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Department of Health and Human Services

News from the National Institutes of Health

Funded News


Key: Meeting M      Journal J      Funder F

Showing releases 301-325 out of 3556.

<< < 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 > >>

Public Release: 20-Nov-2014
Genetics in Medicine
Panel-based genetic diagnostic testing for inherited eye disease proves highly accurate
Gene panel-based tests for inherited eye disorders have been previously reported, but none of these have been as thoroughly characterized with regard to their performance in a diagnostic setting as the GEDi test. Mass. Eye and Ear researchers put GEDi to the test.
National Institutes of Health, March of Dimes, Foundation Fighting Blindness

Contact: Mary Leach
Mary_Leach@meei.harvard.edu
Massachusetts Eye and Ear Infirmary

Public Release: 20-Nov-2014
Nature Communications
New computer model predicts gut metabolites to better understand gastrointestinal disease
Tufts University School of Engineering researchers and collaborators from Texas A&M University have published the first research to use computational modeling to predict and identify the metabolic products of gastrointestinal tract microorganisms. Understanding these metabolic products, or metabolites, could influence how clinicians diagnose and treat GI diseases, as well as many other metabolic and neurological diseases increasingly associated with compromised GI function.
National Science Foundation, National Institutes of Health

Contact: Katie Cinnamond Benoit
katherine.cinnamond@tufts.edu
617-627-4703
Tufts University

Public Release: 20-Nov-2014
PLOS Genetics
New study reveals why some people may be immune to HIV-1
Doctors have long been mystified as to why HIV-1 rapidly sickens some individuals, while in others the virus has difficulties gaining a foothold. Now, a study of genetic variation in HIV-1 and in the cells it infects reported by University of Minnesota researchers in this week's issue of PLOS Genetics has uncovered a chink in HIV-1's armor that may, at least in part, explain the puzzling difference -- and potentially open the door to new treatments.
NIH/National Institute of Allergy and Infectious Diseases, NIH/National Institute of General Medical Sciences

Contact: Stephanie Xenos
sxenos@umn.edu
612-624-8723
University of Minnesota

Public Release: 20-Nov-2014
Cell
Penn researchers unwind the mysteries of the cellular clock
Underlying circadian rhythms is a clock built of transcription factors that control the oscillation of genes, serving as the wheels and springs of the clock. But, how does a single clock keep time in multiple phases at once? A genome-wide survey found that circadian genes and regulatory elements called enhancers oscillate daily in phase with nearby genes -- both the enhancer and gene activity peak at the same time each day.
National Institutes of Health

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Public Release: 20-Nov-2014
Cell
Largest-ever map of the human interactome predicts new cancer genes
Scientists have created the largest-scale map to date of direct interactions between proteins encoded by the human genome and newly predicted dozens of genes to be involved in cancer.
NIH/National Human Genome Research Institute, Krembil Foundation, Canada Excellence Research Chair, Avon Foundation, Ontario Research Fund, NIH/National Heart, Lung, and Blood Institute

Contact: Lindsay Jolivet
lindsay.jolivet@cifar.ca
416-971-4876
Canadian Institute for Advanced Research

Public Release: 20-Nov-2014
PLOS Neglected Tropical Diseases
Breakthrough in managing yellow fever disease
Found in South America and sub-Saharan Africa, each year yellow fever results in 200,000 new cases and kills 30,000 people. About 900 million people are at risk of contracting the disease. Now a research team led by a biomedical scientist at UC Riverside has determined that the yellow fever virus, a hemorrhagic fever virus, replicates primarily in the liver; other organ failures that often follow in people with the disease are due to secondary effects.
NIH/National Institute of Allergy and Infectious Diseases

Contact: Iqbal Pittalwala
iqbal@ucr.edu
951-827-6050
University of California - Riverside

Public Release: 20-Nov-2014
Cell Reports
Signaling molecule crucial to stem cell reprogramming
While investigating a rare genetic disorder, researchers at the University of California, San Diego School of Medicine have discovered that a ubiquitous signaling molecule is crucial to cellular reprogramming, a finding with significant implications for stem cell-based regenerative medicine, wound repair therapies and potential cancer treatments.
California Institute for Regenerative Medicine, National Institutes of Health, UC San Diego Stem Cell Program, NIH/National Institute of Child Health and Human Development

Contact: Scott LaFee
slafee@ucsd.edu
619-543-5232
University of California - San Diego

Public Release: 20-Nov-2014
Journal of Health and Social Behavior
Job authority increases depression symptoms in women, decreases them in men
A new study finds that having job authority increases symptoms of depression among women, but decreases them among men.
NIH/National Institute on Aging

Contact: Daniel Fowler
pubinfo@asanet.org
202-527-7885
American Sociological Association

Public Release: 20-Nov-2014
Chemistry & Biology
Researchers report way to target hard-to-hit site in disease pathway
Researchers have successfully targeted an important molecular pathway that fuels a variety of cancers and related developmental syndromes called 'Rasopathies.' Reporting their results Nov. 20 in Chemistry & Biology, scientists at Cincinnati Children's Hospital Medical Center say they identified a class of lead compounds that successfully recognize a key target in the Ras signaling pathway -- opening the door to future development of therapies that could make treatments more effective with fewer side effects.
National Institutes of Health

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center

Public Release: 20-Nov-2014
PLOS Neglected Tropical Diseases
Breakthrough in managing yellow fever disease
Yellow fever is a disease that can result in symptoms ranging from fever to severe liver damage. Found in South America and sub-Saharan Africa, each year the disease results in 200,000 new cases and kills 30,000 people. About 900 million people are at risk of contracting the disease.
National Institutes of Health

Contact: Lauren Bullen
plosntds@plos.org
415-590-3548
PLOS

Public Release: 20-Nov-2014
Science
Staying ahead of the game: Pre-empting flu evolution may make for better vaccines
An international team of researchers has shown that it may be possible to improve the effectiveness of the seasonal flu vaccine by 'pre-empting' the evolution of the influenza virus.
National Institutes of Health

Contact: Craig Brierley
craig.brierley@admin.cam.ac.uk
44-012-237-66205
University of Cambridge

Public Release: 19-Nov-2014
New England Journal of Medicine
Gene therapy provides safe, long-term relief for patients with severe hemophilia B
Gene therapy developed at St. Jude Children's Research Hospital, University College London and the Royal Free Hospital has transformed life for men with a severe form of hemophilia B by providing a safe, reliable source of the blood clotting protein Factor IX that has allowed some to adopt a more active lifestyle, researchers reported. The results appear in the Nov. 20 edition of the New England Journal of Medicine.
NIH/National Heart, Lung, and Blood Institute, Assisi Foundation of Memphis, Howard Hughes Medical Institute, ALSAC, Medical Research Council, Katharine Dormandy Trust, NHS Blood and Transplant, and others

Contact: Carrie Strehlau
carrie.strehlau@stjude.org
901-595-2295
St. Jude Children's Research Hospital

Public Release: 19-Nov-2014
Journal of Biological Chemistry
Researchers identify protein mutation that alters tissue development in males before birth
Case Western Reserve researchers have identified a protein mutation that alters specific gender-related tissue in males before birth and can contribute to the development of cancer as well as other less life-threatening challenges. The findings appear in the Nov. 21 edition of the Journal of Biological Chemistry, whose editors named the article its Paper of the Week.
National Institutes of Health

Contact: Jeannette Spalding
jeannette.spalding@case.edu
216-368-3004
Case Western Reserve University

Public Release: 19-Nov-2014
Nature
Major new study reveals new similarities and differences between mice and humans
Powerful clues have been discovered about why the human immune system, metabolism, stress response, and other life functions are so different from those of the mouse. A new, comprehensive study of the mouse genome by an international team reveals striking similarities and differences with the human genome. The study may lead to better use of mouse models in medical research.
NIH/National Human Genome Research Institute

Contact: Barbara K. Kennedy
science@psu.edu
814-863-4682
Penn State

Public Release: 19-Nov-2014
New England Journal of Medicine
MSK team makes key discovery in understanding immunotherapy's successes -- and its failures
A collaborative team of leaders in the field of cancer immunology from Memorial Sloan Kettering Cancer Center has made a key discovery that advances the understanding of why some patients respond to ipilimumab, an immunotherapy drug, while others do not.
Ludwig Cancer Research, Frederick Adler Fund, National Institutes of Health, Swim Across America, Ludwig Trust, Melanoma Research Alliance, Stand Up To Cancer-Cancer Research Institute Immunotherapy Dream Team

Contact: Jeanne D'Agostino
dagostij@mskcc.org
212-639-3573
Memorial Sloan Kettering Cancer Center

Public Release: 19-Nov-2014
New England Journal of Medicine
A signature for success
A team led by Ludwig and Memorial Sloan Kettering researchers has published a landmark study on the genetic basis of response to a powerful cancer therapy known as immune checkpoint blockade. Their paper, in the current issue of the New England Journal of Medicine, describes the precise genetic signatures in melanoma tumors that determine whether a patient will respond to one such therapy.
Ludwig Cancer Research, Frederick Adler Fund, US National Institutes of Health, Swim Across America, Ludwig Trust, Melanoma Research Alliance

Contact: Rachel Steinhardt
rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research

Public Release: 19-Nov-2014
Nature Materials
Spiraling light, nanoparticles and insights into life's structure
As hands come in left and right versions that are mirror images of each other, so do the amino acids and sugars within us. But unlike hands, only the left-oriented amino acids and the right-oriented sugars ever make into life as we know it.
Center for Solar and Thermal Energy Conversion, Energy Frontier Research Center funded by the US Department of Energy, National Science Foundation, National Institutes of Health

Contact: Nicole Casal Moore
ncmoore@umich.edu
734-647-7087
University of Michigan

Public Release: 19-Nov-2014
International Journal of Environmental Research and Public Health
UTMB scientist finds marker that predicts cholesterol level changes as people grow older
It's known that cholesterol levels typically rise as people age and that high cholesterol levels are associated with increased risk of cardiovascular disease. What's less known is that cholesterol levels begin to decline the more a person ages. Recently, researchers from the University of Texas Medical Branch at Galveston and the University of Kentucky found that differences in one gene can influence a person's cholesterol levels from midlife to late life.
National Institutes of Health

Contact: Donna Ramirez
donna.ramirez@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston

Public Release: 19-Nov-2014
Nature
Humans and mice: So similar but yet so different
An international consortium including researchers from the CRG has presented an exhaustive description of the mouse's functional genome elements and their comparison with the human genome. The work at the CRG was carried out in close collaboration with the group directed by Dr. Thomas R. Gingeras, at CSHL. Comparing humans and mice enables us to better understand mammalian biology and evolution, as well as contributing new information on the use of mice as animal models for looking at human disease.
National Institutes of Health, NIH/National Human Genome Research Institute

Contact: Laia Cendrós
laia.cendros@crg.eu
34-933-160-237-346-07611
Center for Genomic Regulation

Public Release: 19-Nov-2014
Nature
Variation in expression of thousands of genes kept under tight constraint in mice, humans
An international team has identified 6,600 genes whose level of expression varies within a comparatively restricted range in humans and mice. The 6,600 genes represent about one-third of the total set of genes typically active in cells across tissues in both species, irrespective of cell type. The study provides new information that will continue to assist in making the mouse an excellent model organism in which to study human diseases and biology.
NIH/National Human Genome Research Institute, Spanish Plan Nacional, European Research Council, LaCaixa, European Union

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory

Public Release: 19-Nov-2014
Infant Mental Health Journal
Fathers' engagement with baby depends on mother
Fathers' involvement with their newborns depends on mothers' preparation for parenthood, even for fathers who show the most parenting skills, a new study suggests.
National Science Foundation, NIH/National Institute of Child Health and Human Development

Contact: Sarah Schoppe-Sullivan
Schoppe-Sullivan.1@osu.edu
614-688-3437
Ohio State University

Public Release: 19-Nov-2014
Cancer
Study finds wide variation in quality, content of clinical cancer guidelines
What's the best way to treat rectal cancer? Consult any of five top clinical guidelines for rectal cancer and you will get a different answer, according to a new study by researchers at the University of Michigan Comprehensive Cancer Center.
Agency for Healthcare Research and Quality, NIH/National Cancer Institute

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 19-Nov-2014
Drug and Alcohol Dependence
Residential treatment may be first-line option for opioid-dependent young adults
A study from the Massachusetts General Hospital Center for Addiction Services found that a month-long, 12-step-based residential program with strong linkage to community-based follow-up care, enabled almost 30 percent of opioid-dependent young adults to remain abstinent a year later. Another recent study found that 83 percent of young adults entering an office-based opioid treatment program had dropped out a year later.
NIH/National Institute of Alcohol Abuse and Alcoholism, Hazelden Betty Ford Foundation

Contact: Noah Brown
nbrown9@partners.org
617-643-3907
Massachusetts General Hospital

Public Release: 19-Nov-2014
Nature Communications
Power behind 'master' gene for cancer discovered
It's hard to believe, but there are similarities between bean sprouts and human cancer. The same mechanisms that result in bigger bean sprouts also cause cancer metastasis and tumor development.
National Institutes of Health, Fidelity Foundation, Susan G. Komen Breast Cancer Foundation

Contact: Ron Gilmore
rgilmore1@mdanderson.org
713-745-1898
University of Texas M. D. Anderson Cancer Center

Public Release: 19-Nov-2014
American Heart Association's Scientific Sessions 2014
High-quality hospitals deliver lowest-cost care for congenital heart surgery patients
US children's hospitals delivering the highest-quality care for children undergoing heart surgery, also appear to provide care most efficiently at a low cost, according to research led by the University of Michigan and presented Tuesday at the American Heart Association Scientific Sessions in Chicago.
NIH/National Heart, Lung, and Blood Institute

Contact: Mary Masson
mfmasson@umich.edu
734-764-2220
University of Michigan Health System

Showing releases 301-325 out of 3556.

<< < 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 > >>

     
   

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