute

Contact: Corinne Williams
Journal of Clinical Investigation

Public Release: 2-Jan-2014
Journal of Clinical Investigation
Opioid tolerance and pain hypersensitivity associated with mTOR activation
In this issue of the Journal of Clinical Investigation, Yuan-Xiang Tao and colleagues from the New Jersey Medical School at Rutgers University report that the protein mTOR, which is a global regulator of translation, plays a major role in morphine tolerance.
National Institutes of Health, Rita Allen Foundation, National Natural Science Foundation of China

Contact: Corinne Williams
Journal of Clinical Investigation

Public Release: 1-Jan-2014
JAMA Psychiatry
Alcohol, tobacco, drug use far higher in severely mentally ill
Researchers at Washington University School of Medicine in St. Louis and the University of Southern California have found that rates of smoking, drinking and drug use are significantly higher among those who have psychotic disorders than in the general population. And that finding is of particular concern because individuals with severe mental illness are more likely to die at younger ages than people who don't have psychiatric disorders.
NIH/National Institute on Drug Abuse, NIH/National Institute on Alcohol Abuse and Alcoholism, NIH/National Institute of Mental Health, NIH/National Cancer Institute, American Cancer Society

Contact: Jim Dryden
Washington University School of Medicine

Public Release: 31-Dec-2013
GRU joins national research cooperative to improve reproductive health
Georgia Regents University has joined the national Cooperative Multicenter Reproductive Medicine Network designed to enable large clinical trials that improve the diagnosis and treatment of reproductive health issues such as male and female infertility.
National Institutes of Health

Contact: Toni Baker
Medical College of Georgia at Georgia Regents University

Public Release: 30-Dec-2013
ACS Nano
Imaging technology could unlock mysteries of a childhood disease
A new technique for studying the structure of the childhood RSV virus and its activity in living cells could help researchers unlock the secrets of the virus, including how it enters cells, how it replicates, and perhaps why certain lung cells escape the infection relatively unscathed.
National Institutes of Health, NIH/National Institute of General Medical Sciences

Contact: John Toon
Georgia Institute of Technology

Public Release: 30-Dec-2013
American Journal of Transplantation
Study identifies potential new strategy to improve odds of corneal transplant acceptance
For the estimated 10 percent of patients whose bodies reject a corneal transplant, the odds of a second transplant succeeding are poor. All that could change, however, based on a UT Southwestern Medical Center study that has found a way to boost the corneal transplant acceptance rate.
National Institutes of Health, Research to Prevent Blindness

Contact: Debbie Bolles
UT Southwestern Medical Center

Public Release: 30-Dec-2013
Proceedings of the National Academy of Sciences
Testosterone in male songbirds may enhance desire to sing but not song quality
Introducing testosterone in select areas of a male canary's brain can affect its ability to successfully attract and mate with a female through birdsong. These findings could shed light on how testosterone acts in the human brain to regulate speech or help explain how anabolic steroids affect human behaviors.
NIH/National Institute of Neurological Disorders and Stroke

Contact: Latarsha Gatlin
Johns Hopkins University

Public Release: 30-Dec-2013
JAMA Neurology
High good and low bad cholesterol levels are healthy for the brain, too
High levels of "good" cholesterol and low levels of "bad" cholesterol are correlated with lower levels of the amyloid plaque deposition in the brain that is a hallmark of Alzheimer's disease, in a pattern that mirrors the relationship between good and bad cholesterol in cardiovascular disease, UC Davis researchers have found.
NIH/National Institute on Aging, Canadian Institutes of Health

Contact: Phyllis Brown
University of California - Davis Health System

Public Release: 30-Dec-2013
JAMA Pediatrics
Conversations on sex lacking between doctors and teens
Doctors are missing a prime opportunity to share information about sex with their teenage patients by failing to broach the subject during checkups, according to researchers at Duke Medicine.
NIH/National Heart, Lung and Blood Institute

Contact: Rachel Harrison
Duke University Medical Center

Public Release: 30-Dec-2013
Journal of General Physiology
Nicotine exploits COPI to foster addiction
A study in the Journal of General Physiology helps explain how nicotine exploits the body's cellular machinery to promote addiction. The findings could lead to new therapies to help people quit smoking.
National Institutes of Health, California Tobacco-Related Disease Research Program

Contact: Rita Sullivan King
Rockefeller University Press

Public Release: 27-Dec-2013
Neurorehabilitation & Neural Repair
Stroke researchers report improvement in spatial neglect with prism adaptation therapy
Stroke rehabilitation researchers report improvement in spatial neglect with prism adaptation therapy. This new study supports behavioral classification of patients with spatial neglect as a valuable tool for assigning targeted, effective early rehabilitation with prism adaptation. Results of the study, "Presence of motor-intentional aiming deficit predicts functional improvement of spatial neglect with prism adaptation" DOI: 10.1177/1545968313516872 were published ahead of print in Neurorehabilitation and Neural Repair on December 27, 2013.
Kessler Foundation, National Institute on Disability and Rehabilitation Research, National Institutes of Health

Contact: Carolann Murphy
Kessler Foundation

Public Release: 26-Dec-2013
Proceedings of the National Academy of Sciences
Discovering a 'THRIL' that correlates with severity of Kawasaki disease
A newly identified RNA-protein complex controls TNF-alpha expression -- suggesting that it plays a key role in inflammatory immune responses.
National Institutes of Health

Contact: Susan Gammon
Sanford-Burnham Medical Research Institute

Public Release: 26-Dec-2013
Biochimica et Biophysica Acta-General Subjects
Antioxidant drug knocks down multiple sclerosis-like disease in mice
Researchers at Oregon Health & Science University have discovered that an antioxidant designed more than a dozen years ago to fight damage within human cells significantly helps symptoms in mice that have a multiple sclerosis-like disease.
National Institutes of Health

Contact: Todd Murphy
Oregon Health & Science University

Public Release: 26-Dec-2013
Cell Reports
UTSW study identifies potential therapeutic target for incurable, rare type of soft-tissue cancer
A deadly, rare type of soft-tissue cancer may be completely eradicated simply by inhibiting a key protein involved in its growth, UT Southwestern Medical Center researchers report.
Dermatology Foundation, NIH/National Cancer Institute, and others

Contact: Debbie Bolles
UT Southwestern Medical Center

Public Release: 26-Dec-2013
Proceedings of the National Academy of Sciences
Rock And Rho: Proteins that help cancer cells groove
Biologists at The Johns Hopkins University have discovered that low oxygen conditions, which often persist inside tumors, are sufficient to initiate a molecular chain of events that transforms breast cancer cells from being rigid and stationery to mobile and invasive. Their evidence, published online in Proceedings of the National Academy of Sciences on Dec. 9, underlines the importance of hypoxia-inducible factors in promoting breast cancer metastasis.
NIH/National Cancer Institute

Contact: Vanessa McMains
Johns Hopkins Medicine

Public Release: 26-Dec-2013
Health Expectations
What does compassion sound like?
"Good to see you. I'm sorry. It sounds like you've had a tough, tough, week." Spoken by a doctor to a cancer patient, that statement is an example of compassionate behavior observed by a University of Rochester Medical Center team in a new study published by the journal Health Expectations.
NIH/National Cancer Institute

Contact: Leslie Orr
University of Rochester Medical Center

Public Release: 26-Dec-2013
JAMA Otolaryngology - Head & Neck Surgery
Surgery beats chemotherapy for tongue cancer, U-M study finds
Patients with tongue cancer who started their treatment with a course of chemotherapy fared significantly worse than patients who received surgery first, according to a new study from researchers at the University of Michigan Comprehensive Cancer Center.
NIH/National Cancer Institute, NIH/National Institute of Dental and Craniofacial Research

Contact: Nicole Fawcett
University of Michigan Health System

Public Release: 25-Dec-2013
Rheumatoid arthritis research shows the potential of large-scale genetic studies for drug discovery
The results of the largest international study to date into the genetic basis of rheumatoid arthritis shed light on the biology of the disease and provide evidence that large-scale genetic studies can assist in the identification of new drugs for complex disorders such as rheumatoid arthritis.
National Institutes of Health

Contact: Juliette Savin

Public Release: 25-Dec-2013
New genetic risk factor for type 2 diabetes revealed
An international team of researchers in Mexico and the United States has uncovered a new genetic clue that contributes to an increased risk of developing type 2 diabetes, particularly the elevated risk among Mexican and other Latin American populations.
Carlos Slim Foundation, Consejo Nacional de Ciencia y Tecnología, National Institutes of Health, and others

Contact: Nicole Davis
Broad Institute of MIT and Harvard

Public Release: 25-Dec-2013
Epigenetics enigma resolved
Scientists have obtained the first detailed molecular structure of a member of the Tet family of enzymes. The finding is important for the field of epigenetics because Tet enzymes chemically modify DNA, changing signposts that tell the cell's machinery "this gene is shut off" into other signs that say "ready for a change."
NIH/National Institute of General Medical Sciences

Contact: Quinn Eastman
Emory Health Sciences

Public Release: 24-Dec-2013
Widely-used anti-inflammatory drug shows success in treatment of amyloidosis
A recent study led by researchers from the Amyloidosis Center at Boston University School of Medicine and Boston Medical Center demonstrates that diflunisal, a generic anti-inflammatory drug, successfully reduced neurological decline and preserved the quality of life in patients with familial transthyretin amyloidosis. Diflunisal is an inexpensive and safe medication marketed over the past 40 years for arthritis and pain.
NIH/National Institute of Neurological Disorders and Stroke, Food and Drug Administration, Young Family Amyloid Research Fund

Contact: Jenny Eriksen Leary
Boston University Medical Center

Public Release: 23-Dec-2013
JAMA Ophthalmology
Common antibiotic may combat dry eye disease
Meibomian gland dysfunction (MGD) is the leading cause of dry eye disease, which affects tens of millions of Americans. However, there is no FDA-approved treatment for MGD. Researchers from the Schepens Eye Research Institute/Massachusetts Eye and Ear and Harvard Medical School have just identified a potential therapy.
National Institutes of Health

Contact: Mary Leach
Massachusetts Eye and Ear Infirmary

Showing releases 2976-3000 out of 3520.

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